precocene II

has antibacterial, antifungal, insecticidal, and antioxidant activities; from plants of genus Ageratum; an antiallotropin compound capable of inhibiting juvenile hormone biosynthesis

Also Known As:

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Adnyana, I Ketut: 1 article (04/2022)
2.	Anggadiredja, Kusnandar: 1 article (04/2022)
3.	Sukmawan, Yedy Purwandi: 1 article (04/2022)
4.	Adebayo, Abiodun Humphrey: 1 article (09/2011)
5.	Akindahunsi, Afolabi Akintunde: 1 article (09/2011)
6.	Han, Hong-Jin: 1 article (09/2011)
7.	He, Wen-Jun: 1 article (09/2011)
8.	Jig, Chang-Jiu: 1 article (09/2011)
9.	Tana, Ning-Hua: 1 article (09/2011)
10.	Xu, Jun-Ju: 1 article (09/2011)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 01/01/2023 - "The results of the study demonstrated that caryophyllene and longifolene, but not precocene II, exerted anti-neuropathic pain activity. " 01/01/2023 - "The objective of the study was to determine the anti-neuropathic pain activity of precocene II, longifolene, and caryophyllene as single agents and in combination with pregabalin. "
2.	Necrosis 04/01/1985 - "The proallatocidin precocene II (6,7-dimethoxy-2,2-dimethyl-2H-benzo-[b]pyran) has previously been shown to induce centrolobular liver necrosis. " 01/01/1989 - "Precocene II (6,7-dimethoxy-2,2-dimethyl-2H-benzo[b]pyran), an insect growth regulator that is structurally related to several naturally occurring carcinogenic and non-carcinogenic alkenylbenzenes, is genotoxic and produces hepatic centrolobular necrosis in rats. " 08/01/1987 - "These results indicate that the level of activity of various forms of cytochrome P-450 significantly influences the severity of hepatic necrosis induced by precocene II. Furthermore, these results suggest that inducible non-P-450 factors, such as glutathione S-transferases, may be important in modulating precocene II-induced hepatotoxicity."
3.	Chromosome Breakage 05/01/1989 - "The results suggest that the main sources of genotoxic activity of precocene II are due to chromosome-breakage phenomena resulting from mitotic recombination. "
4.	Neoplasms (Cancer) 09/01/2011 - "7,3',5'-Tri-O-methyltricetin (7), precocene II (9), 3,5,7,4'-tetrahydroxyflavone (13) and 5,6,7,3',4',5'-hexamethoxyflavone (14) exhibited inhibitory activity on the P-388 cancer cell line with IC50 values of 12.8, 24.8, 3.5 and 7.8 microM respectively, while compound 9 exhibited inhibitory activity on the HT-29 cancer cell line with an IC50 value of 61 microM; the others showed no significant cytotoxic activity on the cell lines tested."
5.	Atrophy 10/01/1984 - "Juvenile hormone analogue applied topically (60 micrograms/insect) together with Precocene II treatment avoided atrophy of the prothoracic glands and induced a higher number of epidermal mitosis accelerating the time of subsequent ecdysis. "

Related Drugs and Biologics

1.	Pregabalin (Lyrica)
2.	longifolene
3.	caryophyllene
4.	Pyrans
5.	Juvenile Hormones
6.	Transferases
7.	Glutathione (Reduced Glutathione)
8.	Cytochrome P-450 Enzyme System (Cytochrome P450)