clobazam (HR 376)

01/01/2008 - "Clobazam as an add-on treatment may reduce seizure frequency and may be most effective in partial onset seizures. "
03/01/2010 - "Clobazam was effective against all seizure types with complete seizure control seen in 60.2% patients. "
11/01/2008 - "Clobazam (CLB) has proven efficacy against multiple seizure types. "
01/01/2013 - "We describe our experience using clobazam, examining efficacy for individual seizure types and analyzing for factors contributing to initial and sustained response. "
02/01/2005 - "Sixteen (20.5%) patients were seizure-free, 20 (25.5%) had more than 75% improvement in seizure control, eight (10%) had more than 50% and 20 (26%) were non responders to clobazam. "

06/01/2003 - "The efficacy of Clobazam coupled with the lack of significant side effects noted in our study makes it merit consideration as monotherapy in adult patients with epilepsy."
07/01/2015 - "Clobazam: A Safe, Efficacious, and Newly Rediscovered Therapeutic for Epilepsy."
09/01/2014 - "Intermittent clobazam prophylaxis in hot water epilepsy is safe and effective: a prospective study."
02/01/2012 - "Clobazam offers a new treatment option for patients with refractory epilepsy. "
11/01/2008 - "Efficacy of clobazam as add-on therapy for refractory epilepsy: experience at a US epilepsy center."

11/01/1999 - "Ten of the 20 children with severe myoclonic epilepsy in infancy also responded with clobazam (CLB) as comedication. "
01/01/2007 - "Whereas the studies in adult patients were disappointing, the trials conducted in pediatric populations demonstrated a specific efficacy of STP in severe myoclonic epilepsy in infancy, Dravet syndrome, when combined with valproate and clobazam. "
07/01/2005 - "Although the studies in adult patients were disappointing, the trials conducted in paediatric populations demonstrated a specific efficacy of STP in a severe form of early childhood epilepsy, Dravet syndrome (severe myoclonic epilepsy in infancy), when combined with valproate and clobazam. "
11/01/2002 - "To describe the long term efficacy and tolerance of stiripentol associated with valproate and clobazam in an exhaustive cohort of patients with severe myoclonic epilepsy of infancy (Dravet's syndrome), in which short term efficacy of such a treatment has recently been demonstrated in a placebo-controlled trial. "
04/01/2006 - "A metabolic interaction between stiripentol (STP), an anticonvulsant agent that inhibits the activity of several cytochromes P450 (P450s), and clobazam (CLB), a 1,5-benzodiazepine, used in association with STP in severe myoclonic epilepsy in infancy was observed in vivo. "

01/01/2013 - "Clobazam (CLB) is a 1,5-benzodiazepine, which is known to be effective for treating refractory partial epilepsy. "
09/01/2006 - "The objective of this study was to evaluate the safety and efficacy of clobazam in children with refractory focal epilepsy. "
04/01/2001 - "Efficacy of clobazam as add-on therapy in patients with refractory partial epilepsy."
09/01/2006 - "Effectiveness of clobazam as add-on therapy in children with refractory focal epilepsy."
05/01/2006 - "Clobazam has been used successfully in adults and children with partial epilepsy. "

08/01/2010 - "The administration of clobazam resulted in the marked improvement of EEG findings and transient disappearance of spasms. "
07/01/2014 - "Immunoglobulin and clobazam administered at 11 months were effective for the spasms, but profound psychomotor retardation remained. "
02/15/2009 - "Epileptic spasms and tonic seizures were prominent in group 4 and were refractory to medical treatment, except that zonisamide, clobazam, and a ketogenic diet were partially or transiently effective. "