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LON 954

RN given refers to mono-HCl; structure

Also Known As:

N-carbamoyl-2-(2,6-dichlorophenyl)acetamidine hydrochloride; N-(aminocarbonyl)-2,6-dichlorobenzeneethanimidamide, monohydrochloride

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - LON 954: 2

Related Diseases

1.	Tremor (Tremors) 02/01/1980 - "Tremor produced in laboratory mice by the benzylimidoylurea derivative LON 954 was potentiated in a dose-dependent manner by a variety of typical and atypical neuroleptics. " 02/01/1980 - "Potentiation of LON 954 tremor by typical and atypical neuroleptics--an indication of striatal dopamine antagonism." 04/29/1977 - "N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride (LON 954) causes a reproducible rest tremor in mice, of rapid onset and short duration with no associated rigidity or akinesia and in the absence of any marked changes in body temperature or accompanying peripheral parasympathomimetic effects. "
2.	Parkinson Disease (Parkinson's Disease) 04/29/1977 - "LON 954 appears to be more specific than oxotremorine for the detection of drugs having therapeutic potential in the treatment of Parkinson's disease, particularly those exerting their effect through dopaminergic systems. "

Related Drugs and Biologics

1.	Antipsychotic Agents (Antipsychotics)
2.	Parasympathomimetics
3.	Oxotremorine
4.	Dopamine (Intropin)
5.	acetamidine