equinatoxin

basic protein from Actinia equina (Coelenterata); has 3 isolates with MW 19,000 that differ only slightly in amino acid composition and have a high tryptophan content

Also Known As:

Networked: 13 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Suput, D: 3 articles (09/2001 - 01/2000)
2.	Anderluh, Gregor: 2 articles (01/2012 - 04/2010)
3.	Moura-Neto, Vivaldo: 2 articles (01/2012 - 04/2010)
4.	Soletti, Rossana C: 2 articles (01/2012 - 04/2010)
5.	Bunc, M: 2 articles (09/2001 - 01/2000)
6.	Frangez, R: 2 articles (09/2001 - 11/2000)
7.	Gnangnon, Bénédicte: 1 article (06/2020)
8.	Peucelle, Véronique: 1 article (06/2020)
9.	Pierrot, Christine: 1 article (06/2020)
10.	Hwang, Jung Shan: 1 article (12/2019)

Related Diseases

1.	Pulmonary Edema 01/01/1984 - "As it is a potent inducer of pulmonary edema, equinatoxin may become an important probe to study fluid regulation in the lung."
2.	Hemolysis 12/01/2019 - "Hydra actinoporin-like toxin 1 (HALT-1) was previously shown to cause cytolysis and haemolysis in a number of human cells and has similar functional properties to the actinoporins equinatoxin and sticholysin. " 09/01/2001 - "This suggests that equinatoxin III induced haemolysis is not the major mechanism of equinatoxin III lethality. " 01/01/1981 - "Kinetics of hemolysis induced by equinatoxin, a cytolytic toxin from the sea anemone Actinia equina. " 09/01/2001 - "As equinatoxin II is less lythic, but more toxic, than equinatoxin III (its LD50 in mice=35 microg/kg), it may be assumed that haemolysis with a consequent rise in plasma potassium level is not the major factor in the lethality of equinatoxins. "
3.	Shock 01/01/2000 - "Death after i.v. administration of equinatoxin II (EqT II) has been attributed to the circulatory failure resulting from cardiotoxic effects. " 01/01/2000 - "Death after i.v. administration of equinatoxin II (EqT II) has been attributed to the circulatory failure resulting from cardiotoxic effects. "
4.	Glioblastoma (Glioblastoma Multiforme) 04/01/2010 - "To investigate how cytolysins are cytotoxic to resistant cancer cells, proliferation and cell death were evaluated on U87 glioblastoma cells treated with toxin Bc2 or equinatoxin-II (EqTx-II). " 01/01/2012 - "Equinatoxin II potentiates temozolomide- and etoposide-induced glioblastoma cell death."
5.	Cardiotoxicity 01/01/1999 - "Equinatoxin II is a lethal basic protein isolated from the sea anemone Actinia equina (L.) with LD50 in mice 35 microg/kg. The putative cause of death is cardiorespiratory arrest, but the mechanism of cardiotoxicity is poorly understood. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	equinatoxin
3.	Streptolysins
4.	Potassium
5.	Etoposide (VP 16)
6.	Cytotoxins (Cytolysins)
7.	Temozolomide (Temodar)
8.	fragaceatoxin C