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substance S

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Also Known As:

4-valeryl-4-(3-chlorophenyl)-1-(3-(4-methylpiperazino)propyl)piperidine.3HCl; 1-(4-(3-chlorophenyl)-1-(3-(4-methyl-1-piperazinyl)propyl)-4- piperidinyl)-1-pentanone, trihydrochloride

Networked: 137 relevant articles (2 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Piperazines: 18
    - substance S: 137

Experts

1.	Seedat, Soraya: 1 article (05/2012)
2.	Saban, Amina: 1 article (05/2012)
3.	Morojele, Neo K: 1 article (05/2012)
4.	Yamada, Masanori: 1 article (02/2012)
5.	Setou, Mitsutoshi: 1 article (02/2012)
6.	Shikata, Nobuaki: 1 article (02/2012)
7.	Hayasaka, Takahiro: 1 article (02/2012)
8.	Takada, Hideho: 1 article (02/2012)
9.	Ushijima, Masaru: 1 article (02/2012)
10.	Matsuura, Masaaki: 1 article (02/2012)

Related Diseases

1.	Intracranial Vasospasm 12/01/1979 - "These results suggest the possibility that the above substance(s) may play a role in prolonged cerebral vasospasm." 08/01/1981 - "The identity of the vasoconstrictor substance(s) in CSF was not established, but serotonin, histamine, norepinephrine, epinephrine, acetylcholine, or angiotensin II were eliminated as prime vasoconstrictor agents inducing cerebral vasospasm. "
2.	Necrosis 01/01/2003 - "Based on animal experiments, it appears that preconditioning consists of a trigger phase with release of signal substance(s), a signal transduction phase where cascade reactions are induced, and an organ effector phase where mediator(s) ensure organ protection against necrosis and apoptosis. " 01/01/1979 - "The results suggested that the kidney extract with high renin content contained substance(s) to produce both medial necrosis and plasma insudation into the media of the arterioles."
3.	Hypertension (High Blood Pressure) 01/01/2012 - "thonningii aqueous leaf extract likely contains antilipidaemic and anticholesterolaemic substance(s), which may be useful in the prophylactic and curative management of lipid peroxidation, high blood pressure, and cardiovascular disorders." 04/01/1978 - "4. The results are consistent with the hypothesis that the renomedullary antihypertensive substance(s) mitigates hypertension by preventing a hypertensive haemodynamic response to sodium/volume overload." 01/01/1990 - "We assessed the role of circulating digitalis-like substance(s) on the blood pressure regulation in patients with essential hypertension, cardiac diseases, diabetes mellitus and renal diseases by measuring digoxin-like immunoreactivity (DLI). " 11/01/1993 - "Since these substances mimic two known inhibitory activities of GA, they have been named 'Glycyrrhetic Acid-Like Factors', abbreviated as 'GALFs' or, more specifically 11 beta-GALF for substance(s) active against 11 beta-OHSD, and 5 beta-GALF for those inhibitory to 5 beta-SR. Administration of glycyrrhetic acid in man leads to cortisol-dependent mineralocorticoid hypertension, owing to impaired inactivation of cortisol by 11 beta-OHSD, and may be associated with increased sensitivity to mineralocorticoids owing to impaired 5 beta-SR. In this preliminary report, the results are described of a study on the presence of GALF factors in urines collected from patients with congestive heart failure (CHF) and mild essential hypertension. "
4.	Substance-Related Disorders (Drug Abuse) 03/01/2011 - "Our purpose is to monitor HCV infection among drug users treated in a Drug Addiction Centre (Ser.T) in Naples and to gain a better understanding of that relationship with the abused substance(s). " 05/01/2007 - "This study examined the frequency and pattern of cognitive impairment in individuals entering substance use disorder treatment and additionally examined the relation between pattern of cognitive impairment and type of substance(s) used: alcohol (n = 116), cocaine (n = 49), alcohol/cocaine (n = 76), and alcohol/multiple substance (n = 54). "
5.	Glucagonoma 01/01/1995 - "In summary, the glucagonomas provide an interesting tool with which to study the nature of severe anorexia as well as adipsia, and the identification of the active substance(s) may provide novel therapeutics for the treatment of obesity-related disorders such as NIDDM." 11/01/1993 - "We conclude 1) that glucagonomas and insulinomas can be derived from a common clonal origin of pluripotent MSL cells, thus supporting the existence of a cell lineage relationship between islet alpha- and beta-cell during ontogeny; and 2) that our glucagonomas release an anorexigenic substance(s) of unknown nature that causes a severe weight loss comparable to that reported in animals carrying tumor necrosis factor-producing experimental tumors."

Related Drugs and Biologics

1.	Epinephrine (Adrenaline)
2.	Vasoconstrictor Agents
3.	Serotonin (5 Hydroxytryptamine)
4.	Norepinephrine (Noradrenaline)
5.	Histamine (Histamine Dihydrochloride)
6.	Angiotensin II
7.	Acetylcholine (Acetylcholine Chloride)
8.	Hydrocortisone (Cortisol)
9.	Digoxin (Digitek)
10.	Glucocorticoid Receptors (Glucocorticoid Receptor)

Related Therapies and Procedures

1.	Therapeutics
2.	Homologous Transplantation (Allograft)
3.	Renal Dialysis (Hemodialysis)
4.	Drug Therapy (Chemotherapy)
5.	Adrenalectomy