ruscogenin

07/01/2014 - "The protective effects of ruscogenin on nonalcoholic steatohepatitis in hamsters fed a high-fat diet were investigated. "
01/01/2014 - "Ruscogenin ameliorates experimental nonalcoholic steatohepatitis via suppressing lipogenesis and inflammatory pathway."
07/01/2014 - "Ruscogenin protects against high-fat diet-induced nonalcoholic steatohepatitis in hamsters."
01/01/2014 - "The aim of the study was to investigate the protective effects of ruscogenin, a major steroid sapogenin in Ophiopogon japonicus, on experimental models of nonalcoholic steatohepatitis. "

01/01/2022 - "NLRP3 overexpression reversed the repressive effect of Ruscogenin on TNF-α-induced inflammation and apoptosis of acinar cells. "
01/01/2022 - "Ruscogenin inhibited acinar cell apoptosis in NOD/ShiLtJ mice and reversed TNF-α-induced apoptosis and inflammation of acinar cells. "
01/01/2022 - "Ruscogenin ameliorated the SFR and submandibular gland inflammation of NOD/ShiLtJ mice. "
01/01/2017 - "DT-13(25(R,S)-ruscogenin-1-O-[β-d-glucopyranosyl-(1→2)][β-d-xylopyranosyl-(1→3)]-β-d-fucopyranoside) has been identified as an important factor in TNF-α-induced vascular inflammation. "
03/26/2014 - "Our data demonstrated that ruscogenin suppressed the inflammation and ameliorated the structural and functional abnormalities of the diabetic kidney in rats might be associated with inhibition of NF-κB mediated inflammatory genes expression."

01/01/2022 - "The aim of this study was to explore the role of ruscogenin in airway inflammation and apoptosis in asthma. "
01/01/2022 - "Protective effects and mechanism of action of ruscogenin in a mouse model of ovalbumin-induced asthma."
01/01/2022 - "Ruscogenin is a natural product exhibiting anti-inflammatory, antioxidant, and anti-apoptotic effects; however, its effectiveness for asthma management has not yet been reported. "

01/01/2022 - "Ruscogenin (RUS) has shown considerable efficacy in treating ED and sepsis. "
01/01/2012 - "These findings confirmed that ruscogenin significantly attenuate LPS-induced acute lung injury via inhibiting expressions of TF and iNOS and NF-κB p65 activation, indicating it as a potential therapeutic agent for ALI or sepsis."
06/08/2021 - "Ruscogenin (RUS) has been found to exhibit anti-inflammation property and rescue lipopolysaccharide-induced ALI, but little is known about its role in sepsis-triggered ALI. "
06/08/2021 - "Ruscogenin attenuates sepsis-induced acute lung injury and pulmonary endothelial barrier dysfunction via TLR4/Src/p120-catenin/VE-cadherin signalling pathway."

01/01/2022 - "Ruscogenin ameliorates acute kidney injury via suppressing ferroptosis in kidney tissues through modulation of the Rev-erbα/β-SLC7A11/HO-1 pathway."
01/01/2022 - "To investigate the pharmacodynamic effects of ruscogenin on acute kidney injury and the Rev-erbα/β regulation of ferroptosis intervention mechanism. "
01/01/2022 - "Ruscogenin (1 mg/kg) significantly reduced the index of folic acid-induced acute kidney injury and alleviated acute kidney injury. "