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juncusol

cytotoxic dihydro phenanthrene from Estuarian marsh plant Juncus roemerianus; structure

Also Known As:

juncunol; 2,7-Phenanthrenediol, 5-ethenyl-9,10-dihydro-1,6-dimethyl-

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Phenanthrenes: 27
        juncusol: 4
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Phenanthrenes: 27
    - juncusol: 4

Experts

1.	Hohmann, Judit: 2 articles (05/2019 - 08/2018)
2.	Vasas, Andrea: 2 articles (05/2019 - 08/2018)
3.	Zupkó, István: 2 articles (05/2019 - 08/2018)
4.	Chang, Fang-Rong: 1 article (05/2019)
5.	Kuo, Ching-Ying: 1 article (05/2019)
6.	Ocsovszki, Imre: 1 article (05/2019)
7.	Schelz, Zsuzsanna: 1 article (05/2019)
8.	Tóth, Barbara: 1 article (05/2019)
9.	Wang, Hui-Chun: 1 article (05/2019)
10.	Bogdanov, Anita: 1 article (08/2018)

Related Diseases

1.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 10/01/1985 - "Confirmed in vitro cytotoxic activity that parallels antimicrobial activity was found for juncusol (1a), desvinyljuncusol (2h), 2-hydroxy-3-methyl-9,10-dihydrophenanthrene (3h), and the quaternary dimethyl[(phenylthio)methyl]ammonium salts 2d and 3d in a human lymphoblastic leukemia cell culture (CCRF-CEM, IC50 = nt, 9.3, nt, 0.9 and 1.4 microgram/mL, respectively), B-16 mouse melanoma cell culture (IC50 = 12.5, 17.5, 27.7, 0.3, and 0.5 microgram/mL, respectively), and L-1210 mouse lymphocytic leukemia cell culture (IC50 = 13.8, 10.2, 24.5, 1.3, and 3.7 micrograms/mL, respectively). "
2.	Neoplasms (Cancer) 04/10/2014 - "Juncunol was identified as the active compound and for the first time was shown to display selective in vitro cytotoxicity towards various human cancer cells."
3.	Melanoma (Melanoma, Malignant) 10/01/1985 - "Confirmed in vitro cytotoxic activity that parallels antimicrobial activity was found for juncusol (1a), desvinyljuncusol (2h), 2-hydroxy-3-methyl-9,10-dihydrophenanthrene (3h), and the quaternary dimethyl[(phenylthio)methyl]ammonium salts 2d and 3d in a human lymphoblastic leukemia cell culture (CCRF-CEM, IC50 = nt, 9.3, nt, 0.9 and 1.4 microgram/mL, respectively), B-16 mouse melanoma cell culture (IC50 = 12.5, 17.5, 27.7, 0.3, and 0.5 microgram/mL, respectively), and L-1210 mouse lymphocytic leukemia cell culture (IC50 = 13.8, 10.2, 24.5, 1.3, and 3.7 micrograms/mL, respectively). "
4.	Lymphoid Leukemia 10/01/1985 - "Confirmed in vitro cytotoxic activity that parallels antimicrobial activity was found for juncusol (1a), desvinyljuncusol (2h), 2-hydroxy-3-methyl-9,10-dihydrophenanthrene (3h), and the quaternary dimethyl[(phenylthio)methyl]ammonium salts 2d and 3d in a human lymphoblastic leukemia cell culture (CCRF-CEM, IC50 = nt, 9.3, nt, 0.9 and 1.4 microgram/mL, respectively), B-16 mouse melanoma cell culture (IC50 = 12.5, 17.5, 27.7, 0.3, and 0.5 microgram/mL, respectively), and L-1210 mouse lymphocytic leukemia cell culture (IC50 = 13.8, 10.2, 24.5, 1.3, and 3.7 micrograms/mL, respectively). "
5.	Herpes Simplex 08/20/2018 - "Moreover, juncusol (Compound 5) proved to possess significant antiviral activity against the herpes simplex 2 virus (HSV-2)."

Related Drugs and Biologics

1.	Ammonium Compounds
2.	Salts
3.	Phenanthrenes
4.	Antiviral Agents (Antivirals)
5.	Antineoplastic Agents (Antineoplastics)