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1,4-bis(2,3-epoxypropoxy)butane

Also Known As:

1,4-butanediol diglycidyl ether; 1,4-butanedioldiglycidyl ether; BDDE ether cpd; BUDGIE reagent; 2,2'-(1,4-butanediylbis(oxymethylene)bisoxirane)

Networked: 7 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Alcohols: 595
  - Glycols: 38
    - Butylene Glycols: 2
      - 1,4-bis(2,3-epoxypropoxy)butane: 7

Experts

1.	Jou, I-Ming: 2 articles (10/2019 - 05/2016)
2.	Bae, Ji-Hoon: 1 article (11/2021)
3.	Bae, Ki-Cheor: 1 article (11/2021)
4.	Chang, Chong Bum: 1 article (11/2021)
5.	Ha, Chul-Won: 1 article (11/2021)
6.	In, Yong: 1 article (11/2021)
7.	Kim, Chang-Wan: 1 article (11/2021)
8.	Kim, Dong-Hwi: 1 article (11/2021)
9.	Kim, Jong-Min: 1 article (11/2021)
10.	Kim, Young-Mo: 1 article (11/2021)

Related Diseases

1.	Fibrosis (Cirrhosis) 10/10/2019 - "The aim of the present study was to examine the inhibitory effect of 1,4-butanediol diglycidyl ether-crosslinked hyaluronan (cHA) on spinal epidural fibrosis in a swine model. " 05/01/2016 - "The aim of this study was to examine the inhibitory effect of a novel material 1,4-butanediol diglycidyl ether-cross-linked hyaluronan (cHA) on fibrosis in primary tenocytes. " 05/01/2016 - "1,4-Butanediol diglycidyl ether-cross-linked hyaluronan inhibits fibrosis in rat primary tenocytes by down-regulating autophagy modulation."
2.	Knee Osteoarthritis 11/01/2021 - "This double-blind, randomized, Phase III clinical trial was conducted to assess the efficacy and safety of the novel divinyl sulfone cross-linked hyaluronate (YYD302) compared with the 1,4-butanediol diglycidyl ether cross-linked hyaluronate (Synovian) in patients with knee osteoarthritis. " 03/09/2021 - "In this pilot study, we aimed to compare polynucleotide sodium (Conjuran®) with sodium hyaluronate (Hyruan Plus®) and 1,4-butanediol diglycidyl ether-crosslinked sodium hyaluronate (Synovian®) in terms of analgesic efficacy after intraarticular injection in patients with knee osteoarthritis. "
3.	Hypersensitivity (Allergy) 02/01/1987 - "Contact allergy to an epoxy reactive diluent: 1,4-butanediol diglycidyl ether." 06/01/2015 - "The largest numbers of allergic reactions were to phenyl glycidyl ether (PGE; n = 41), 1,4-butanediol diglycidyl ether (BDDGE; n = 34), and p-tert-butylphenyl glycidyl ether (PTBPGE; n = 19). " 02/01/1987 - "3 female workers in a brush factory developed contact allergy from a 2-component epoxy glue containing epoxy resin (37% w/w), reactive diluents: i.e., 1,4-butanediol diglycidyl ether (BDDGE) 3%, glycidyl ethers of aliphatic alcohols (Epoxide 8) 0.03% and phenyl glycidyl ether (PGE) 0.01%; and inert fillers. "
4.	Wounds and Injuries (Trauma) 08/01/2015 - "Comparative histologic and immunologic evaluation of 1,4-butanediol diglycidyl ether crosslinked versus noncrosslinked acellular swim bladder matrix for healing of full-thickness skin wounds in rabbits."

Related Drugs and Biologics

1.	Hyaluronic Acid (Hyaluronan)
2.	Prostaglandins E
3.	phenylglycidyl ether
4.	Sodium
5.	Polynucleotides
6.	Ether (Diethyl Ether)
7.	Epoxy Resins
8.	Analgesics (Analgesic Drugs)
9.	Alcohols
10.	Epoxide 8

Related Therapies and Procedures

1.	Intra-Articular Injections