2,3-bis(chloromethyl)-1,4-naphthoquinone

structure

Also Known As:

CMNQ

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Naphthoquinones: 418
        2,3-bis(chloromethyl)-1,4-naphthoquinone: 2
- Quinones: 434
  - Naphthoquinones: 418
    - 2,3-bis(chloromethyl)-1,4-naphthoquinone: 2
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Naphthoquinones: 418
      - 2,3-bis(chloromethyl)-1,4-naphthoquinone: 2

Related Diseases

1.	Neoplasms (Cancer) 01/01/1979 - "In vivo treatment of CMNQ to tumor bearing animals leads to a significant reduction of in vitro S-180 cellular respiration rates. " 01/01/1979 - "The effect of CMNQ was studied on mitochondria isolated from S-180 ascites tumor cells. " 11/01/1976 - "Consistent with the concept that reduction of CMNQ to a hydroquinone results in the generation of an alkylating species (i.e., a quinone methide) was the finding that radioactivity from [14C]CMNQ present in Sarcoma 180 ascites cells was associated with DNA, RNA, and protein for a period of up to 72 hr after exposure to tumor-bearing animals to this agent. "
2.	Sarcoma 180 01/01/1979 - "Effects of the bioreductive alkylating agent 2,3-bis(chloromethyl)-1,4-naphthoquinone on coupled mitochondria isolated from sarcoma 180 ascites cells." 11/01/1976 - "The bioreductive alkylating agent, 2,3-bis(chloromethyl)-1,4-napthoquinone (CMNQ), has been shown to inhibit the growth of Sarcoma 180 ascites cells in vivo. " 11/01/1976 - "This action was due to (a) a drug-induced decrease in intracellular levels of adenosine 5'-triphosphate, presumably resulting from uncoupling of oxidative phosphorylation by CMNQ; and (b) a partial loss of thymidine kinase activity in Sarcoma 180 cells, which did not appear to be due to direct inhibition of the enzyme by the drug. " 11/01/1976 - "Consistent with the concept that reduction of CMNQ to a hydroquinone results in the generation of an alkylating species (i.e., a quinone methide) was the finding that radioactivity from [14C]CMNQ present in Sarcoma 180 ascites cells was associated with DNA, RNA, and protein for a period of up to 72 hr after exposure to tumor-bearing animals to this agent. "
3.	Ascites 01/01/1979 - "The effect of CMNQ was studied on mitochondria isolated from S-180 ascites tumor cells. " 01/01/1979 - "Effects of the bioreductive alkylating agent 2,3-bis(chloromethyl)-1,4-naphthoquinone on coupled mitochondria isolated from sarcoma 180 ascites cells." 11/01/1976 - "The bioreductive alkylating agent, 2,3-bis(chloromethyl)-1,4-napthoquinone (CMNQ), has been shown to inhibit the growth of Sarcoma 180 ascites cells in vivo. " 11/01/1976 - "Consistent with the concept that reduction of CMNQ to a hydroquinone results in the generation of an alkylating species (i.e., a quinone methide) was the finding that radioactivity from [14C]CMNQ present in Sarcoma 180 ascites cells was associated with DNA, RNA, and protein for a period of up to 72 hr after exposure to tumor-bearing animals to this agent. "

Related Drugs and Biologics

1.	Alkylating Agents
2.	Thymidine Kinase
3.	RNA (Ribonucleic Acid)
4.	Proteins (Proteins, Gene)
5.	Enzymes
6.	DNA (Deoxyribonucleic Acid)
7.	Adenosine (Adenocard)
8.	quinone methide
9.	hydroquinone (Esoterica)