phosphocyclocreatine

structure

Also Known As:

1-carboxymethyl-2-imino-3-phosphonoimidazolidine; 1-carboxymethyl-2-iminophosphoimidazolidine; N-phosphorylcyclocreatine; cyclocreatine phosphate; 1-imidazolidineacetic acid, 2-imino-3-phosphono-

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Creatine: 3124
    - Phosphocreatine: 1826
      - phosphocyclocreatine: 10
  - Phosphoamino Acids: 1
    - Phosphocreatine: 1826
      - phosphocyclocreatine: 10
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Imidazolidines: 39
        phosphocyclocreatine: 10

Experts

1.	Elgebaly, Salwa A: 2 articles (03/2021 - 09/2019)
2.	Kreutzer, Donald L: 2 articles (03/2021 - 09/2019)
3.	Todd, Robert: 2 articles (03/2021 - 09/2019)
4.	Ahmed, Lamiaa A: 1 article (03/2021)
5.	Arafa, Reem K: 1 article (03/2021)
6.	Christenson, Robert: 1 article (03/2021)
7.	El Sayed, Nesrine S: 1 article (03/2021)
8.	El-Khazragy, Nashwa: 1 article (03/2021)
9.	Mohamed, Ahmed F: 1 article (03/2021)
10.	Rabie, Mostafa A: 1 article (03/2021)

Related Diseases

1.	Ischemia 03/27/1994 - "The present study determined whether the administration of cyclocreatine phosphate (CCrP) prior to ischemia can enhance the recovery of rat hearts hypothermically preserved for a prolonged period. " 03/16/2023 - "Cyclocreatine phosphate (CCrP) was shown to preserve myocardial ATP during ischemia and maintain cardiac function in various animal models of ischemia/reperfusion. " 03/30/2021 - "Cyclocreatine phosphate (CCrP) is a potent bioenergetic cardioprotective compound known to preserve high levels of cellular adenosine triphosphate during ischemia. " 05/01/1980 - "Utilization of cyclocreatine phosphate, and analogue of creatine phosphate, by mouse brain during ischemia and its sparing action on brain energy reserves." 01/01/1992 - "One factor in the mechanism of protection may be the prolonged maintenance of phosphagen due to the higher equilibrium concentration of phosphocyclocreatine which in turn provides substrate for continued synthesis of ATP during and after ischemia, thus defining Cy as a bioenergetic protective agent. "
2.	Heart Failure 03/16/2023 - "Cyclocreatine Phosphate: A Novel Bioenergetic/Anti-Inflammatory Drug That Resuscitates Poorly Functioning Hearts and Protects against Development of Heart Failure." 03/30/2021 - "Nourin-Associated miRNAs: Novel Inflammatory Monitoring Markers for Cyclocreatine Phosphate Therapy in Heart Failure."
3.	Neoplasms (Cancer) 01/01/1996 - "The synthetic phosphagen cyclocreatine phosphate inhibits the growth of a broad spectrum of solid tumors."
4.	Glioma (Gliomas) 01/01/1996 - "An intrinsic 31P-nuclear magnetic resonance (31P-NMR) signal of phosphocreatine, as well as accumulation of phosphocyclocreatine (PCY) after addition of CY, was observed for C6 glioma but not for the OC238 cells. "
5.	Hypoxia (Hypoxemia) 11/01/2023 - "This can be achieved either by subtle targeted reduction in UCP-1 expression using innovative proteolysis activating chimeric molecules (PROTACs) or by supplementation with cyclocreatine phosphate, which augments the mitochondrial futile creatine cycling and thus decreases UCP1 activity, enhances the efficiency of oxygen use, and reduces hypoxia. "

Related Drugs and Biologics

1.	Adenosine Triphosphate (ATP)
2.	Phosphocreatine (Neoton)
3.	MicroRNAs (MicroRNA)
4.	Protective Agents
5.	Adrenergic Agents (Adrenergic Drugs)
6.	Salts
7.	Oxygen (Dioxygen)
8.	Creatine
9.	Proteolysis Targeting Chimera
10.	cyclocreatine

Related Therapies and Procedures

1.	Therapeutics