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N-nitrosodiethanolamine

Also Known As:

diethanolnitrosamine

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitroso Compounds: 446
  - Nitrosamines: 1539
    - Diethylnitrosamine: 2124
      - N-nitrosodiethanolamine: 8

Experts

1.	Bartels, M J: 1 article (04/2000)
2.	Brzak, K A: 1 article (04/2000)
3.	Mar, M: 1 article (04/2000)
4.	Markham, D A: 1 article (04/2000)
5.	Stott, W T: 1 article (04/2000)
6.	Thornton, C M: 1 article (04/2000)
7.	Zeisel, S H: 1 article (04/2000)

Related Diseases

1.	Neoplasms (Cancer) 06/01/1983 - "The results of this study demonstrate that N-nitrosodiethanolamine is organospecific for the Syrian golden hamster nasal cavity and trachea and that it induces tumors in these sites at doses lower than previously reported." 10/01/1981 - "Weekly subcutaneous injections of N-nitrosodiethanolamine (NDELA) at doses of 1000, 500 and 250 mg/kg body wt for life induced tumors in Syrian hamsters which primarily affected the upper respiratory tract. " 09/01/1986 - "The metabolism of N-nitrosodiethanolamine (NDELA) was studied to assess whether the formation of the beta-oxidated metabolites N-(2-hydroxyethyl)-N-(formylmethyl)nitrosamine (EFMN) and N-(2-hydroxyethyl)-N-(carboxymethyl)nitrosamine (ECMN) is involved in the mechanism of tumor induction in various animal species with different susceptibility to NDELA carcinogenicity. " 01/01/1984 - "Methapyrilene hydrochloride (MPHC), N-nitrosomethylaniline (NMA), N-nitrosomethyl-3-carboxypropylamine (NMCP) and N-nitrosodiethanolamine (NDELA) are reputed to be nonmutagenic carcinogens because they are genetically inactive in Salmonella mutagenesis tests but produce cancer in rats. "
2.	Carcinogenesis 01/01/1991 - "Initiating activity of N-nitrosodiethanolamine (NDELA) for rat liver carcinogenesis was investigated using an 8-weeks bioassay system. " 12/01/1984 - "The results suggest that N-nitroso-2-hydroxymorpholine, which is formed by metabolic beta-oxidation of N-nitrosodiethanolamine, could be involved in carcinogenesis by N-nitrosodiethanolamine."
3.	Chromosome Aberrations (Chromosome Abnormalities) 01/01/1988 - "The mutagenicity of N-nitrosodiethanolamine (NDELA) and NDELA monoacetate was tested in vitro on lymphocytes of two healthy probands by determining the frequencies of chromosome aberrations, micronuclei and sister chromatid exchanges (SCE). "
4.	Choline Deficiency 04/03/2000 - "In an attempt to define the tumorigenic mechanism of DEA, N-nitrosodiethanolamine (NDELA) formation in vivo and development of choline deficiency were examined in mice. "

Related Drugs and Biologics

1.	Methapyrilene
2.	Carcinogens
3.	N-methylchlorphentermine
4.	N-nitroso-2-hydroxymorpholine
5.	N- (2- hydroxyethyl)- N- (formylmethyl)nitrosamine (EFMN)
6.	N-methyl-N-nitrosoaniline

Related Therapies and Procedures

1.	Subcutaneous Injections