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4-amino-5-hexynoic acid

structure

Also Known As:

4-aminohexynoate; RMI 71645; RMI-71645; gamma-acetylenic GABA; gamma-acetylenic-GABA; 4-aminohex-5-ynoic acid

Networked: 26 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkynes: 217
      - 4-amino-5-hexynoic acid: 26
- Carboxylic Acids: 973
  - Acyclic Acids
    - Caproates: 7
      - Aminocaproates: 1
        4-amino-5-hexynoic acid: 26
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Aminocaproates: 1
    - 4-amino-5-hexynoic acid: 26

Experts

1.	Deeks, J J: 2 articles (01/2001 - 01/2000)
2.	McGrath, J J: 2 articles (01/2001 - 01/2000)
3.	Soares, K V: 2 articles (01/2001 - 01/2000)
4.	Alabed, Samer: 1 article (04/2011)
5.	Latifeh, Youssef: 1 article (04/2011)
6.	Mohammad, Husam Aldeen: 1 article (04/2011)
7.	Rifai, Abdullah: 1 article (04/2011)
8.	Deeks, J: 1 article (10/2004)
9.	Rathbone, J: 1 article (10/2004)
10.	Soares, K: 1 article (10/2004)

Related Diseases

1.	Tardive Dyskinesia 12/01/1980 - "gamma-Acetylenic GABA in tardive dyskinesia." 01/01/1980 - "Gamma-Acetylenic GABA in tardive dyskinesia." 12/01/1980 - "The effects of increasing brain GABA with gamma-acetylenic GABA (GAG), a drug that inhibits GABA transaminase, were evaluated in ten patients with stable tardive dyskinesia during a blind placebo-controlled trial. " 01/01/1980 - "gamma-Acetylenic GABA, a drug that increases brain GABA via GABA transaminase inhibition, was evaluated in a blind placebo-controlled trial in 10 patients with stable tardive dyskinesia. " 04/13/2011 - "To determine the clinical effects of GABA agonist drugs (baclofen, gamma-vinyl-GABA, gamma-acetylenic-GABA, progabide, muscimol, sodium valproate and tetrahydroisoxazolopyridine (THIP) for people with schizophrenia or other chronic mental illnesses who also developed neuroleptic-induced tardive dyskinesia. "
2.	Parkinsonian Disorders (Parkinsonism) 09/01/1988 - "The GABA part of the TD hypothesis has been tested with different GABA agonists such as gamma-acetylenic GABA, gamma-vinyl GABA and THIP, but most studies suggest that the therapeutic effect of these drugs in TD is limited and maybe secondary to parkinsonism and sedation. "
3.	Seizures (Absence Seizure) 10/01/1998 - "We have now examined a similar but approximately 20 times more potent toxin, gamma-acetylenic GABA (GAG), for its ability to produce seizures and neurodegeneration in the rat EC. " 06/01/1983 - "Our results combined with previous reports of the effects of gamma-butyrolactone and gamma-acetylenic GABA on amygdaloid kindled seizures indicate that the KCS is more susceptible to GABAnergic and cataleptic inhibition than is the fully developed amygdaloid kindled seizures. " 10/02/1980 - "The influence in rabbits and rats of gamma-acetylenic GABA on seizures generated by pentylenetetrazol." 04/01/1980 - "The newly synthesized GABA-transaminase inhibitor, gamma-acetylenic GABA (GAG) administered on four consecutive days (100 mg/kg, followed by 50 mg/kg, i.p.) was found to either significantly reduce, or eliminate entirely, the behavioral seizures normally produced by amygdala stimulation. " 09/15/1986 - "gamma-Acetylenic GABA antagonizes the decrease in synaptosomal GABA concentrations but not the seizures induced by 3-mercaptopropionic acid in rats."
4.	Schizophrenia (Dementia Praecox) 04/13/2011 - "To determine the clinical effects of GABA agonist drugs (baclofen, gamma-vinyl-GABA, gamma-acetylenic-GABA, progabide, muscimol, sodium valproate and tetrahydroisoxazolopyridine (THIP) for people with schizophrenia or other chronic mental illnesses who also developed neuroleptic-induced tardive dyskinesia. " 10/18/2004 - "To determine the effects of GABA agonist drugs (baclofen, gamma-vinyl-GABA, gamma-acetylenic-GABA, progabide, muscimol, sodium valproate and tetrahydroisoxazolopyridine (THIP)) for people with antipsychotic-induced tardive dyskinesia (TD) and schizophrenia or other chronic mental illnesses. " 01/01/2001 - "To determine the effects of GABA agonist drugs (baclofen, gamma-vinyl-GABA, gamma-acetylenic-GABA, progabide, muscimol, sodium valproate and tetrahydroisoxazolopyridine (THIP)) for people with neuroleptic-induced tardive dyskinesia (TD) and schizophrenia or other chronic mental illnesses. " 01/01/2000 - "To determine the effects of GABA agonist drugs (baclofen, gamma-vinyl-GABA, gamma-acetylenic-GABA, progabide, muscimol, sodium valproate and tetrahydroisoxazolopyridine (THIP)) in people with neuroleptic-induced tardive dyskinesia (TD) and schizophrenia or other chronic mental illnesses. "
5.	Mental Disorders (Mental Disorder) 04/13/2011 - "To determine the clinical effects of GABA agonist drugs (baclofen, gamma-vinyl-GABA, gamma-acetylenic-GABA, progabide, muscimol, sodium valproate and tetrahydroisoxazolopyridine (THIP) for people with schizophrenia or other chronic mental illnesses who also developed neuroleptic-induced tardive dyskinesia. " 10/18/2004 - "To determine the effects of GABA agonist drugs (baclofen, gamma-vinyl-GABA, gamma-acetylenic-GABA, progabide, muscimol, sodium valproate and tetrahydroisoxazolopyridine (THIP)) for people with antipsychotic-induced tardive dyskinesia (TD) and schizophrenia or other chronic mental illnesses. " 01/01/2001 - "To determine the effects of GABA agonist drugs (baclofen, gamma-vinyl-GABA, gamma-acetylenic-GABA, progabide, muscimol, sodium valproate and tetrahydroisoxazolopyridine (THIP)) for people with neuroleptic-induced tardive dyskinesia (TD) and schizophrenia or other chronic mental illnesses. " 01/01/2000 - "To determine the effects of GABA agonist drugs (baclofen, gamma-vinyl-GABA, gamma-acetylenic-GABA, progabide, muscimol, sodium valproate and tetrahydroisoxazolopyridine (THIP)) in people with neuroleptic-induced tardive dyskinesia (TD) and schizophrenia or other chronic mental illnesses. "

Related Drugs and Biologics

1.	gamma-Aminobutyric Acid (GABA)
2.	4-Aminobutyrate Transaminase (4 Aminobutyrate Transaminase)
3.	Vigabatrin
4.	GABA Agonists (GABA Receptor Agonists)
5.	gaboxadol (THIP)
6.	Therapeutic Uses
7.	Valproic Acid (Depakote)
8.	Muscimol
9.	progabide (Gabrene)
10.	Antipsychotic Agents (Antipsychotics)