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nitrosobis(2-oxopropyl)amine (NBOP)

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structure

Also Known As:

NBOP; 2,2'-BOP; 2,2'-dioxopropyl-N-propylnitrosamine; 2,2'-dioxopropylnitrosamine; BOP cpd; N-nitroso-2-oxopropylpropylamine; N-nitrosobis(2-oxopropyl)amine; N-nitrosobis(2-oxypropyl)amine; bis(2-oxopropyl)nitrosamine; di-oxo-di-n-propylnitrosamine; 2-Propanone, 1,1'-(nitrosoimino)bis-

Networked: 126 relevant articles (0 outcomes, 9 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Nitroso Compounds: 319
  - Nitrosamines: 522
    - nitrosobis(2-oxopropyl)amine: 126

Experts

1.	Mutoh, Michihiro: 6 articles (03/2013 - 08/2007)
2.	Tsujiuchi, Toshifumi: 6 articles (10/2009 - 02/2003)
3.	Wakabayashi, Keiji: 5 articles (05/2012 - 08/2007)
4.	Takahashi, Mami: 4 articles (03/2013 - 08/2007)
5.	Honoki, Kanya: 4 articles (10/2009 - 10/2005)
6.	Imai, Toshio: 3 articles (03/2013 - 07/2010)
7.	Sugimura, Takashi: 3 articles (07/2010 - 08/2007)
8.	Shimizu, Kyoko: 3 articles (02/2008 - 10/2005)
9.	Fujii, Hiromasa: 3 articles (02/2008 - 10/2005)
10.	Ulrich, A: 2 articles (07/2012 - 02/2000)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 03/01/1990 - "Our previous studies have shown that pancreatic cancer induced in Syrian hamsters by N-nitrosobis(2-oxopropyl)amine (BOP) shows remarkable similarities with the human disease in morphologic and biologic characteristics. " 03/01/2013 - "Selective inhibitors of iNOS and COX-2 suppress pancreatic cancer development in a chemical carcinogenesis model of hamsters treated with N-nitrosobis(2-oxopropyl)amine (BOP). " 05/01/2012 - "Hamsters were subcutaneously injected with the pancreatic duct carcinogen N-nitrosobis(2-oxopropyl)amine to induce pancreatic cancer. " 01/01/2006 - "Two normal pancreases and 15 pancreatic cancers induced by N-nitrosobis(2-oxypropyl)amine (BOP) were processed for immunohistochemistry using a monoclonal Oct4 antibody at a concentration of 1:500. " 11/01/2002 - "Hamster pancreatic cancer was initiated at time 0 with N-nitrosobis(2-oxopropyl)amine. "
2.	Neoplasms (Cancer) 02/01/2000 - "Thus far no tumors of giant cell type have been induced by the in vitro treatment of hamster pancreatic ductal cells with the potent pancreatic carcinogen N-nitrosobis(2-oxopropyl)amine (BOP). " 01/01/2000 - "All animals received N-nitrosobis(2-oxopropyl)amine (BOP) to initiate pancreaticobiliary cancer. " 12/01/1994 - "Tumor induction in mice administered neonatally with bis(2-oxopropyl)nitrosamine." 09/01/1991 - "This mutation is identical with that reported for pancreatic tumors of Syrian hamsters induced by N-nitrosobis(2-oxopropyl)amine." 01/01/1991 - "N-Nitrosobis(2-oxopropyl)amine (BOP) and N-nitroso(2-hydroxypropyl)(2-oxypropyl)amine (HPOP) induce pancreatic tumors in the Syrian hamster. "
3.	Adenocarcinoma 07/01/2012 - "Long-term in vitro culture of hamster pancreatic β-cells and induction of adenocarcinoma by treatment with N-nitrosobis(2-oxopropyl)amine." 10/01/2009 - "To evaluate an involvement of LKB1 gene alteration during pancreatic carcinogenesis, mutations in the LKB1 gene in hamster pancreatic duct adenocarcinomas (PDAs) induced by N-nitrosobis(2-oxopropyl)amine (BOP) were investigated. " 10/01/2009 - "Mutations of LKB1 gene in pancreatic ductal adenocarcinomas induced by N-nitrosobis(2-oxopropyl)amine in hamsters." 02/01/2008 - "Alterations of the Rassf1a gene were investigated in pancreatic duct adenocarcinomas (PDAs) induced by N-nitrosobis(2-oxopropyl)amine (BOP) in hamsters. " 02/01/2008 - "Reduced expression of the Rassf1a gene and its aberrant DNA methylation in pancreatic duct adenocarcinomas induced by N-nitrosobis(2-oxopropyl)amine in hamsters."
4.	Carcinoma (Carcinomatosis) 12/01/1980 - "The findings in this study confirm that the pancreatic carcinoma induced by N-nitrosobis(2-oxopropyl)amine in Syrian hamsters is of duct cell origin. " 12/01/2004 - "Aberrant transcription of FHIT gene in intrahepatic cholangiocellular carcinomas induced by N-nitrosobis(2-oxopropyl)amine in hamsters." 10/01/1997 - "In our laboratory, we have developed a new model of carcinoma of the bile duct in Syrian golden hamsters, using N-nitrosobis(2-oxopropyl)amine (BOP). " 09/16/1997 - "An experimental model for the induction of extrahepatic biliary duct carcinomas in hamsters given cholecystoduodenostomy with dissection of the extrahepatic duct at the distal end of the common duct (CDDB) followed by N-nitrosobis(2-oxopropyl)amine (BOP) has been reported [Tajima et al. (1994) Jpn. " 09/16/1997 - "Mutations of K-ras but not p53 genes in biliary duct and pancreatic duct carcinomas induced in hamsters by cholecystoduodenostomy with dissection of the common duct followed by N-nitrosobis(2-oxopropyl)amine."
5.	Hyperlipidemias (Hyperlipidemia) 10/01/2007 - "In the present study, effects of diabetes/hyperlipidemia on N-nitrosobis(2-oxopropyl)amine (BOP)-induced cancer development were examined in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, model animals for non-insulin-dependent diabetes mellitus and Long-Evans Tokushima Otsuka (LETO) rats, appropriate controls. "

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2.	Somatostatin (Somatotropin Release-Inhibiting Factor)
3.	Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))
4.	Secretin
5.	nitroxy-butyl-acetylsalicylic acid
6.	Linoleic Acid (Linoleate)
7.	Cholecystokinin (Pancreozymin)
8.	Bombesin
9.	Maxepa
10.	Antigens

Related Therapies and Procedures

1.	Castration
2.	Subcutaneous Injections
3.	Injections
4.	Caloric Restriction
5.	Transplants (Transplant)