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filamins

found in smooth muscle & non-muscle cells; RefSeq NM_001456 (FLNA protein), NM_001458 (FLNC protein), NM_001457 (FLNB)

Also Known As:

280 kDa actin-binding protein; ABP-278 protein, human; FLN1protein, human; FLN2 protein, human; FLNA protein, human; FLNB protein, human; FLNC protein, human; alpha-filamin; beta-filamin; cheerio protein, Drosophila; cher protein, Drosophila; filamin; filamin 1; filamin 1-like protein; filamin 2; filamin A; filamin A, alpha (actin binding protein 280), human; filamin B; filamin B, beta (actin binding protein 278), human; filamin C; filamin C, gamma (actin binding protein 280), human; merofilamins

Networked: 251 relevant articles (3 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	van der Ven, Peter F M: 14 articles (12/2015 - 01/2003)
2.	Fürst, Dieter O: 13 articles (12/2015 - 01/2003)
3.	Robertson, Stephen P: 10 articles (12/2015 - 07/2006)
4.	Kley, Rudolf A: 8 articles (12/2015 - 08/2005)
5.	Vorgerd, Matthias: 7 articles (12/2015 - 08/2005)
6.	Goldfarb, Lev G: 7 articles (03/2013 - 05/2009)
7.	Akyürek, Levent M: 6 articles (02/2015 - 02/2010)
8.	Shen, Zhiyuan: 6 articles (01/2013 - 02/2004)
9.	Schröder, Rolf: 5 articles (12/2015 - 01/2003)
10.	Kwon, Mijung: 5 articles (12/2014 - 09/2008)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2012 - "These results suggest that filamin-A plays a role in repair of a variety of DNA damage, that lack of filamin-A is a prognostic marker for a better outcome after DNA damage based treatment, and filamin-A can be inhibited to sensitize filamin-A positive cancer cells to therapeutic DNA damage. " 01/20/2015 - "These findings establish a functional role of filamin C in human cancers and these data will be valuable for further study of its mechanisms. " 08/01/2014 - "The aim of this study was to investigate the role of cytoskeleton protein filamin A (FLNA) in SST2 expression and signaling in somatotroph tumor cells. " 02/15/2013 - "In the present study, we identify the actin cross-linking protein Filamin/Cheerio (Cher) as a mediator of malignancy in genetically defined Drosophila tumors. " 06/01/2012 - "This suggests that SZ117 is useful in the study of the pathogenesis of filamin A and that blockage of filamin A by SZ117 might contribute to the anti-tumor angiogenic effect of the monoclonal antibody."
2.	Neoplasm Metastasis (Metastasis) 01/20/2015 - "Silencing of filamin C increased the expression of matrix metallopeptidase 2 and improved the metastasis of prostate cancer in a zebrafish model. " 10/01/2010 - "In summary, our study not only served to uncover molecular mechanisms associated with the metastasis suppressor role of KiSS-1 in bladder cancer but also to reveal the biomarker role of Filamin A in bladder cancer progression and clinical outcome." 01/20/2015 - "Data-mining using public microarray datasets shown that filamin C was significantly reduced in many human primary and metastasis cancers. " 07/01/2014 - "Filamin A interacting protein 1-like inhibits WNT signaling and MMP expression to suppress cancer cell invasion and metastasis." 01/01/2013 - "In this review, we discuss the implications of filamin-A in cancer progression, including metastasis and DNA damage response."
3.	Prostatic Neoplasms (Prostate Cancer) 04/01/2014 - "Filamin A regulates MMP-9 expression and suppresses prostate cancer cell migration and invasion." 12/01/2012 - "Enhancing the effectiveness of androgen deprivation in prostate cancer by inducing Filamin A nuclear localization." 01/20/2015 - "Silencing of filamin C increased the expression of matrix metallopeptidase 2 and improved the metastasis of prostate cancer in a zebrafish model. " 02/01/2009 - "Nuclear versus cytoplasmic localization of filamin A in prostate cancer: immunohistochemical correlation with metastases." 06/01/2015 - "Transcription of Nrdp1 by the androgen receptor is regulated by nuclear filamin A in prostate cancer."
4.	Muscular Diseases (Myopathy) 12/13/2011 - "Linkage studies delineated a 9.76 Mb region on chromosome 7q22.1-q35 containing filamin C (FLNC), a gene previously associated with myofibrillar myopathy. " 12/01/2007 - "Clinical and morphological phenotype of the filamin myopathy: a study of 31 German patients." 03/01/2013 - "Myofibrillar myopathy caused by FLNC/filamin C mutations is characterized by disintegration of myofibrils and a massive formation of protein aggregates within skeletal muscle fibers. " 03/01/2013 - "Impairment of protein degradation in myofibrillar myopathy caused by FLNC/filamin C mutations." 01/01/2013 - "Filamin C-related myopathies: pathology and mechanisms."
5.	Melanoma (Melanoma, Malignant) 01/01/2013 - "Filamin-A (FLNa) has been shown to be a key cross-linker of actin filaments in the leading edge of a motile melanoma cell line, however its role in neutrophils undergoing chemotaxis is unknown. " 03/01/2012 - "Recently, D2R was found to associate with filamin-A (FLNA), a widely expressed cytoskeleton protein with scaffolding properties, in melanoma and neuronal cells. " 02/01/2012 - "By treating a panel of human melanoma cell lines with variable filamin-A expression, we observed a correlation between expression level of filamin-A protein and drug IC(50). " 02/01/2011 - "Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility." 01/01/2010 - "R-Ras regulates migration through an interaction with filamin A in melanoma cells."

Related Drugs and Biologics

1.	filamins
2.	Carrier Proteins (Binding Protein)
3.	Biological Markers (Surrogate Marker)
4.	Proteins (Proteins, Gene)
5.	Desmin
6.	Collagen
7.	Vimentin
8.	Tubulin
9.	mu Opioid Receptors (mu Opioid Receptor)
10.	Keratins (Keratin)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Injections
3.	Drug Therapy (Chemotherapy)