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U 23469
structure
Also Known As:
U 23,469; U-23,469; U-23469; cis-(3-(p-(1,2,3,4-Tetrahydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy))-1,2-propanediol
Networked:
1
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Naphthalenes: 18
Tetrahydronaphthalenes: 1
U 23469: 1
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Naphthalenes: 18
Tetrahydronaphthalenes: 1
U 23469: 1
Related Diseases
1.
Neoplasms (Cancer)
05/01/1977 - "
Treatment with U 23,469 for increasing time periods (3, 6, or 12 weeks) beginning 2 weeks after DMBA results in a progressive delay in onset of tumor appearance.
"
05/01/1977 - "
The time course of tumor regression (3 months after DMBA) by U 23,469 or ovariectomy is similar, with 50% regression in ca. 2 weeks, and both elicit regression of almost all tumors (greater than 90%).
"
05/01/1977 - "
During U 23,469 treatment, cytosol ER content is very low in regressing tumor and uterus and over 90% of ER is in the nucleus; cytosol progesterone receptor is slightly depressed in the uterus but is at the untreated level in mammary tumor.
"
05/01/1977 - "
Antagonism of development and growth of 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors by the antiestrogen U 23,469 and effects on estrogen and progesterone receptors.
"
05/01/1977 - "
This study analyzed the effectiveness of a nonsteroidal antiestrogen, cis-(3-[p-(1,2,3,4-tetrahydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy]-1,2-propanediol (U 23,469) previously shown to be potent in antagonizing estrogen-induced uterine growth, in preventing the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumors and in eliciting the regression of established tumors; the study also attempts to elucidate the mechanisms of the tumor antagonism of U 23,469.
"
Related Drugs and Biologics
1.
Estrogen Receptor Modulators (Antiestrogen)
2.
Propylene Glycol (1,2 Propanediol)
3.
Estrogens (Estrogen)
4.
anthracene
5.
Progesterone Receptors (Progesterone Receptor)
Related Therapies and Procedures
1.
Ovariectomy (Oophorectomy)