HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

NSC 153174

RN given refers to (cis)-isomer

Also Known As:

NSC 153174, (trans)-isomer; cis-acid; cis-4-((((2-chloroethyl)nitrosamino) carbonyl)amino)-cyclohexanecarboxylic acid

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Nitrosourea Compounds: 21
      - Lomustine: 1182
        NSC 153174: 2
- Nitroso Compounds: 446
  - Nitrosourea Compounds: 21
    - Lomustine: 1182
      - NSC 153174: 2

Related Diseases

1.	Lymphoma (Lymphomas) 11/01/1977 - "Our studies have shown that cis-acid is as effective in killing cultured human lymphoma cells as other nitrosoureas, but possibly with a mechanism different from that of these compounds. " 11/01/1977 - "The lethal effects of 4-(3-(2-chloroethyl)-3-nitrosoureido)-cis-cyclohexanecarboxylic acid (cis-acid), a water-soluble nitrosourea derivative, were investigated on a human lymphoma cell line. "
2.	Neoplasms (Cancer) 01/01/1986 - "The major endpoint assessed was tumor cure and was grouped as follows: (1) high (greater than or equal to 80%), achieved with BCNU, MeCCNU, CCNU, CLZ, ACNU, FCNU, PCNU, and cis-acid; (2) medium (40- less than 80%), obtained with GANU, NSC-88104, and GCNU, and (3) low or nil (less than 40%), shown by CNU and STZN. "

Related Drugs and Biologics

1.	Nimustine
2.	Semustine
3.	Lomustine (CCNU)
4.	Carmustine (FIVB)
5.	Acids
6.	1- (2- chloroethyl)- 3- (2,6- dioxo- 3- piperidinyl)- 1- nitrosourea
7.	1- (2- fluoroethyl)- 3- cyclohexyl- 1- nitrosourea
8.	1-(2-chloroethyl)-1-nitrosourea (CNU)
9.	GCNU
10.	GANU