HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
picumast
RN & NM refer to di-HCl
Also Known As:
3,4-dimethyl-7-(4-(p-chlorobenzyl)piperazin-1-yl)propoxycoumarin.di-HCl; BM 15,100; BM 15100; BM-15100; 2H-1-benzopyran-2-one, 7-(3-(4-((4-chlorophenyl)methyl)-1-piperazinyl)propoxy)-3,4-dimethyl-, dihydrochloride
Networked:
11
relevant articles (
3
outcomes,
3
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrans: 130
Benzopyrans: 195
Coumarins: 826
picumast: 11
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzopyrans: 195
Coumarins: 826
picumast: 11
Related Diseases
1.
Asthma (Bronchial Asthma)
10/01/1989 - "
Acceptability, safety and efficacy of picumast dihydrochloride on long-term use in patients with perennial bronchial asthma.
"
10/01/1989 - "
From reasons of these experimental data picumast dihydrochloride may be of a considerable value as a prophylactic agent in allergic bronchial asthma when given orally.
"
10/01/1989 - "
Although this was an open study, analysis of diary card measurements and clinical assessments indicate that picumast dihydrochloride could represent a new and effective prophylactic therapy in the long-term management of bronchial asthma.
"
10/01/1989 - "
Patients given picumast dihydrochloride demonstrated significant improvements compared with baseline in morning and evening peak flow and asthmatic symptoms like morning tightness, cough, dyspnoea, obstruction, number of asthma attacks during night and day, sum of asthmatic symptom scores, in vital capacity and Tiffeneau index, and a significant reduction of inhaled adjuvant medications.
"
10/01/1989 - "
A one-year double-blind clinical study of the efficacy and tolerability of picumast dihydrochloride versus ketotifen in patients with bronchial asthma.
"
2.
Seasonal Allergic Rhinitis (Hay Fever)
10/01/1989 - "
Double-blind multicenter controlled clinical study comparing the efficacy of picumast dihydrochloride versus astemizole and placebo in patients with seasonal allergic rhinitis.
"
10/01/1989 - "
It is concluded that picumast dihydrochloride offers a comparable alternative to terfenadine in the treatment of seasonal allergic rhinitis.
"
10/01/1989 - "
A placebo-controlled comparison of the efficacy and tolerability of picumast dihydrochloride and terfenadine in patients with seasonal allergic rhinitis.
"
10/01/1989 - "
Of 99 evaluable patients with seasonal allergic rhinitis, 33, 35, and 31 were treated with picumast dihydrochloride (3,4-dimethyl-7-[4-(4-chlorbenzyl)piperazine-1-yl]propoxycoumar in dihydrochloride) 1 mg, terfenadine 60 mg, and placebo, respectively, twice daily for 3 weeks.
"
3.
Cough
10/01/1989 - "
Patients given picumast dihydrochloride demonstrated significant improvements compared with baseline in morning and evening peak flow and asthmatic symptoms like morning tightness, cough, dyspnoea, obstruction, number of asthma attacks during night and day, sum of asthmatic symptom scores, in vital capacity and Tiffeneau index, and a significant reduction of inhaled adjuvant medications.
"
4.
Nasal Obstruction
10/01/1989 - "
Picumast dihydrochloride's ability to inhibit nasal obstruction after challenge was significantly better than that of placebo in statistical terms.
"
10/01/1989 - "
The results of this study show that picumast dihydrochloride inhibits nasal obstruction and secretion in patients allergic to grass pollens following allergen challenge.
"
5.
Anaphylaxis (Anaphylactic Shock)
10/01/1989 - "
In conclusion, the inhibition of allergic and anaphylactoid reactions by picumast dihydrochloride can be attributed to a combined inhibition of liberation and action of histamine and other mediators.
"
10/01/1989 - "
After pretreatment of the animals with 3 mg/kg of mepyramine, 10 mg/kg of ketotifen, and 6 mg/kg of picumast dihydrochloride, the inhibitory effect on histamine release from the lung was so marked that both the acute and the protracted anaphylactic shock were completely suppressed.
"
10/01/1989 - "
Picumast dihydrochloride (3,4-dimethyl-7-[4-(4-chlorobenzyl)piperazine-1-yl]propoxycoumarin dihydrochloride) was compared with cromoglycate, ketotifen and mepyramine as an inhibitor of allergic and anaphylactoid reactions.
"
Related Drugs and Biologics
1.
Astemizole
2.
Piperazine
3.
Ketotifen (Ketotifene)
4.
Glucocorticoids
5.
Bronchodilator Agents (Bronchodilators)
6.
Allergens
7.
Pyrilamine (Mepyramine)
8.
Histamine (Histamine Dihydrochloride)
9.
Terfenadine (Seldane)
10.
Indicators and Reagents (Reagents)
Related Therapies and Procedures
1.
Therapeutics
2.
Oral Administration