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2,3,7,8-tetrachlorodibenzofuran

toxic product which was generated in Italy due to an explosion in a plant manufacturing 2,4,5-trichlorophenol
Also Known As:
2,3,7,8-TCDF
Networked: 14 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Celius, Trine: 1 article (07/2011)
2. Matthews, Jason: 1 article (07/2011)
3. Powis, Melanie: 1 article (07/2011)
4. Rowlands, Craig: 1 article (03/2008)
5. Safe, Stephen: 1 article (03/2008)
6. Zhang, Shu: 1 article (03/2008)

Related Diseases

1. Hepatocellular Carcinoma (Hepatoma)
05/15/1996 - "In this study, the ability of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,7,8-tetrachlorodibenzofuran (TCDF), and selected chlorobiphenyl congeners to cause uroporphyria was examined in a fish hepatoma cell line (PLHC-1) that expresses aryl hydrocarbon (Ah) receptors and an inducible cytochrome P4501A (CYP1A). "
03/01/2008 - "TCDD, 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PeCDD), 2,3,7,8-tetrachlorodibenzofuran (TCDF), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), and 3,3',4,4',5-pentachlorobiphenyl (PCB126) induced CYP1A1-dependent activities in HEK293 human embryonic kidney, Panc1 pancreatic cancer, and Hepa1c1c7 mouse hepatoma cell lines. "
11/01/1996 - "2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), 2,3,7,8-tetrachlorodibenzofuran (TCDF), and benz[a]anthracene (BA) highly induce cytochrome P4501A1, determined by aryl hydrocarbon hydroxylase (AHH) activity, in human hepatoma HepG2 cells within 24 h. "
02/01/1991 - "We have now investigated the presence of both the 4 S PAH-binding protein and the 8 S Ah receptor in rat hepatoma H4-II-E cells as well as the induction of P450IA1 upon their exposure to PAH's such as benzo[a]pyrene (BP) and 3-methylcholanthrene (3MC), and halogenated dioxins such as 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) and 2,3,7,8-tetrachlorodibenzofuran (TCDBF). "
08/01/1989 - "Treatment of rat hepatoma H-4-IIE cells in culture with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,7,8-tetrachlorodibenzofuran (TCDF), 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PeCDD), 1,2,3,7,8-pentachlorodibenzofuran (PeCDF), 1,2,7,8-TCDF, and 2,3,7-trichlorodibenzo-p-dioxin (TrCDD) resulted in the structure-dependent induction of aryl hydrocarbon hydroxylase and ethoxyresorufin O-deethylase activities. "
2. Breast Neoplasms (Breast Cancer)
3. B-Cell Lymphoma (Lymphoma, B Cell)
4. Osteosarcoma (Osteogenic Sarcoma)
5. Pancreatic Neoplasms (Pancreatic Cancer)

Related Drugs and Biologics

1. Polychlorinated Dibenzodioxins (TCDD)
2. Hydrocarbons
3. Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)
4. Cytochromes
5. Mixed Function Oxygenases (Monooxygenases)
6. Cytochrome P-450 CYP1A1 (CYP1A1)
7. 1,2,3,7,8-pentachlorodibenzo-p-dioxin
8. Methylcholanthrene
9. Insulin (Novolin)
10. Dioxins