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dimemorfan (AT 17)

RN given refers to parent cpd without isomeric designation; synonym At 17 refers to phosphate[1:1] salt; structure

Also Known As:

AT 17; Astomin; Dastosin; Yamanouchi brand of dimemorfan phosphate; d-3-methyl-N-methylmorphinan; dimemorfan phosphate; dimemorfan phosphate (1:1) salt; dimemorfan, (9alpha,13alpha,14alpha)-isomer; dinemorphan; 3,17-dimethylmorphinan

Networked: 925 relevant articles (22 outcomes, 56 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, Wayseen: 5 articles (12/2013 - 06/2010)
2.	Chen, Chih-Ping: 5 articles (12/2013 - 06/2010)
3.	Su, Jun-Wei: 3 articles (12/2013 - 03/2013)
4.	Chern, Schu-Rern: 3 articles (12/2013 - 06/2010)
5.	Su, Yi-Ning: 3 articles (03/2013 - 06/2010)
6.	Iwanaga, Yoshitaka: 3 articles (11/2012 - 04/2002)
7.	Liao, Jyh-Fei: 3 articles (01/2008 - 03/2003)
8.	Chou, Yueh-Ching: 3 articles (01/2008 - 03/2003)
9.	Levine, Richard J: 3 articles (07/2007 - 03/2004)
10.	Chen, Chieh-Fu: 3 articles (04/2005 - 03/2003)

Related Diseases

1.	Neoplasms (Cancer) 12/01/1991 - "Two patients are disease free at 17 and 21 months, respectively, while the other patient has cytological evidence of malignancy but no other clinically detectable tumor deposits at 27 months." 09/01/2012 - "Based on a robust response, several of our protocols for Tg.rasH2 studies with 15 mice/sex and terminal sacrifice at 17 ± 1 weeks were submitted and accepted by the Carcinogenicity Assessment Committee of the US Food and Drug Administration since we demonstrated close to 100% response for the development of lung and splenic tumors (target organs) in 500 mice/sex. " 11/01/2010 - "Using data from the Agricultural Health Study, we examined the association between body mass index (BMI) and the risk of cancer at 17 sites and the interaction between BMI and pesticide use. " 11/01/2015 - "Pillars4Life is an educational program that teaches coping skills to cancer patients in a virtual group setting; it was recently implemented at 17 hospitals across the USA. " 11/01/2014 - "The Cancer Genome Atlas data were used to examine DNA methylation profiles at 17 CpG sites located in the MSH3 locus. "
2.	Fibrosis (Cirrhosis) 05/01/1997 - "At 17 days there were ulcerated zones to the muscular layer with fibrosis and cellular rests at tracheal path. " 01/01/1990 - "Myocardial biopsy at 17 years of age disclosed a normal endocardium and marked interstitial fibrosis of the myocardium. " 06/01/2015 - "In some animals TGF-β injections were stopped at 17 d when TM fibrosis and IOP were consistently raised and either hrDecorin or PBS IC injections were administered between 21 d and 30 d. " 06/01/2008 - "These treatments resulted in improved fractional shortening (epsilonV1-2: 58+/-2%; olmesartan: 53+/-2%; saline: 41+/-6%) and decreased cardiac parenchymal fibrosis when measured at 17 weeks without lowering blood pressure at any time during the treatment. " 08/01/2014 - "We compared the individual versus combined antifibrotic effects of serelaxin (a recombinant form of human gene-2 relaxin) and the angiotensin-converting enzyme inhibitor enalapril, in preventative (started before injury) and therapeutic (treatment of established fibrosis) strategies, in a mouse model of isoprenaline-induced cardiac injury (at 17 days). "
3.	Pain (Aches) 03/01/2010 - "Eligible patients--those with any diagnosis who reported chronic pain for at least 3 months, who were receiving long-term opioid therapy, and who met criteria for controlled baseline pain--were recruited for a cross-sectional observational study by primary care physicians or community-based oncologists at 17 sites in the United States. " 01/01/2016 - "General anxiety at 13 was unrelated to the presence of chronic pain at 17, but should be considered a risk factor for later pain-related anxiety and disability in a subset of adolescents who develop chronic pain. " 01/01/2016 - "Further analyses revealed that pain-related anxiety at 17 mediated the association between anxiety at 13 and pain-related disability at 17, suggesting that pain-related anxiety should be a target for treatment in adolescents with chronic pain, to reduce the impact of pain in later adolescence. " 01/01/2016 - "For the subsample of adolescents who reported chronic pain, anxiety at 13 was associated with pain-related disability at 17 (n = 393). " 01/01/2016 - "However, anxiety at 13 was significantly associated with pain-related anxiety at 17 (n = 1831). "
4.	Seizures (Seizure) 04/01/2002 - "At 17 months' follow-up, 13 (93%) of 14 patients are seizure free or have significantly improved seizure control. " 04/01/2014 - "An infant was presented at 17 days of age with focal seizures. " 04/01/2005 - "Pre-treatment with dimemorfan (12 or 24 mg kg(-1)) reduced seizures in a dose-dependent manner. " 10/01/2005 - "These patients remain free of seizures at 17 and 15 months, respectively, after treatment (Engle Class IA). " 05/01/1975 - "The present study observed that a 40-dB hearing loss, beginning at 17 days postpartum, requires 2 days before it induces susceptibility to audiogenic seizures. "
5.	Stroke (Strokes) 05/01/2008 - "Adherence rates and achievable benchmarks were determined for 9 PM within a study of patients (n=2294) admitted with acute ischemic stroke at 17 hospitals. " 11/13/2003 - "In a recent study, the documentation of 106 core items in stroke management, as specified in the Swedish National Guidelines for Stroke Management, was evaluated in the records of 70 randomly selected stroke patients treated at 17 hospitals in two county councils between March and May of 2001. " 11/01/2015 - "Based on available data, the frequency of aPL in young patients with CVE can be estimated at 17%, rising up to 22% for aCL in patients with stroke. " 11/01/2012 - "Over the long term, the early group had one ipsilateral stroke at 17 months and the delayed group had two ipsilateral strokes at 3 and 12 months. " 05/22/2012 - "We used generalized ordinal logistic regression to analyze discharge disposition among 12,689 patients with ischemic stroke over a 7-year period at 17 hospitals in an integrated care delivery system. "

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3.	Scopolamine (Hyoscine)
4.	Amyloid (Amyloid Fibrils)
5.	Glutamic Acid (Glutamate)
6.	Isoproterenol (Isoprenaline)
7.	alpha-Fetoproteins (AFP)
8.	1-phenyl-3,3-dimethyltriazene (PDT)
9.	Octreotide (Sandostatin)
10.	Thioguanine (Tioguanine)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Stents
3.	Angioplasty (Angioplasty, Transluminal)
4.	Photochemotherapy (Photodynamic Therapy)
5.	Radiotherapy