streptococcal M protein

type-specific protein on surface of group A Streptococci antigens; IgGFc-& albumin-binding streptococcal surface protein

Also Known As:

M protein type 19, Streptococcus pyogenes; M protein, serotype 49, Streptococcus pyogenes; M protein, serotype 5, Streptococcus pyogenes; M protein, serotype 6, Streptococcus pyogenes; M protein, streptococcal; M1 protein, Streptococcus; M18 protein, Streptococcus; M3 protein, Streptococcus pyogenes; M6 protein, Streptococcal gordonii; M6 protein, Streptococcus pyogenes; Smp5 protein, Streptococcus pyogenes; emm1 protein, Streptococcus; emm1 protein, Streptococcus pyogenes; emm18 protein, Streptococcus pyogenes; emm19 protein, Streptococcus pyogenes; emm3 protein, Streptococcus pyogenes; emm49 protein, Streptococcus pyogenes; emm5 protein, Streptococcus pyogenes; emm6 protein, Streptococcus pyogenes; strep M protein; strep M protein (type 15); strep M protein (type 19); strep M protein (type 3); strep M protein (type 49); strep M protein (type 5); streptococcal M-associated protein; streptococcal PepM49 protein; streptococcal class I M protein; type 6 M protein, streptococcal

Networked: 48 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cunningham, Madeleine W: 4 articles (12/2016 - 01/2002)
2.	Dale, James B: 2 articles (01/2020 - 02/2006)
3.	Govan, Brenda L: 2 articles (01/2020 - 12/2016)
4.	Ketheesan, Natkunam: 2 articles (01/2020 - 12/2016)
5.	Rush, Catherine M: 2 articles (01/2020 - 12/2016)
6.	Sikder, Suchandan: 2 articles (01/2020 - 12/2016)
7.	Guilherme, Luiza: 2 articles (02/2007 - 02/2006)
8.	Kalil, Jorge: 2 articles (02/2007 - 02/2006)
9.	Cunningham, M W: 2 articles (06/2001 - 12/2000)
10.	Fischetti, V A: 2 articles (06/2001 - 12/2000)

Related Diseases

1.	Superinfection 01/01/2020 - "To test this idea, we assessed the efficacy of passive immunotherapy using antisera against either the streptococcal M protein or streptolysin O (SLO) in a murine model of IAV-GAS superinfection. "
2.	Rheumatic Fever (Acute Articular Rheumatism) 06/01/2001 - "In this study, we investigated the hypothesis that streptococcal M protein could produce inflammatory valvular heart lesions similar to those seen in rheumatic fever (RF). " 02/15/2006 - "Temporal changes in streptococcal M protein types and the near-disappearance of acute rheumatic fever in the United States." 01/01/1989 - "Evidence for two distinct classes of streptococcal M protein and their relationship to rheumatic fever." 02/01/1996 - "To analyze the immune response to the C region of group A streptococcal M protein in patients with rheumatic fever (RF), we cloned the structural gene for the C region of type 12 M protein and produced recombinant C region of M protein. " 02/01/1996 - "Persistent elevation of immunoglobulin G titer against the C region of recombinant group A streptococcal M protein in patients with rheumatic fever."
3.	Rheumatic Heart Disease (Rheumatic Heart Diseases) 06/01/2011 - "The purpose of this study was to determine the role of streptococcal M protein in naturally-occurring CD4(+)CD25(+) regulatory T cells (nTregs) function and development in rheumatic heart disease in Iraqi patients. " 12/01/2016 - "Repeat exposure to group A streptococcal M protein exacerbates cardiac damage in a rat model of rheumatic heart disease." 06/01/2011 - "Functional and Developmental Analysis of CD4(+)CD25(+) Regulatory T Cells under the Influence of Streptococcal M Protein in Rheumatic Heart Disease." 02/01/2004 - "In rheumatic heart disease, streptococcal M protein specific T cells migrate to valves. " 10/15/2005 - "Mimicry between streptococcal M protein and cardiac myosin is important in the pathogenesis of rheumatic heart disease. "
4.	Myocarditis (Carditis) 02/01/1983 - "Studies on the pathogenesis of rheumatic carditis--cytotoxicity of serum and lymphocytes sensitized to streptococcal M protein fraction on cultured myocardial cells." 06/01/2001 - "Fifty percent (3 of 6) of Lewis rats immunized with recombinant type 6 streptococcal M protein (rM6) developed valvulitis as well as focal lesions of myocarditis. " 01/01/2022 - "In rheumatic carditis, the IgG2 subclass preferentially and strongly deposited in valve tissues (n = 4) despite elevated concentrations of IgG1 and IgG3 in RHD sera as detected by ELISA to group A streptococcal M protein. " 02/01/2004 - "By investigating streptococcal M protein and cardiac myosin in the Lewis rat model of myocarditis and valvulitis, T cell mimicry is supported as a potential mechanism in disease. " 01/01/2020 - "These observations support the contention that initial interactions between streptococcal M-protein specific Abs and/or T-cells with the heart endothelium lead to endothelial cell activation followed by transmigration of M-protein specific T-cells into heart tissue leading to an inflammatory process that leads to carditis in rheumatic fever and rheumatic heart disease."
5.	Heart Valve Diseases (Valvular Heart Disease) 06/01/2001 - "The study demonstrates that the Lewis rat is a model of valvular heart disease and that streptococcal M protein can induce an autoimmune cell-mediated immune attack on the heart valve in an animal model. " 06/01/2001 - "Induction of autoimmune valvular heart disease by recombinant streptococcal m protein." 10/01/2007 - "Immune responses against cardiac myosin lead to valvular heart disease and infiltration of the heart by Streptococcal M protein reactive T lymphocytes. " 01/01/2002 - "These data show direct evidence that immune responses against cardiac myosin lead to valvular heart disease and the infiltration of the heart by streptococcal M protein reactive T lymphocytes."

Related Drugs and Biologics

1.	Immune Sera (Antisera)
2.	streptolysin O
3.	Cardiac Myosins
4.	Antibodies
5.	Antigens
6.	Proteins (Proteins, Gene)
7.	Epitopes
8.	Peptides (Polypeptides)
9.	Keratins (Keratin)
10.	Immunoglobulin G (IgG)