HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
7,8- dichloro- 1,2,3,4- tetrahydroisoquinoline
potent reversible inhibitor of phenylethanolamine N-methyltransferase; structure
Also Known As:
DCTQ; SK&F 64139; SK&F-64139; SKF 64139
Networked:
8
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Isoquinolines: 34
Tetrahydroisoquinolines: 44
7,8-dichloro-1,2,3,4-tetrahydroisoquinoline: 8
Experts
1.
Chisari, A N
: 1 article (01/2000)
2.
Gaillard, R C
: 1 article (01/2000)
3.
Giovambattista, A
: 1 article (01/2000)
4.
Spinedi, E
: 1 article (01/2000)
Related Diseases
1.
Hemorrhage
08/22/1980 - "
These data suggest that the effects of SK&F 64139 are a result of inhibition of central PNMT and that epinephrine may function as a central neurotransmitter mediating cardiovascular responses to hemorrhage, at least under the conditions of these studies.
"
11/01/1981 - "
These results are discussed in relation to our earlier report (Pendleton et al., 1980a) which indicates that the potent inhibitor of epinephrine synthesis, SK & F 64139, will prolong the bradycardia and hypotension associated with hemorrhage in this model.
"
2.
Bradycardia
12/01/1982 - "
Similarly, the bradycardia after clonidine was promptly reversed by i.c.v. SK & F 64139.
"
12/01/1982 - "
Bradycardia in response to clonidine was also prevented by i.c.v. SK & F 64139.
"
11/01/1981 - "
These results are discussed in relation to our earlier report (Pendleton et al., 1980a) which indicates that the potent inhibitor of epinephrine synthesis, SK & F 64139, will prolong the bradycardia and hypotension associated with hemorrhage in this model.
"
08/22/1980 - "
The bradycardia, which is abolished by vagotomy and partially antagonized by atropine, was significantly prolonged by pretreatment with SK&F 64139, a potent in vivo inhibitor of peripheral and central (CNS) phenylethanolamine N-methyltransferase (PNMT).
"
3.
Hypertension (High Blood Pressure)
07/20/1984 - "
SKF 64139, an inhibitor of phenylethanolamine-N-methyltransferase (PNMT), has a marked hypotensive effect in models of sodium-dependent hypertension.
"
11/01/1982 - "
The mechanisms sustaining high blood pressure in conscious one-kidney, one-clip Goldblatt rats were evaluated with the use of SK&F 64139, a phenylethanolamine N-methyltransferase inhibitor capable of crossing the blood-brain barrier and of captopril, an angiotensin converting enzyme inhibitor.
"
4.
Endotoxemia
01/01/2000 - "
For this purpose, acute endotoxemia was induced in adult male rats pretreated intraperitoneally with either different inhibitors of phenylethanolamine-N-methyltransferase (PNMT) [which are active either peripherally (SKF 29661) or both peripherally and centrally (SKF 64139), thus lowering epinephrine (EPI) synthesis] or vehicle only (CTRL).
"
5.
Lordosis
03/01/1989 - "
Inhibition of guinea pig lordosis behavior by the phenylethanolamine N-methyltransferase (PNMT) inhibitor SKF-64139: mediation by alpha noradrenergic receptors.
"
Related Drugs and Biologics
1.
Epinephrine (Adrenaline)
2.
Neurotransmitter Agents (Neurotransmitter)
3.
Phenylethanolamine N-Methyltransferase
4.
Desoxycorticosterone Acetate (DOCA)
5.
Sodium
6.
Salts
7.
Clonidine (ST 155)
8.
Captopril (Capoten)
9.
Atropine
10.
Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
Related Therapies and Procedures
1.
Surgical Instruments (Clip)
2.
Vagotomy