pyriminil

RN given refers to parent cpd; structure

Also Known As:

1-(3-pyridylmethyl)-3-(4-nitrophenyl)urea; N-(3-pyridylmethyl)-N'-(p-nitrophenyl)urea; RH 787; Vacor; pyriminil malonate (1:1); pyriminil monohydrobromide; pyriminil monohydrochloride; pyriminil monotosylate; pyriminil oxalate (1:1); pyriminil tartrate (1:1); pyriminyl; N-(4-nitrophenyl)-N'-(3- pyridinylmethyl)urea

Networked: 33 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Phenylurea Compounds: 1
      - pyriminil: 33
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenylurea Compounds: 1
        pyriminil: 33

Experts

1.	Ziegler, Mathias: 2 articles (01/2021 - 01/2018)
2.	Aagaard Poulsen, Kristian: 1 article (01/2022)
3.	Bohm, Aske Mathias: 1 article (01/2022)
4.	Borly, Lars: 1 article (01/2022)
5.	Bremholm Ellebæk, Mark: 1 article (01/2022)
6.	Buyukuslu, Musa: 1 article (01/2022)
7.	Grant Sølling, Christoffer: 1 article (01/2022)
8.	Kobborg, Martin: 1 article (01/2022)
9.	Lund Lomholt, Marianne: 1 article (01/2022)
10.	Luxhøi, Jan: 1 article (01/2022)

Related Diseases

1.	Diabetes Mellitus 04/01/1989 - "The pathomechanism of Vacor-induced diabetes mellitus has not been clarified yet. " 07/01/1986 - "Muscle capillary basement membrane width in patients with vacor-induced diabetes mellitus." 10/01/1985 - "With this procedure, it was possible to obtain an objective evaluation of the significance of capillary basement membrane thickening in Vacor diabetes mellitus. " 10/01/1985 - "The effect of Vacor diabetes mellitus on the quadriceps muscle capillary basement membrane thickness has been examined by the electron microscopic method. " 02/01/1979 - "Diabetes mellitus and neuropathy following Vacor ingestion in man."
2.	Poisoning 07/01/1981 - "Poisoning with N-3-pyridylmethyl-N'-p-nitrophenylurea (Vacor). " 08/01/1980 - "There is a high possibility of poisoning cats in field deratization campaigns with Vacor. " 04/01/1980 - "Postmortem findings for a Vacor poisoning case." 06/01/1978 - "Symptoms of pyriminyl poisoning appear from 1 to 4 h after feeding starts, giving individual animals time to consume from 2 to over 30 LD 50 doses of 0.5% pyriminyl before feeding stops. " 01/01/1977 - "Vacor poisoning in the cat."
3.	Orthostatic Hypotension (Postural Hypotension) 10/01/1981 - "Full recovery from severe orthostatic hypotension after vacor rodenticide ingestion." 10/01/1981 - "A 20-year-old woman developed severe orthostatic hypotension after attempting suicide by ingesting the rodenticide, Vacor. " 10/01/1981 - "Ocular ergotamine tartrate toxicity during treatment of Vacor-induced orthostatic hypotension." 03/01/1978 - "Seven days after ingestion of Vacor, the patient presented in diabetic ketoacidosis complicated by postural hypotension and adynamic ileus. " 01/01/1981 - "Diabetes mellitus and orthostatic hypotension resulting from ingestion of Vacor rat poison: endocrine and autonomic function studies."
4.	Peripheral Nervous System Diseases (PNS Diseases) 02/01/1998 - "The ultrastructural studies of the neuromuscular junction were performed to clarify the anatomic site of the Vacor-induced peripheral neuropathy in male Wistar rats. " 02/01/1998 - "These results suggest that degenerative changes in axon terminal at neuromuscular junction may contribute to the peripheral neuropathy developed in the early phase of Vacor poisoning." 02/01/1998 - "Rodenticide Vacor causes a severe peripheral neuropathy in humans. " 04/01/1981 - "Diabetes mellitus associated with autonomic and peripheral neuropathy after Vacor rodenticide poisoning: a review." 02/01/1980 - "A recently introduced rodenticide containing N-3-pyridylmethyl N'-p-nitrophenyl urea (PNU), Vacor, was accidently ingested by a 25-month-old child, resulting in acute vomiting, lethargy, seizures, and hypoglycemia, as well as chronic evidence of autonomic and peripheral neuropathy and glucose intolerance. "
5.	Body Weight (Weight, Body) 04/06/1988 - "In this study, oral administration of 100 mg Vacor/kg of body weight was used in Wistar male rats. " 02/01/1998 - "After oral administration of a single dose of Vacor, 80 mg/kg of body weight, to the experimental animals, neuromuscular junctions within the interosseous muscles of the hind foot were observed in time. "

Related Drugs and Biologics

1.	Poisons
2.	Rodenticides
3.	Urea (Carbamide)
4.	Insulin (Novolin)
5.	Streptozocin (Streptozotocin)
6.	Enzymes
7.	Reactive Oxygen Species (Oxygen Radicals)
8.	Phosphotransferases (Kinase)
9.	Pentamidine (NebuPent)
10.	Oxidoreductases (Dehydrogenase)

Related Therapies and Procedures

1.	Oral Administration
2.	Negative-Pressure Wound Therapy