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7,8- dichloro- 1,2,3,4- tetrahydroisoquinoline

potent reversible inhibitor of phenylethanolamine N-methyltransferase; structure

Also Known As:

DCTQ; SK&F 64139; SK&F-64139; SKF 64139

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - Tetrahydroisoquinolines: 44
        7,8-dichloro-1,2,3,4-tetrahydroisoquinoline: 8

Experts

1.	Chisari, A N: 1 article (01/2000)
2.	Gaillard, R C: 1 article (01/2000)
3.	Giovambattista, A: 1 article (01/2000)
4.	Spinedi, E: 1 article (01/2000)

Related Diseases

1.	Hemorrhage 08/22/1980 - "These data suggest that the effects of SK&F 64139 are a result of inhibition of central PNMT and that epinephrine may function as a central neurotransmitter mediating cardiovascular responses to hemorrhage, at least under the conditions of these studies." 11/01/1981 - "These results are discussed in relation to our earlier report (Pendleton et al., 1980a) which indicates that the potent inhibitor of epinephrine synthesis, SK & F 64139, will prolong the bradycardia and hypotension associated with hemorrhage in this model."
2.	Bradycardia 12/01/1982 - "Similarly, the bradycardia after clonidine was promptly reversed by i.c.v. SK & F 64139. " 12/01/1982 - "Bradycardia in response to clonidine was also prevented by i.c.v. SK & F 64139. " 11/01/1981 - "These results are discussed in relation to our earlier report (Pendleton et al., 1980a) which indicates that the potent inhibitor of epinephrine synthesis, SK & F 64139, will prolong the bradycardia and hypotension associated with hemorrhage in this model." 08/22/1980 - "The bradycardia, which is abolished by vagotomy and partially antagonized by atropine, was significantly prolonged by pretreatment with SK&F 64139, a potent in vivo inhibitor of peripheral and central (CNS) phenylethanolamine N-methyltransferase (PNMT). "
3.	Hypertension (High Blood Pressure) 07/20/1984 - "SKF 64139, an inhibitor of phenylethanolamine-N-methyltransferase (PNMT), has a marked hypotensive effect in models of sodium-dependent hypertension. " 11/01/1982 - "The mechanisms sustaining high blood pressure in conscious one-kidney, one-clip Goldblatt rats were evaluated with the use of SK&F 64139, a phenylethanolamine N-methyltransferase inhibitor capable of crossing the blood-brain barrier and of captopril, an angiotensin converting enzyme inhibitor. "
4.	Endotoxemia 01/01/2000 - "For this purpose, acute endotoxemia was induced in adult male rats pretreated intraperitoneally with either different inhibitors of phenylethanolamine-N-methyltransferase (PNMT) [which are active either peripherally (SKF 29661) or both peripherally and centrally (SKF 64139), thus lowering epinephrine (EPI) synthesis] or vehicle only (CTRL). "
5.	Lordosis 03/01/1989 - "Inhibition of guinea pig lordosis behavior by the phenylethanolamine N-methyltransferase (PNMT) inhibitor SKF-64139: mediation by alpha noradrenergic receptors."

Related Drugs and Biologics

1.	Epinephrine (Adrenaline)
2.	Neurotransmitter Agents (Neurotransmitter)
3.	Phenylethanolamine N-Methyltransferase
4.	Desoxycorticosterone Acetate (DOCA)
5.	Sodium
6.	Salts
7.	Clonidine (ST 155)
8.	Captopril (Capoten)
9.	Atropine
10.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)

Related Therapies and Procedures

1.	Surgical Instruments (Clip)
2.	Vagotomy