sporamycin

08/01/1981 - "Sporamycin inhibited the growth of the Meth-A tumor and Balb/c mice, and 12 out of 19 mice were cured. "
08/01/1981 - "A marked neutralization activity against tumor cells was observed by Winn's method using spleen cell of tumor-bearing mice which had been pre- or post-treated with sporamycin. "
08/01/1981 - "Pretreatment of mice with sporamycin produced a remarkable inhibition of tumor growth. "
08/01/1981 - "The role of immunological effects in the antitumor activity of sporamycin activity of sporamycin was studied mainly using the mouse syngeneic tumor, Meth-A. "
01/01/1980 - "The results suggest that enhancement both of antigenicity of the tumor (cells) and of the subsequent immune response of the host by sporamycin may be involved in the cure of the experimental tumor."

04/01/1979 - "Sporamycin did not affect DNA synthesis in vitro catalyzed by partially purified DNA polymerase alpha, beta, and gamma derived from EHRLICH ascites cells."
04/01/1977 - "After nine daily doses of the antibiotic had been given to dd mice bearing Ehrlich ascites carcinoma, significant increase of lifespan was observed at doses of 5.0 approximately 1.3 mg/kg. A marked decrease in tumor size of sarcoma-180 transplanted subcutaneously was observed when the mice were treated by daily or single injection of Sporamycin. "

04/01/1977 - "After nine daily doses of the antibiotic had been given to dd mice bearing Ehrlich ascites carcinoma, significant increase of lifespan was observed at doses of 5.0 approximately 1.3 mg/kg. A marked decrease in tumor size of sarcoma-180 transplanted subcutaneously was observed when the mice were treated by daily or single injection of Sporamycin. "

12/01/1984 - "Pretreatment of mice with sporamycin produced not only a remarkable inhibition of tumor growth but also strengthened the resistance of the host to infection with Pseudomonas aeruginosa. "

11/01/1979 - "(2) The delayed hypersensitivity tested by the foot-pad reaction was positive in tumor-bearing mice treated with sporamycin, and no decrease of foot pad reaction was observed, whereas this reaction decreased remarkably in non-treated tumor-bearing mice. "