lipid peroxidation inhibitor

a mixture of free carboxylic acids (major components comprising 92% of the total fatty acids); induced by CCl(4) in rat liver soluble fraction; also glutathione-dependent factor isolated from human red cell membrane

Networked: 42 relevant articles (1 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Babu, Suma: 1 article (10/2022)
2.	Berry, James D: 1 article (10/2022)
3.	Bruno, Margaret: 1 article (10/2022)
4.	Burke, Katherine M: 1 article (10/2022)
5.	Cudkowicz, Merit E: 1 article (10/2022)
6.	D'Agostino, Derek: 1 article (10/2022)
7.	Doyle, Michael: 1 article (10/2022)
8.	Gelevski, Dario: 1 article (10/2022)
9.	Hochman, Alison: 1 article (10/2022)
10.	Kane, Geli: 1 article (10/2022)

Related Diseases

1.	Myocardial Infarction 01/01/1992 - "[The efficacy of the combined use of a lipid peroxidation inhibitor and a stimulator of the lymphatic drainage of the heart in the treatment of the acute period of myocardial infarction]." 01/01/1993 - "[Effectiveness of combined use of a lipid peroxidation inhibitor and a lymphatic drainage stimulant in intensive care of acute myocardial infarct]." 10/01/1999 - "Combination of a calcium antagonist, a lipid-peroxidation inhibitor, and an angiotensin AT1-receptor antagonist provides additive myocardial infarct size-limiting effect in pigs." 06/01/1982 - "DNA damage and repair in the nonischemic area of the heart were analyzed after experimental myocardial infarction to evaluate the effect on these processes of the beta-blocker inderal and lipid peroxidation inhibitor ionol. "
2.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/04/1994 - "The aim of this study was to evaluate the effect of 21-aminosteroid lipid peroxidation inhibitor, U74006F, on ischaemic brain tissue damage using the rat middle cerebral artery occlusion model. " 01/04/1994 - "Effect of 21-aminosteroid lipid peroxidation inhibitor, U74006F, in the rat middle cerebral artery occlusion model." 02/01/1996 - "The purpose of the present investigation was to determine if post-ischemic treatment with the 21-aminosteroid lipid peroxidation inhibitor tirilazad mesylate (U-74006F) could affect reperfusion brain edema during the first 3h following a 3h period of middle cerebral artery occlusion-induced focal ischemia in cynomolgus monkeys. " 06/01/2007 - "The aim of the present study was to assess the effect of post ictal administration of the pyrrolopyrimidine lipid peroxidation inhibitor, U-101033E, on infarct volume and neuronal and astrocytic metabolism in rats with transient middle cerebral artery occlusion (MCAO). " 06/01/2007 - "Effect of the pyrrolopyrimidine lipid peroxidation inhibitor U-101033E on neuronal and astrocytic metabolism and infarct volume in rats with transient middle cerebral artery occlusion."
3.	Ischemia 06/01/1998 - "The lipid peroxidation inhibitor H290/51 attenuated cardiac injury induced by ischemia-reperfusion." 06/01/1995 - "Beneficial effects of H290/51, a new lipid peroxidation inhibitor, on functional recovery after ischemia and reperfusion in isolated cold-arrested rat hearts." 06/01/1995 - "In the present study, a newly synthetized lipid peroxidation inhibitor H290/51 [cis-7methyl-9-methoxy-5,5a,b,10b- tetrahydroindeno(2,1-6 indole)] was evaluated for its effects on myocardial functional recovery during reperfusion after 30-min global ischemia in isolated cold-arrested rat hearts. " 03/15/1998 - "The lipid peroxidation inhibitor indenoindole H290/51 protects myocardium at risk of injury induced by ischemia-reperfusion." 11/01/1996 - "Because lipid peroxidation may cause cell membrane injury after ischemia and reperfusion, we hypothesized that the administration of a lipid peroxidation inhibitor lazaroid (U74500A) would result in an improvement of functional recovery after the 24-hour preservation period. "
4.	Brain Ischemia (Cerebral Ischemia) 06/01/1998 - "Postischemic application of lipid peroxidation inhibitor U-101033E reduces neuronal damage after global cerebral ischemia in rats." 08/01/1988 - "21-Aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils." 12/01/2016 - "A rat model of cerebral ischemia/reperfusion injury was constructed and intervened with monosialotetrahexosylganglioside(5mg/kg) and lipid peroxidation inhibitor U-101033E(40mg/kg). " 06/01/1992 - "We examined the cytoprotective effect of the lipid peroxidation inhibitor tirilazad mesylate (U74006F) in rodent models of neocortical infarction induced by transient and permanent focal cerebral ischemia. " 09/01/2000 - "This study investigates the effects of acamprosate, a glutamatergic modulator, and the lipid peroxidation inhibitor U-101033E on neurological outcome following incomplete cerebral ischemia and reperfusion in rats. "
5.	Infarction (Infarctions) 06/01/1992 - "We examined the cytoprotective effect of the lipid peroxidation inhibitor tirilazad mesylate (U74006F) in rodent models of neocortical infarction induced by transient and permanent focal cerebral ischemia. " 01/01/1999 - "A combination of candesartan, felodipine, and the lipid peroxidation inhibitor H290/51 produced a more pronounced infarct limitation than each of these agents alone. " 10/01/1999 - "These results demonstrate that a combination of a calcium antagonist, a lipid-peroxidation inhibitor, and an angiotensin AT1-receptor antagonist has an additive effect on infarct limitation, indicating that combined therapy with agents having different pharmacologic modes of action may provide better cardioprotection than any of the drugs alone. " 06/01/2007 - "The aim of the present study was to assess the effect of post ictal administration of the pyrrolopyrimidine lipid peroxidation inhibitor, U-101033E, on infarct volume and neuronal and astrocytic metabolism in rats with transient middle cerebral artery occlusion (MCAO). " 06/01/2007 - "Effect of the pyrrolopyrimidine lipid peroxidation inhibitor U-101033E on neuronal and astrocytic metabolism and infarct volume in rats with transient middle cerebral artery occlusion."

Related Drugs and Biologics

1.	tirilazad
2.	U 101033E (U-101033E)
3.	Reactive Oxygen Species (Oxygen Radicals)
4.	F2-Isoprostanes (F2 Isoprostanes)
5.	Nitric Oxide Synthase (NO Synthase)
6.	Lipids
7.	Hydrogen Peroxide (Hydroperoxide)
8.	Arginine (L-Arginine)
9.	Acamprosate (Campral)
10.	pyrrolopyrimidine

Related Therapies and Procedures

1.	Axotomy
2.	Therapeutics
3.	Critical Care (Surgical Intensive Care)