HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

diisopropanolnitrosamine

Subscribe to New Research on diisopropanolnitrosamine

experimental carcinogen; structure

Also Known As:

2,2'-BHP; 2,2'-dihydroxy-di-n-propylnitrosamine; BHP cpd; DHPN; N-bis(2-hydroxypropyl)nitrosamine; N-nitroso-bis(2-hydroxypropyl)amine; N-nitrosobis(2-hydroxypropyl)amine; nitroso-di-isopropanolamine; 2-propanol, 1,1'-(nitrosoimino)bis-

Networked: 157 relevant articles (2 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Nitroso Compounds: 319
  - Nitrosamines: 522
    - diisopropanolnitrosamine: 157

Experts

1.	Tsujiuchi, Toshifumi: 15 articles (03/2014 - 10/2002)
2.	Hirose, Masao: 15 articles (06/2012 - 04/2002)
3.	Imai, Toshio: 9 articles (06/2012 - 03/2004)
4.	Konishi, Y: 9 articles (12/2001 - 02/2000)
5.	Sasaki, Y: 9 articles (12/2001 - 02/2000)
6.	Tsutsumi, M: 9 articles (12/2001 - 02/2000)
7.	Tsujiuchi, T: 9 articles (12/2001 - 02/2000)
8.	Hasumura, Mai: 8 articles (06/2012 - 03/2004)
9.	Honoki, Kanya: 8 articles (01/2010 - 02/2006)
10.	Shimizu, Kyoko: 7 articles (02/2008 - 02/2006)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2004 - "Our results suggest that rasH2 mice are highly susceptible to DHPN, the target organs including the forestomach, salivary gland and urethra, which have not been found to develop tumors in previous long-term carcinogenicity studies of DHPN in rats and mice." 03/01/2003 - "The present study was designed to investigate the effects of fermented miso in the diet on the development of lung tumors initiated by diisopropanolnitrosamine (BHP) in male Slc:Wistar rats. " 09/01/2000 - "In the two-stage carcinogenicity study, thyroidal weights and the incidence of thyroid tumors derived from the follicular epithelium were significantly increased in the DHPN+KI as compared with the DHPN alone group. " 09/25/1995 - "In the present study, we investigated mutational activation of the Ki-ras gene in eight thyroid, five kidney (four mesenchymal and one transitional cell lesion) and two lung tumors induced with DHPN. " 06/01/2010 - "N-nitrosobis(2-hydroxypropyl)amine (BHP) is a well-known carcinogen and induces tumors in various tissues. "
2.	Adenoma (Adenomas) 12/01/1987 - "The incidence of thyroid adenomas at the end of week 20 of the experiment was 100% (20/20) in rats treated with DHPN followed by KClO4, 85% (17/20) in rats given DHPN followed by KI, 95% (19/20) in rats given DHPN followed by PTU, and 5% (1/20) in rats given DHPN alone. " 09/01/1985 - "Upon feeding the DHPN-treated rats with basal diet containing 20, 100, 500, and 2500 ppm of PB, the incidences of follicular adenoma were, respectively, 8, 45, 70, and 66% in male rats and 12, 17, 50, and 58% in female rats. " 05/01/1984 - "Papillary adenoma was observed in one rat treated with DHPN followed by PTU. " 05/01/1984 - "The incidences of follicular adenoma at the end of week 20 of the experiment were 100% (21/21) in rats treated with DHPN followed by PTU, and 19% (4/21) in rats given DHPN alone. " 10/01/1980 - "Between 65 and 102 weeks, 8 of 9 males given DHPN (89%) and 11 of 14 females given DHPN (78%) developed pulmonary adenomas. "
3.	Hyperplasia 03/01/2014 - "In the proliferative lesions including hyperplasia induced by DHPN, strong positive staining for napsin A was observed in the walls of the alveoli. " 03/01/2014 - "Differences between hyperplasias induced by DHPN and by NNK were here examined immunohistochemically. " 05/01/2001 - "In the groups without DHPN initiation, only focal follicular cell hyperplasia was observed in 1/9 rats in the 2%KA-alone group. " 05/01/2001 - "Histopathologically, the incidences of focal thyroid follicular cell hyperplasias in the DHPN-initiated groups treated with 0.125%, 0.5% and 2%KA at week 20 were 5/10, 10/10 and 8/8 rats, respectively. " 12/01/1988 - "H3NTA produced only a slight increase in the incidence of preneoplastic urinary bladder lesions (PN-hyperplasia) in rats initiated by DHPN, and this was not statistically significant. "
4.	Adenocarcinoma 03/01/2010 - "Recently, frequent mutations of the LPA receptor-1 (LPA1) gene were detected in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine (BHP). " 01/01/2010 - "To better understand the involvement of LKB1 gene alterations during lung carcinogenesis, we investigated the LKB1 gene mutations and expressions in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) in rats. " 01/01/2010 - "Alterations of the LKB1 gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats." 10/01/2007 - "To assess the involvement of the Dal-1 gene in rat lung carcinogenesis, we investigated the expression of Dal1 and its methylation status in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine (BHP). " 10/01/2007 - "Hypermethylation of the Dal-1 gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats."
5.	Carcinoma (Carcinomatosis) 07/01/1983 - "Study on the histogenesis of pancreatic carcinoma induced in hamsters by diisopropanolnitrosamine." 09/01/1978 - "[Studies of DHPN induced pancreatic carcinoma with emphasis on pancreatography (author's transl)]." 07/01/2000 - "These results suggest that Bowman's glands are the target of DMA, giving rise to nasal carcinomas after DHPN-initiation." 08/03/1999 - "Histopathological assessment showed the incidence of carcinomas in the DHPN+DMA group (33%) to be significantly elevated as compared with that for the DHPN-alone group (5%). " 09/25/1995 - "These results suggest that Ki-ras mutations are frequent events during the development of DHPN-induced carcinomas in these organs. "

Related Drugs and Biologics

1.	Testosterone (Sustanon)
2.	Estradiol (Estrace)
3.	diisopropanolnitrosamine
4.	Phenobarbital (Luminal)
5.	Methylnitrosourea (N-Methyl-N-nitrosourea)
6.	DNA (Deoxyribonucleic Acid)
7.	Diethylnitrosamine (N-Nitrosodiethylamine)
8.	beta Catenin
9.	Cadherins (E-Cadherin)
10.	Curcumin

Related Therapies and Procedures

1.	Ovariectomy (Oophorectomy)
2.	Subcutaneous Injections
3.	Injections
4.	Aftercare (After-Treatment)
5.	Thyroidectomy