9-ethylguanine

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Furukawa, Ayako: 1 article (11/2015)
2.	Higuchi, Yoshihiro: 1 article (11/2015)
3.	Hoshiyama, Miyuu: 1 article (11/2015)
4.	Komeda, Seiji: 1 article (11/2015)
5.	Sato, Takaji: 1 article (11/2015)
6.	Uemura, Masako: 1 article (11/2015)
7.	Clarkson, Guy J: 1 article (06/2015)
8.	Habtemariam, Abraha: 1 article (06/2015)
9.	Millett, Adam J: 1 article (06/2015)
10.	Romero-Canelón, Isolda: 1 article (06/2015)

1.	Leukemia 11/01/2015 - "We examined the cytotoxicity and cellular uptake in L1210 murine leukemia cells, as well as the coordinative reaction with the guanine derivative 9-ethylguanine (9EtG), of a series of μ-hydroxo-μ-tetrazolato dinuclear platinum(II) complexes (tetrazolato-bridged complexes), [{cis-Pt(NH3)2}2(μ-OH)(μ-tetrazolato-N1,N2)](2+) (5-H-X) and [{cis-Pt(NH3)2}2(μ-OH)(μ-5-R-tetrazolato-N2,N3)](n+), where R = H (5-H-Y), CH3 (1), C6H5 (2), CH2COOCH2CH3 (3), or CH2COO(-) (4), and n = 2 (5-H-Y, 1-3) or 1 (4). "
2.	Colonic Neoplasms (Colon Cancer) 06/08/2015 - "The complexes show preferential binding to 9-ethylguanine over 9-methyladenine and are active catalysts for the oxidation of NADH to NAD+. Antiproliferative activity experiments in A2780 ovarian, MCF-7 breast, A549 lung, and HCT116 colon cancer cell lines showed IC50 values ranging from 1 to 89 μM, with the most potent complex, [(η5-Cp)Ir(2-(2'-methylphenyl)pyridine)Cl] (13) (A2780 IC50 = 1.18 μM), being 10× more active than the parent, [(η5-Cp)Ir(2-phenylpyridine)Cl], and 2× more active than [(η5-CpxPh)Ir(2-phenylpyridine)Cl]. "