alpha-ketoisocaproic acid

RN given refers to parent cpd

Also Known As:

2-keto-4-methylvalerate; 2-ketoisocaproate; 2-oxo-4-methylpentanoic acid; 2-oxo-4-methylvaleric acid; 2-oxoisocaproic acid; 4-methyl-2-oxopentanoate; 4-methyl-2-oxopentanoic acid; 4-methyl-2-oxovalerate; alpha-keto-isocaproic acid; alpha-ketoisocaproate; alpha-ketoisocaproic acid, calcium salt; alpha-ketoisocaproic acid, sodium salt; alpha-oxoisocaproate; ketoleucine

Networked: 67 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Keto Acids: 203
    - alpha-ketoisocaproic acid: 67

Experts

1.	Wajner, Moacir: 6 articles (09/2007 - 12/2002)
2.	Funchal, Cláudia: 5 articles (09/2007 - 12/2002)
3.	Pessoa-Pureur, Regina: 4 articles (09/2007 - 09/2005)
4.	Zamoner, Ariane: 2 articles (11/2005 - 09/2005)
5.	dos Santos, André Quincozes: 2 articles (11/2005 - 09/2005)
6.	Loureiro, Samanta Oliveira: 2 articles (09/2005 - 12/2002)
7.	Denora, Nunzio: 1 article (02/2016)
8.	Douglas, Justin: 1 article (02/2016)
9.	Lopalco, Antonio: 1 article (02/2016)
10.	Stella, Valentino J: 1 article (02/2016)

Related Diseases

1.	Starvation 06/15/2001 - "Furthermore, Leu and its metabolite alpha-ketoisocaproate have synergistic effects on the enhanced expression of BCKDH subunit genes under sugar starvation. " 09/01/1983 - "Short starvation increased antimycin-sensitive palmitate and 4-methyl-2-oxopentanoate oxidation in liver. " 05/01/1983 - "Starvation of the mother for days 18-20 did not alter CO2 evolution from alpha-ketoisocaproic acid in fetal brain slices but significantly diminished the incorporation of the branched-chain keto acids into leucine. " 02/01/1981 - "We conclude that alpha-ketoisocaproate infusions decrease the nitrogen wasting of starvation, whereas leucine, studied under identical conditions, does not." 05/01/1983 - "During maternal starvation, beta-hydroxybutyrate, by restraining irreversible decarboxylation of alpha-ketoisocaproic acid, could act to salvage the keto acid for conversion to leucine. "
2.	Sepsis (Septicemia) 05/01/1988 - "It has been suggested that leucine and alpha-ketoisocaproic acid (KIA) stimulate protein synthesis and reduce protein breakdown and may be useful in the treatment of muscle catabolism during sepsis. " 05/01/1988 - "Sepsis was induced by cecal ligation and puncture in male Sprague-Dawley rats weighing approximately 70 g and the animals were intravenously infused with one of four isocaloric solutions: group I (N = 16), 8.5% dextrose solution; group II (N = 16), alpha-ketoisocaproic acid (KIA, 5.1 mg/ml) in 8.5% dextrose; group III (N = 16), FreAmine HBC (containing 45% branched-chain amino acids) in 2.5% dextrose; and group IV (N = 17), FreAmine HBC in 2.5% dextrose + KIA (5.1 mg/ml). "
3.	Maple Syrup Urine Disease 01/01/1996 - "alpha-Ketoisocaproate was infused into the brain of free-moving, awake rats by microdialysis to create a microenvironment similar to that found in maple syrup urine disease. " 10/01/1981 - "Maple syrup urine disease: alpha-ketoisocaproate decarboxylation activity in different types of cultured amniotic fluid cells." 11/15/2005 - "In this study we investigated the involvement of Ca2+ on the effects of alpha-ketoisocaproic acid (KIC), the main metabolite accumulating in maple syrup urine disease (MSUD), on the phosphorylating system associated with the intermediate filament (IF) proteins in slices from cerebral cortex of 9-day-old rats. " 09/01/1997 - "Leucine and alpha-ketoisocaproate (alpha-KIC) were perfused at increasing concentrations into rat brain hippocampus by microdialysis to mimic the conditions of maple syrup urine disease. " 01/01/1996 - "The branched-chain amino acids (BCAA) and alpha-ketoisocaproate blood levels were close to those previously observed in neonates with maple syrup urine disease when extracorporeal blood purification was required. "
4.	Neoplasms (Cancer) 08/01/2010 - "Here, we report a preclinical study showing that alpha-ketoisocaproic acid (KIC) can be used to assess molecular signatures of tumors with hyperpolarized MR spectroscopy. "
5.	Birth Weight (Birth Weights) 01/01/2005 - "Leucine kinetics were measured with [5,5,5 D3]leucine tracer in 15 infants receiving Trophamine (group 'T') (mean birth weight 1,263 g) and 22 who received Primene (group 'P') (mean birth weight 1,336 g) during two study periods, within a few hours after birth but before introduction of parenteral amino acid solution, and again at postnatal day 7. The rate of appearance of leucine was calculated from the enrichment of alpha-ketoisocaproic acid in plasma. "

Related Drugs and Biologics

1.	Leucine (L-Leucine)
2.	Proteins (Proteins, Gene)
3.	Acids
4.	3-Hydroxybutyric Acid (beta-Hydroxybutyric Acid)
5.	Oxidoreductases (Dehydrogenase)
6.	Ketone Bodies
7.	Amino Acids
8.	Solutions
9.	amino-acid, glucose, and electrolyte solution (Novamine)
10.	alpha-ketoisovalerate

Related Therapies and Procedures

1.	Punctures
2.	Ligation
3.	Intravenous Infusions
4.	Electrodes (Electrode)
5.	Adrenalectomy