Plasma-lyte 148

irrigating solution used in perfusion of corneal endothelium; contains sodium, potassium & magnesium chlorides, sodium acetate & sodium gluconate; also used as cardioplegic solution

Also Known As:

Networked: 33 relevant articles (3 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bellomo, Rinaldo: 7 articles (10/2017 - 04/2012)
2.	McArthur, Colin J: 3 articles (05/2020 - 12/2014)
3.	Weinberg, Laurence: 3 articles (05/2020 - 03/2015)
4.	Bailey, Michael J: 3 articles (10/2017 - 12/2014)
5.	Beasley, Richard W: 3 articles (10/2017 - 12/2014)
6.	Mackle, Diane M: 3 articles (10/2017 - 12/2014)
7.	Reddy, Sumeet K: 3 articles (10/2017 - 12/2014)
8.	Young, Paul J: 3 articles (10/2017 - 12/2014)
9.	Dayal, Devi: 2 articles (11/2021 - 01/2020)
10.	Jayashree, Muralidharan: 2 articles (11/2021 - 01/2020)

Related Diseases

1.	Critical Illness (Critically Ill) 11/04/2016 - "We retrieved 104 articles relevant to the choice of Plasma-Lyte 148 for fluid intervention in critical illness, surgery and perioperative medicine. " 01/01/2018 - "BCs, especially the Plasma-Lyte, are presumably the best choice for most critically ill patients who need fluid resuscitation. " 09/01/2016 - "A multicentre randomised controlled pilot study of fluid resuscitation with saline or Plasma-Lyte 148 in critically ill patients." 07/03/2021 - "Balanced solutions, such as Plasma-Lyte 148 and Compound Sodium Lactate, represent potential alternatives but the evidence on optimal fluid choices in critically ill children remains scarce. " 10/01/2020 - "BaSICS is a multicenter factorial randomized controlled trial that will assess the effects of Plasma-Lyte 148 versus 0.9% saline as the fluid of choice in critically ill patients, as well as the effects of a slow (333mL/h) versus rapid (999mL/h) infusion speed during fluid challenges, on important patient outcomes. "
2.	Acidosis 10/31/2023 - "Five of 16 secondary outcomes differed with Plasma-Lyte-148: hypernatremia was significantly more frequent (odds ratio 3·5 (1·1 - 10·8)), significantly fewer changes to fluid prescriptions were made (rate ratio 0·52 (0·40-0·67)), and significantly fewer participants experienced hyperchloremia (odds ratio 0·17 (0·07 - 0·40)), acidosis (odds ratio 0·09 (0·04 - 0·22)) and hypomagnesemia (odds ratio 0·21 (0·08 - 0·50)). " 04/01/2022 - "Compared with the half saline group, the Plasma-lyte group showed less metabolic acidosis and hyponatremia during surgery. " 11/01/2008 - "With the trial fluid, metabolic acid-base status was normal following bypass initiation (standard base excess 0.1 (1.3) mEq/l, mean, SD), whereas Plasma-Lyte 148 produced a slight metabolic acidosis (standard base excess -2.2 (2.1) mEq/l). " 12/01/2017 - "Patients in the Plasma-Lyte group were less likely to require emergency postoperative dialysis than those receiving 0.9% saline [odds ratio (OR) 0.15 (95% confidence interval 0.03-0.48), P = 0.004], and these patients had more favourable biochemical parameters with less hyperkalaemia, less acidosis and better diuresis. " 05/01/2023 - "Plasma-lyte may resolve diabetic ketoacidosis faster, while prolonged NS use can lead to metabolic acidosis, acute kidney injury, and cerebral edema. "
3.	Sepsis (Septicemia) 04/01/2014 - "Volume resuscitation with Plasma-Lyte resulted in less acidosis and less kidney injury and improved short-term survival when compared with 0.9% saline in this experimental animal model of sepsis." 04/01/2014 - "We induced sepsis by cecal ligation and puncture and randomized animals to receive fluid resuscitation with either 0.9% saline or Plasma-Lyte solution for 4 hours after 18 hours of cecal ligation and puncture (10 mL/kg in the first hour and 5 mL/kg in the next 3 hr). "
4.	Septic Shock (Toxic Shock Syndrome) 01/01/2020 - "Plasma-Lyte with lower chloride concentration than saline has been shown to be associated with reduced incidence of AKI in adults with septic shock. "
5.	Diabetic Ketoacidosis (Ketoacidosis, Diabetic) 01/01/2020 - "0.9% saline versus Plasma-Lyte as initial fluid in children with diabetic ketoacidosis (SPinK trial): a double-blind randomized controlled trial." 04/01/2012 - "The purpose of the study was to determine the effects of Plasma-Lyte 148 (PL) vs 0.9% saline (NS) fluid resuscitation in diabetic ketoacidosis (DKA). " 04/01/2012 - "Plasma-Lyte 148 vs 0.9% saline for fluid resuscitation in diabetic ketoacidosis." 05/01/2023 - "Plasma-lyte may resolve diabetic ketoacidosis faster, while prolonged NS use can lead to metabolic acidosis, acute kidney injury, and cerebral edema. "

Related Drugs and Biologics

1.	Saline Solution
2.	Crystalloid Solutions
3.	Chlorides
4.	Solutions
5.	Sodium Chloride
6.	Acids
7.	Ringer's Lactate
8.	boldenone undecylenate (Equipoise)
9.	Sodium Lactate
10.	Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1.	Resuscitation
2.	Fluid Therapy (Oral Rehydration Therapy)
3.	Kidney Transplantation
4.	Punctures
5.	Ligation