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glycineamide ribonucleotide
structure
Also Known As:
5'-phosphoribosylglycineamide; glycineamideribotide; 2-amino-(N-D-ribofuranosyl)acetamide 5'-phosphate
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleotides: 15763
Ribonucleotides: 307
glycineamide ribonucleotide: 3
Experts
1.
Assaraf, Yehuda G
: 1 article (03/2007)
Related Diseases
1.
T-Cell Leukemia (Leukemia, T Cell)
09/15/1992 - "
Metabolic effects and mode of cytotoxicity of 5-deazaacyclotetrahydrofolate (5-DACTHF, BW543U76), a glycineamide ribonucleotide transformylase inhibitor, were studied in MOLT-4 cells, a human T-cell leukemia line.
"
09/15/1992 - "
Metabolic effects and kill of human T-cell leukemia by 5-deazaacyclotetrahydrofolate, a specific inhibitor of glycineamide ribonucleotide transformylase.
"
2.
Colorectal Neoplasms (Colorectal Cancer)
03/01/2007 - "
Recently, the novel antifolates raltitrexed and pemetrexed that target thymidylate synthase (TS) and glycineamide ribonucleotide transformylase (GARTF) were introduced for the treatment of colorectal cancer and malignant pleural mesothelioma.
"
3.
Carcinoma (Carcinomatosis)
03/15/1994 - "
We have investigated the potential of glycineamide ribonucleotide transformylase (GAR TFase) inhibitors to produce regressions in multiple preclinical models of colon carcinoma.
"
4.
Malignant Mesothelioma
03/01/2007 - "
Recently, the novel antifolates raltitrexed and pemetrexed that target thymidylate synthase (TS) and glycineamide ribonucleotide transformylase (GARTF) were introduced for the treatment of colorectal cancer and malignant pleural mesothelioma.
"
Related Drugs and Biologics
1.
Hydroxymethyl and Formyl Transferases
2.
Phosphoribosylglycinamide Formyltransferase
3.
Thymidylate Synthase
4.
Folic Acid Antagonists
5.
Pemetrexed (MTA)
6.
raltitrexed (D 1694)