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vinpocetine

Subscribe to New Research on vinpocetine

whole issue of Arzneim Forsch (23 articles) discuss this drug; Arzneim Forsch 26(10a);1976; RN given refers to parent cpd with unspecified isomeric designation

Also Known As:

Armstrong brand of vinpocetine; Cavinton; Celltech brand of vinpocetine; Kavinton; RGH-4405; TCV-3B; ethyl apovincaminate; ethyl apovincaminate tartrate (1:1); ethyl apovincaminate, (+-)-isomer; ethyl apovincaminate, (16alpha)-isomer; ethyl apovincaminate, (3alpha,16alpha)-isomer; ethyl apovincaminate, 2-oxopentanedioate (1:1); ethyl apovincaminate, 3H-labeled; eburnamenine-14-carboxylic acid, ethyl ester, (3 alpha,16 alpha)-

Networked: 181 relevant articles (20 outcomes, 46 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- Alkaloids: 1065
  - Indole Alkaloids: 36
    - Secologanin Tryptamine Alkaloids: 55
      - Vinca Alkaloids: 337
        vinpocetine: 181
- 2-Ring Heterocyclic Compounds
  - Indoles: 95
    - Indole Alkaloids: 36
      - Secologanin Tryptamine Alkaloids: 55
        Vinca Alkaloids: 337
        vinpocetine: 181

Experts

1.	Vas, Adám: 7 articles (09/2012 - 11/2002)
2.	Sitges, María: 6 articles (09/2014 - 06/2004)
3.	Gulyás, Balázs: 6 articles (09/2012 - 11/2002)
4.	Yan, Chen: 5 articles (12/2015 - 05/2010)
5.	Nekrassov, Vladimir: 5 articles (11/2008 - 06/2004)
6.	Li, Jian-Dong: 4 articles (06/2015 - 05/2010)
7.	Halldin, Christer: 4 articles (09/2012 - 11/2002)
8.	Hillert, Jan: 3 articles (09/2012 - 01/2008)
9.	Csillik, Bertalan: 3 articles (05/2010 - 01/2007)
10.	Bereczki, D: 3 articles (01/2008 - 01/2000)

Related Diseases

1.	Brain Ischemia (Cerebral Ischemia) 04/01/1987 - "The antihypoxic effects with vinpocetine and related drugs in this model correlate with protective effects observed in animal models of cerebral ischemia and with therapeutic effects in patients with compromised cerebral blood flow. " 01/01/2008 - "[The results of clinical study of cavinton efficacy inpatients with chronic brain ischemia]." 04/30/2014 - "Vinpocetine decreases the expression of NF-κB and TNF-α and inhibits the inflammatory response after cerebral ischemia-reperfusion." 04/30/2014 - "Wistar rats were randomly assigned to a control group, (n=40) a cerebral ischemia-reperfusion group (n=52) and a vinpocetine cerebral ischemia-reperfusion group (n=52). " 09/01/2009 - "The membrane, antioxidant and functional effects of vinpocetine and a-tocopherol have been investigated under conditions of acute experimental cerebral ischemia in rats. "
2.	Stroke (Strokes) 07/22/2007 - "There is no evidence that vinpocetine treatment is applicable in acute ischemic stroke, only few study with low patient number showed a slight but significant improvement in the patients conditions. " 05/01/1986 - "In the group of severe strokes better results were observed after Cavinton, --out of 14 patients 2 died and 12 improved. " 09/15/2012 - "Evolution of microglial activation in ischaemic core and peri-infarct regions after stroke: a PET study with the TSPO molecular imaging biomarker [((11))C]vinpocetine." 01/01/2008 - "Unconfounded randomised trials of vinpocetine compared with placebo, or any other reference treatment, in people with acute ischaemic stroke. " 11/24/2002 - "The brain regions showing increased uptake in the human brain correspond to those in which vinpocetine has previously been shown to induce elevated metabolism and blood flow by PET clinical studies in patients with chronic ischaemic post-stroke condition."
3.	Anoxia (Hypoxia) 04/01/1987 - "Protective effects of vinpocetine and structurally related drugs on the lethal consequences of hypoxia in mice." 09/01/1991 - "Besides, the adaptational role of 2,3-biphosphoglycerate increases due to normalization of blood pH under the effect of Cavinton in the first 3 hours of hypoxia." 09/01/1991 - "[Mechanisms of emergency adaptation of the erythron system to hypoxia in rats receiving cavinton]." 04/01/1987 - "Vinpocetine has been compared with 3 structurally related drugs for activity in protecting mice from hypoxia-induced lethality upon i.p. " 01/01/1986 - "A suggestion is made that the mechanism of the anticonvulsive action of cavinton may be explained both by the normalization of the cerebral blood flow and elimination of hypoxia and by the fact that the drug may possess anticonvulsive properties unrelated to the normalization of the cerebral hemodynamics."
4.	Epilepsy (Aura) 12/01/2004 - "Vinpocetine could be a promising alternative for the treatment of epilepsy." 01/01/2001 - "[Cavinton in epilepsy treatment and prevention]." 07/01/1986 - "It is reasonable to test cavinton as a drug for treating some forms of epilepsy." 01/01/1986 - "[Use of cavinton in epilepsy]." 07/01/2014 - "Vinpocetine was effective in improving memory and concentration of patients with epilepsy and dementia although the efficacy was minimal in demented patients."
5.	Dementia (Dementias) 11/01/2003 - "In three studies of older adults with memory problems associated with poor brain circulation or dementia-related disease, vinpocetine produced significantly more improvement than a placebo in performance on global cognitive tests reflecting attention, concentration, and memory. " 01/01/2003 - "The three studies included in the review involved a total of 583 people with dementia treated with vinpocetine or placebo. " 01/01/2003 - "The manufacturers of vinpocetine were asked for information on trials of vinpocetine for dementia. " 05/01/2002 - "In three studies of older adults with memory problems associated with poor brain circulation or dementia-related disease, vinpocetine produced significantly more improvement than a placebo in performance on global cognitive tests reflecting attention, concentration, and memory. " 07/30/2007 - "Vinpocetine has been widely used in the treatment of ischaemic cerebrovascular diseases and dementias of vascular type. "

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Related Therapies and Procedures

1.	Intravenous Infusions
2.	Trabeculectomy (Trabeculoplasty)
3.	Lasers (Laser)
4.	Oral Administration
5.	Heterologous Transplantation (Xenotransplantation)