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dehydrocurvularin

Also Known As:

alpha,beta-dehydrocurvularin; beta,gamma-dehydrocurvularin; 4,5,6,7-tetrahydro-11,13-dihydroxy-4-methyl-2H-3- benzoxacyclododecin-2,10-(1H)-dione

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Resorcinols: 4
        Zearalenone: 227
        dehydrocurvularin: 4
- Lactones: 1549
  - Zearalenone: 227
    - dehydrocurvularin: 4
Biological Factors: 2472
- Biological Toxins: 20
  - Mycotoxins: 1745
    - Zearalenone: 227
      - dehydrocurvularin: 4

Experts

1.	Clasohm, Jasmin: 1 article (01/2017)
2.	Erkel, Gerhard: 1 article (01/2017)
3.	Felix, Silke: 1 article (01/2017)
4.	Klotz, Markus: 1 article (01/2017)
5.	Lilischkis, Rainer: 1 article (01/2017)
6.	Marx, Lisa: 1 article (01/2017)
7.	Schreiber, Dominik: 1 article (01/2017)
8.	Schäfer, Karl-Herbert: 1 article (01/2017)
9.	Schäfer, Maximilian: 1 article (01/2017)
10.	Weyland, Maximilian: 1 article (01/2017)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2009 - "With the anti-microbial and anti-tumor composite screening model, bioassay-guided fractionation led to the isolation of two structurally related bioactive compounds, curvularin and alphabeta-dehydrocurvularin, from ethyl acetate extract of Eupenicillium sp. associated with marine sponge Axinella sp. Further study on the structure-activity relationship demonstrated that both compounds exhibited differences in bioactive profiles which are highly associated with their minor structural differences. "
2.	Inflammation (Inflammations) 01/01/2017 - "In the present study, we investigated the anti-inflammatory effects of the fungal metabolites, galiellalactone, and dehydrocurvularin in both an in vitro intestinal inflammation model, as well as in isolated myenteric plexus and enterocyte cells. "
3.	Stomach Neoplasms (Stomach Cancer) 01/01/2023 - "The natural product dehydrocurvularin induces apoptosis of gastric cancer cells by activating PARP-1 and caspase-3."
4.	Adenocarcinoma 01/01/2022 - "Antifungal activity of dehydrocurvularin for Candida spp. through the inhibition of adhesion to human adenocarcinoma cells."

Related Drugs and Biologics

1.	galiellalactone
2.	curvularin
3.	ethyl acetate
4.	Caspase 3 (Caspase-3)