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6-hydroxymelatonin

Also Known As:

6-oxymelatonin; N-(2(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl)acetamide

Networked: 24 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Tryptamines: 1679
        Melatonin: 11033
        6-hydroxymelatonin: 24
Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Melatonin: 11033
    - 6-hydroxymelatonin: 24

Experts

1.	Stepień, Agnieszka: 2 articles (05/2009 - 05/2007)
2.	Gu, Wenbo: 1 article (12/2021)
3.	Guo, Xiaoyu: 1 article (12/2021)
4.	Han, Tianshu: 1 article (12/2021)
5.	Jiang, Wenbo: 1 article (12/2021)
6.	Jiang, Xitao: 1 article (12/2021)
7.	Li, Ying: 1 article (12/2021)
8.	Li, Yunong: 1 article (12/2021)
9.	Lu, Huimin: 1 article (12/2021)
10.	Lu, Jiang: 1 article (12/2021)

Related Diseases

1.	Sleep Initiation and Maintenance Disorders (Insomnia) 01/01/2015 - "As most patients reported chronic insomnia and fatigue, we determined the 24 h urine 6-hydroxymelatonin sulfate (6-OHMS)/creatinin ratio and found it was decreased (<0.8) in all investigated cases. " 01/01/2022 - "This drug has been confirmed to be effective in the treatment of insomnia by regulating the content of serotonin, 6-hydroxymelatonin, N-acetylserotonin, and N-methyltryptamine to a stable and normal level in tryptophan metabolism."
2.	Sleep Wake Disorders 01/01/2005 - "Urinary 6-hydroxymelatonin sulfate excretion in intellectually disabled subjects with sleep disorders and multiple medications: validation of measurements in urine extracted from diapers." 01/01/2005 - "The aim of this study was to examine the applicability of urinary 6-hydroxymelatonin sulfate (MT6s) measurements in the evaluation of melatonin secretion in intellectually disabled patients with sleep disorders. "
3.	Alzheimer Disease (Alzheimer's Disease) 08/01/2002 - "This study assessed the relationship between occupational magnetic field exposure, the urinary melatonin metabolite 6-hydroxymelatonin sulfate (6-OHMS), and concentrations of blood-borne soluble amyloid beta (A beta), a protein associated with the hallmark lesions of Alzheimer's disease (AD). "
4.	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 06/01/2010 - "Evaluation of urinary 6-hydroxymelatonin sulphate excretion in women at different age with irritable bowel syndrome." 05/01/2009 - "To evaluate melatonin (MEL) secretion and its metabolism to 6-hydroxymelatonin sulfate (6HMS) in patients with irritable bowel syndrome (IBS). "
5.	Sepsis (Septicemia) 05/01/2014 - "In addition, we developed an ex vivo whole blood model under conditions mimicking sepsis to determine the bioactivity of melatonin and the major metabolite 6-hydroxymelatonin at relevant concentrations. " 05/01/2014 - "Both melatonin and 6-hydroxymelatonin had beneficial effects on sepsis-induced mitochondrial dysfunction, oxidative stress, and cytokine responses at concentrations similar to those achieved in vivo." 08/01/2011 - "Human endothelial cells were treated with lipopolysaccharide (LPS) plus peptidoglycan G (PepG) to simulate sepsis, in the presence of melatonin, 6-hydroxymelatonin, tryptamine, or indole-3-carboxylic acid. "

Related Drugs and Biologics

1.	N-acetylserotonin
2.	Tryptophan (L-Tryptophan)
3.	Serotonin (5 Hydroxytryptamine)
4.	N-methyltryptamine
5.	Melatonin
6.	Sulfates (Sulfates, Inorganic)
7.	Amyloid beta-Peptides
8.	Proteins (Proteins, Gene)
9.	Cytokines
10.	1-Naphthylisothiocyanate (1 Naphthylisothiocyanate)

Related Therapies and Procedures

1.	Sympathectomy (Sympathectomies)