6-chloro-2-(1-piperazinyl)pyrazine (CPP)

01/01/2021 - "Magnetic Resonance Imaging (MRI) is the best approach to investigate the hypothalamic-pituitary region in children with central precocious puberty (CPP). "
11/27/2023 - "In recent years, central precocious puberty (CPP) in children is becoming more common, which seriously affects their physical and psychological health and requires finding a safe and effective treatment method. "
01/01/2022 - "The purpose of this study was to compare the efficacy of a LA 11.25 mg 3-month depot with that of a 3.75 mg 1-month depot in suppressing pubertal development for the treatment of central precocious puberty (CPP). "
01/01/2022 - "However, it is the diagnostic gold standard for central precocious puberty (CPP), which in girls is defined as the onset of secondary sexual characteristics before the age of 8 years accompanied by breast buds, accelerated growth, and advanced bone age. "
12/01/2023 - "DLK1 and MKRN3 that previously described as cause of the central precocious puberty (CPP) in human were differentially expressed in this study. "

01/01/2019 - "Clinician and patient factors impact on the management of chronic pelvic pain (CPP) with medical, surgical or combined approaches possible, although none have proven superior. "
01/01/2022 - "Management of chronic pelvic pain (CPP) remains a huge challenge for care providers and a major burden for healthcare systems. "
03/01/2020 - "Forty-four percent and 38% of patients with chronic pelvic pain (CPP) presented an improvement in postoperative PCS and Mental Component Summary scores (ES>0.8) versus 23% and 24% of patients without CPP, respectively (p <.001). "
12/01/2019 - "Objective: To summarize the available scientific evidence on physiotherapy interventions in the management of chronic pelvic pain (CPP). "
08/01/2017 - "To provide an update on nonsurgical and nonpharmacologic strategies for the management of chronic pelvic pain (CPP). "

01/01/2006 - "In this open, randomized study, distension of painful pelvic structures in women with CPP resulted in significant relief of pain and improvement in quality of life measures."
01/01/2012 - "We determined in our study that PTNS improved the quality of life of women with CPP by decreasing the intensity of pain and contributed to a more comfortable performance of their daily activities. "
02/01/2015 - "Evaluation of anthropometric parameters and pain measurements can be applied in clinical practice, making a contribution to the diagnosis and influencing the choice of a more effective treatment for women with CPP."
01/01/2022 - "Treatment with TUS and IA were effective in reducing clinical pain and improving quality of life in women with AMPS secondary to CPP. "
04/01/2005 - "Intravaginal electrical stimulation is effective in the alleviation of pain in women with CPP."

12/14/2018 - "In spite of significant progress in design and application of CPP, more investigations are required to further improve their delivery to tumors, with reduced side-effect and enhanced therapeutic efficacy. "
10/01/2021 - "CPP have been effective for delivery of various chemotherapeutic agents used to combat cancer. "
09/06/2017 - "The finding of a lower excess mortality among CPP referred compared to non-CPP referred patients indicates that CPPs may have improved the cancer prognosis independently."
07/29/2015 - "At tumor extracellular pH 6.8, the hydrolysis of DMA led to charge reversal, activating the pristine function of CPP for improved cellular uptake by tumor cells. "
05/01/2023 - "Furthermore, recent studies employing CPP-based PDCs for cancer and ocular disease management have been discussed in detail highlighting their significance over conventional DDS. "

02/01/2011 - "CPP caused by endometriosis or other gynecological conditions leads to a significant reduction of quality of life and sexual satisfaction."
12/01/2023 - "Based on the preliminary findings of our study, SNM might be a promising treatment of CPP in endometriosis patients."
01/01/2023 - "This clinical phase II, placebo-controlled, randomized, parallel-design study included 36 patients with endometriosis and CPP. "
01/01/2022 - "This model creates a foundation for mechanistical studies into the diffuse CPP associated with endometriosis and the development of targeted therapeutic interventions to improve the quality of life of women with endometriosis."
01/01/2022 - "The present study revealed that CPP was the factor associated with a worse QoL and work performance in women with endometrioma based on a disease-specific, EHP-30 questionnaire."