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5,10-methylenetetrahydrofolate

Subscribe to New Research on 5,10-methylenetetrahydrofolate

RN refers to parent cpd(L-Glu)-isomer

Also Known As:

5,10-methylene-5,6,7,8-tetrahydrofolate; 5,10-methylenetetrahydrofolate monohydrochloride, (L-Glu)-isomer; 5,10-methylenetetrahydrofolate, (D-Glu)-isomer; 5,10-methylenetetrahydrofolate, (L-Glu)-(S)-isomer; 5,10-methylenetetrahydrofolic acid; CH2H4folate; tetrahydromethylenefolate; N-(4-(3-amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo(1,5-f)pteridin-8(9H)-yl)benzoyl)-L-glutamic acid

Networked: 257 relevant articles (2 outcomes, 38 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kim, Nam Keun: 5 articles (09/2010 - 05/2005)
2.	Tamura, T: 3 articles (05/2002 - 01/2000)
3.	Johanning, G L: 3 articles (05/2002 - 01/2000)
4.	Wenstrom, K D: 3 articles (05/2002 - 01/2000)
5.	Castro, Rita: 2 articles (07/2015 - 06/2009)
6.	Almeida, Sofia: 2 articles (07/2015 - 06/2009)
7.	Cascalheira, José F: 2 articles (07/2015 - 06/2009)
8.	Palmeira, Manuela: 2 articles (07/2015 - 06/2009)
9.	Domingues, Fernanda C: 2 articles (07/2015 - 06/2009)
10.	Ge, J: 2 articles (01/2015 - 07/2013)

Related Diseases

1.	Hyperhomocysteinemia 12/01/2011 - "The aim of the present study was to investigate hyperhomocysteinemia in Tunisian bipolar I patients according to 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism. " 10/01/2011 - "A recessively inherited defect leading to deficiency of the enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) underlies one form of hyperhomocysteinemia. " 02/01/2005 - "Homozygosity for the thermolabile variant of 5,10-methylenetetrahydrofolate reductase (C677T) that causes hyperhomocysteinemia has been reported in 5-15% of general populations. " 07/01/2002 - "Mild hyperhomocysteinemia is associated with homozygosity for the thermolabile variant of 5,10-methylenetetrahydrofolate reductase (MTHFR) and could increase the risk of venous thromboembolic disease (VTD). " 12/01/1998 - "One of the important factors causing hyperhomocysteinemia is decrease of 5,10-Methylenetetrahydrofolate reductase. "
2.	Mesothelioma 11/01/2014 - "The aim of this retrospective multicenter study was to assess the correlation between TS, 5,10-methylenetetrahydrofolate reductase (MTHFR) and excision repair cross-complementing group 1 (ERCC1) gene polymorphisms and the efficacy of pemetrexed-based first-line chemotherapy of mesothelioma patients. "
3.	Stroke (Strokes) 02/10/2014 - "Associations between 5,10-methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and ischemic stroke have been reported (Ariyaratnam et al., 2007; Banerjee et al., 2007; Casas et al., 2004), but the results of these studies are inconsistent. " 01/01/2010 - "Previous studies have demonstrated that a common polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with an increased risk for stroke. " 06/01/2007 - "We compared 5,10-methylenetetrahydrofolate reductase genotypes in groups of subjects presenting ischemic stroke (n = 127) and normal control (n = 126) and found an odds ratio of 1.97 (95% CI, 0.84-4.64) in a multivariate analysis in which results were adjusted to baseline clinical characteristics of study participants. " 06/01/2007 - "A meta-analysis study suggested that the 5,10-methylenetetrahydrofolate reductase 677TT genotype might have a small influence in determining susceptibility to ischemic stroke. " 06/01/2007 - "We found that the homozygous 5,10-methylenetetrahydrofolate reductase C677T genotype was not a risk factor for ischemic stroke in these Brazilian subjects."
4.	Neural Tube Defects (Exencephaly) 01/01/2014 - "This study aims to investigate the single nucleotide polymorphisms (SNPs) of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and neural tube defects (NTDs) in Chinese population. " 08/01/2007 - "There are several studies that have found a positive association between neural tube defects (NTDs) and the common mutation 677C > T of 5,10-methylenetetrahydrofolate reductase (MTHFR), and others that have not found such an association. " 03/01/2012 - "This metaanalysis suggests that 5,10-methylenetetrahydrofolate reductase A1298C polymorphism is not associated with neural tube defect susceptibility in the white population." 03/01/2012 - "The pooled results showed no significant association between 5,10-methylenetetrahydrofolate reductase A1298C polymorphism and neural tube defect susceptibility in any genetic contrast among the 3 groups, except 1 (AC vs AA in neural tube defect patients: odds ratio, 1.16; 95% CI, 1.10-1.32; P = .03), which, however, turned out to be of no statistical significance in the subgroup of the white population (odds ratio, 1.14; 95% CI, 0.98-1.31; P = .08). " 03/01/2012 - "To determine whether 5,10-methylenetetrahydrofolate reductase A1298C polymorphism is associated with neural tube defect susceptibility. "
5.	Neoplasms (Cancer) 12/01/2003 - "Tumors with aberrant DNA methylation of CpG islands within promoter regions of the hMLH1, TIMP3, and ARF genes also contained higher levels of both 5,10-methylenetetrahydrofolate and FH4. " 01/01/1998 - "Plasma drug levels and tumor, gut and marrow 5,10-methylenetetrahydrofolate were assayed. " 07/01/1988 - "In tumor tissue, 5,10-methylenetetrahydrofolate increased eight-fold two to four hours following the two-hour infusion and two-fold during the CI of dl-CF and FUra. " 09/01/2012 - "5,10-Methylenetetrahydrofolate reductase (MTHFR) polymorphisms implicated in the cancer development, but the published studies had yielded inconsistent results. " 07/01/1995 - "The study was terminated on the basis of results showing comparable 5,10-methylenetetrahydrofolate (mTHF) tumor- and tissue levels after administration of MTHF or FA."

Related Drugs and Biologics

1.	Oxidoreductases
2.	Folic Acid (Vitamin M)
3.	pemetrexed (MTA)
4.	Homocysteine
5.	Thymidylate Synthase
6.	Glutathione Transferase (Glutathione S-Transferase)
7.	5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (Methyltetrahydrofolate Homocysteine Methyltransferase)
8.	Prothrombin (Factor II)
9.	Methotrexate (Mexate)
10.	Vitamin B 12 (Cyanocobalamin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Hematopoietic Stem Cell Transplantation
4.	Intravenous Injections
5.	Renal Dialysis (Hemodialysis)