pseurotin

metabolite isolated from culture filtrates of Pseudeurotium ovalis Stolk; structure

Also Known As:

pseurotin A; 2-(1'(S), 2'(S)-dihydroxyhex-3'-ene-yl)-3-methyl-8(S)-methoxy- S-benzoyl-9(R)-hydroxy-(5S)-1-oxa-7-aza-spiro 4.4 non-2-ene-4,6-dione

Networked: 12 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - Pyrrolidinones: 162
      - pseurotin: 12

Experts

1.	Abdelwahed, Khaldoun S: 2 articles (12/2021 - 01/2020)
2.	El Sayed, Khalid A: 2 articles (12/2021 - 01/2020)
3.	King, Judy Ann: 2 articles (12/2021 - 01/2020)
4.	Qusa, Mohammed H: 2 articles (12/2021 - 01/2020)
5.	Siddique, Abu Bakar: 2 articles (12/2021 - 01/2020)
6.	Barbosa, Euzébio Guimarães: 1 article (01/2022)
7.	Chooi, Yit-Heng: 1 article (01/2022)
8.	Geremia, Felipe: 1 article (01/2022)
9.	Perin, Ana Paula A: 1 article (01/2022)
10.	Phan, Chin-Soon: 1 article (01/2022)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2019 - "The present study evaluated the protective effects of pseurotin A against inflammation and the destruction of cartilage in a rat model of rheumatoid arthritis (RA). "
2.	Rheumatoid Arthritis 01/01/2019 - "The present study evaluated the protective effects of pseurotin A against inflammation and the destruction of cartilage in a rat model of rheumatoid arthritis (RA). "
3.	Prostatic Neoplasms (Prostate Cancer) 02/02/2023 - "Towards Developing Novel Prostate Cancer Recurrence Suppressors: Acute Toxicity of Pseurotin A, an Orally Active PCSK9 Axis-Targeting Small-Molecule in Swiss Albino Mice." 12/10/2021 - "PCSK9 Axis-Targeting Pseurotin A as a Novel Prostate Cancer Recurrence Suppressor Lead." 03/28/2023 - "Pseurotin A Validation as a Metastatic Castration-Resistant Prostate Cancer Recurrence-Suppressing Lead via PCSK9-LDLR Axis Modulation." 03/28/2023 - "The fermentation product pseurotin A (PS) suppressed PCSK9 expression, protein-protein interactions with LDLR, and breast and prostate cancer recurrences. " 02/02/2023 - "Preliminary studies revealed that pseurotin A (PsA), a spiro-heterocyclic γ-lactam alkaloid from several marine and terrestrial Aspergillus and Penicillium species, has the ability to dually suppress the PCSK9 expression and protein-protein interaction (PPI) with LDLR, resulting in an anti-hypercholesterolemic effect and modulating the oncogenic role of PCSK9 axis in breast and prostate cancers progression and recurrence. "
4.	Leishmaniasis 01/01/2022 - "Based on the limitations observed in the treatment of leishmaniasis, such as high cost, significant adverse effects, and the potential for drug resistance, the aim of the present study was to evaluate the leishmanicidal activity of the compounds pseurotin A and monomethylsulochrin isolated from the biomass extract of Aspergillus sp. The chromatographic profiles of the extract were determined by high-performance liquid chromatography coupled with a diode-array UV-Vis detector (HPLC-DAD-UV), and the molecular identification of the pseurotin A and monomethylsulochrin were carried out by electrospray ionization mass spectrometry in tandem (LC-ESI-MS-MS) and nuclear magnetic resonance (NMR). "
5.	Seizures (Absence Seizure) 01/01/2018 - "Based on the prominent antiseizure activity in both species and the drug-likeness, we propose pseurotin A2 and azaspirofuran A as lead compounds that are worth further investigation for the treatment of epileptic seizures. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Lactams
3.	Alkaloids
4.	fumagillin
5.	Proteome
6.	LDL Receptors (LDL Receptor)
7.	Mycotoxins
8.	Hormones (Hormone)
9.	Gliotoxin
10.	azaspirofuran A

Related Therapies and Procedures

1.	Castration