4-vinyl-1-cyclohexene dioxide

activates caspase cascades; structure

Also Known As:

1-epoxyethyl-3,4-epoxycyclohexane; 4-vinylcyclohexene diepoxide; vinyl cyclohexane diepoxide; vinyl cyclohexene diepoxide; vinylcyclohexene diepoxide; 3-oxiranyl- 7-oxabicyclo(4.1.0)heptane

Networked: 28 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        Cyclohexenes: 4
        4-vinyl-1-cyclohexene dioxide: 28
  - Acyclic Hydrocarbons
    - Alkenes: 265
      - Vinyl Compounds: 2
        4-vinyl-1-cyclohexene dioxide: 28

Experts

1.	Hoyer, Patricia B: 6 articles (03/2013 - 07/2006)
2.	Marion, Samuel L: 5 articles (03/2013 - 07/2006)
3.	Barton, Jennifer K: 4 articles (03/2013 - 07/2006)
4.	Brooks, Heddwen L: 2 articles (01/2020 - 09/2009)
5.	Ahn, Changhwan: 2 articles (01/2018 - 01/2017)
6.	Jeung, Eui-Bae: 2 articles (01/2018 - 01/2017)
7.	Kang, Hee Young: 2 articles (01/2018 - 01/2017)
8.	Tran, Dinh Nam: 2 articles (01/2018 - 01/2017)
9.	Brewer, Molly A: 2 articles (03/2013 - 07/2012)
10.	Rice, Photini F: 2 articles (03/2013 - 07/2012)

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 05/01/2011 - "In this study, 4-vinylcyclohexene diepoxide (VCD) was used to deplete ovarian follicles and increase the levels of circulating FSH and LH in the tgCAG-LS-TAg mouse model of ovarian cancer. " 03/01/2009 - "The objectives were to determine the time course for ovarian failure in rats caused by 4-vinylcyclohexene diepoxide (VCD) and develop a model for ovarian cancer in which ovarian neoplasms were chemically induced in an animal that was follicle depleted, but retained residual ovarian tissue. " 03/01/2013 - "A mouse model of ovarian cancer was created by dosing with 4-vinylcyclohexene diepoxide, which induces follicular apoptosis (simulating menopause), and 7,12-dimethylbenz[a]anthracene, a known carcinogen. "
2.	Infertility (Sterility) 02/10/2023 - "Maternal exposure to 4-vinylcyclohexene diepoxide during pregnancy induces subfertility and birth defects of offspring in mice." 12/01/2021 - "The aim of the present study was to investigate the effect of Pue on Bcl-2 and Bax protein expression in rats with DOR, associated with infertility within clinical practice, induced by 4-vinylcyclohexene diepoxide (VCD). "
3.	Cardiomegaly (Heart Hypertrophy) 01/01/2019 - "The current study was designed to explore the effects of a modified form of STH on menopausal anxiety, depression and heart hypertrophy and its mechanisms in 4-vinylcyclohexene diepoxide (VCD)-induced menopausal mouse models. "
4.	Primary Ovarian Insufficiency 02/10/2023 - "4-vinylcyclohexene diepoxide (VCD), widely used in industry, is a hazardous compound that can cause premature ovarian failure, but whether maternal VCD exposure affects the health and reproduction of offspring is unknown. " 07/20/2021 - "Effects of low intensity pulsed ultrasound on expression of B-cell lymphoma-2 and BCL2-Associated X in premature ovarian failure mice induced by 4-vinylcyclohexene diepoxide." 01/01/2018 - "Depletion of follicles accelerated by combined exposure to phthalates and 4-vinylcyclohexene diepoxide, leading to premature ovarian failure in rats." 01/01/2018 - "Here, we investigated its role in age-related ovarian dysfunction and 4-vinylcyclohexene diepoxide (VCD)-induced premature ovarian failure using Prx2-deficient mice. " 12/01/2014 - "The effect of American ginseng and its underlying mechanisms in preventing and treating premature ovarian failure (POF) was studied in female Sprague-Dawley rats where POF was induced by ip administration of 4-vinylcyclohexene diepoxide (VCD). "
5.	Neoplasms (Cancer) 07/01/2006 - "Rats are exposed to repeated daily dosing (20 days) with 4-vinylcyclohexene diepoxide (VCD) to cause early ovarian failure (model for postmenopause), and ovaries are directly exposed to 7,12-dimethylbenz(a)anthracene (DMBA) to cause abnormal ovarian proliferation and neoplasia. " 05/01/1989 - "The results of this modified test are compared to those of the linear trend test in proportions, the incidental tumor test, the logistic regression score test, the life table test, and the truncated trend test using information on the incidence of combined alveolar/bronchiolar adenomas or carcinomas in female B6C3F1 mice exposed to vinylcyclohexene diepoxide." 08/01/2012 - "There are three presumable mechanisms involved in the development of POI, namely apoptosis acceleration, follicular maturation blocking and premature follicle activation, through the following studied causes: (i) chromosomal abnormalities or gene mutations: mostly involve X chromosome, such as FMR1 premutation; more and more potentially causal genes have been screened recently; (ii) metabolic disorders such as classic galactosaemia and 17-OH deficiency; (iii) autoimmune mediated ovarian damage: observed alone or with some certain autoimmune disorders and syndromes; but the specificity and sensitivity of antibodies towards ovary are still questionable; (iv) iatrogenic: radiotherapy or chemotherapy used in cancer treatment, as well as pelvic surgery with potential threat to ovaries' blood supply can directly damage ovarian function; (v) virus infection such as HIV and mumps; (vi) toxins and other environmental/lifestyle factors: cigarette smoking, toxins (e.g., 4-vinylcyclohexene diepoxide), and other environmental factors are associated with the development of POI. "

Related Drugs and Biologics

1.	bcl-2-Associated X Protein (bcl 2 Associated X Protein)
2.	anthracene
3.	Proteins (Proteins, Gene)
4.	Estrogens (Estrogen)
5.	Antral
6.	MicroRNAs (MicroRNA)
7.	Amyloid beta-Peptides
8.	9,10-Dimethyl-1,2-benzanthracene
9.	Protein Kinase C
10.	Hormones (Hormone)

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Ovariectomy (Oophorectomy)
4.	Drug Therapy (Chemotherapy)