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S 6 (S-6)

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RN given refers to di-HCl; structure

Also Known As:

S-6; 4-propionyl-4-(3-chlorophenyl)-1-(3'-dimethylaminopropyl)piperidine dihydrochloride

Networked: 91 relevant articles (5 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Piperidines: 12
    - S 6: 91

Experts

1.	Duke, Colin C: 3 articles (08/2014 - 01/2013)
2.	Buck, Martina: 3 articles (01/2011 - 01/2007)
3.	Tran, Van H: 2 articles (08/2014 - 01/2013)
4.	Roufogalis, Basil D: 2 articles (08/2014 - 01/2013)
5.	Chojkier, Mario: 2 articles (01/2011 - 01/2007)
6.	Cabral, Pablo: 1 article (12/2015)
7.	Tassano, Marcos: 1 article (12/2015)
8.	Fernández, Marcelo: 1 article (12/2015)
9.	Zamboni, Cibele B: 1 article (12/2015)
10.	Kovacs, Luciana: 1 article (12/2015)

Related Diseases

1.	Pain (Aches) 06/01/1996 - "Significant improvement was found in the profile's 6 subscales, with energy, pain, and physical mobility significant at the 0.001 level, emotion and social isolation significant at the 0.005 level, and sleep significant at the 0.05 level. " 12/01/2013 - "This paper describes a blueprint of pain content and teaching methods across the University of Washington's 6 health sciences schools and provides recommendations for improvement in pain education at the prelicensure level. " 01/01/2007 - "To determine whether Rocabado's 6 x 6 exercise program has an added benefit to self-care alone in reducing myofascial jaw pain and improving forward head posture (FHP) in subjects with myofascial pain and FHP at the end of 4 weeks. " 02/01/1982 - "The therapeutic value of buprenorphine was investigated in 31 patients suffering from moderate to severe cancer pain by intramuscular administration at the single doses of 0.2 mg and 0.3 mg in comparison with pentazocine 30 mg. Analgesic effect of buprenorphine 0.3 mg was significantly superior to buprenorphine 0.2 mg and pentazocine 30 mg. The duration of analgesia with buprenorphine was 9 hours at 0.2 mg and 11 hours at 0.3 mg, which were markedly longer than pentazocine's 6 hours. "
2.	Lung Injury 01/01/2011 - "Here we show that blocking the ribosomal S-6 kinase (RSK) phosphorylation of the CCAAT/Enhancer Binding Protein (C/EBP)-β on Thr217 (a RSK phosphoacceptor) with either a single point mutation (Ala217), dominant negative transgene or a blocking peptide containing the mutated phosphoacceptor ameliorates the progression of lung injury and fibrosis induced by Bleomycin in mice. " 05/01/2013 - "Treatment with lipoxin A4 and lipoxin receptor agonist (5(S), 6(R)-7-trihydroxymethyl 17 heptanoate) significantly stimulated AFC in oleic acid (OA)-induced lung injury, with the outcome of decreased pulmonary edema. "
3.	Fibrosis (Cirrhosis) 09/01/1995 - "Eight patients with active pulmonary sarcoidosis (S), 6 with idiopathic pulmonary fibrosis (IPF) and 6 with focal lung fibrosis due to inactive pulmonary tuberculosis (hTB) were studied. " 01/01/2011 - "Here we show that blocking the ribosomal S-6 kinase (RSK) phosphorylation of the CCAAT/Enhancer Binding Protein (C/EBP)-β on Thr217 (a RSK phosphoacceptor) with either a single point mutation (Ala217), dominant negative transgene or a blocking peptide containing the mutated phosphoacceptor ameliorates the progression of lung injury and fibrosis induced by Bleomycin in mice. "
4.	Reperfusion Injury 04/06/2010 - "Here, we evaluated the efficacy of 5 (S), 6 (R)-lipoxin A(4) methyl ester (LXA(4) ME), a stable synthetic analogue of lipoxin A(4) in cerebral ischemia reperfusion injury in rats. "
5.	Erythema 01/01/2008 - "His erythema improved rapidly with steroid therapy and he underwent a segmentectomy (S(6)) of the right lower lobe. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	CCAAT-Enhancer-Binding Proteins
3.	Lipoxins
4.	Bleomycin (Blenoxane)
5.	S(8)
6.	Nitric Oxide (Nitrogen Monoxide)
7.	lipoxin A4
8.	CCAAT-Enhancer-Binding Protein-beta
9.	Multidrug Resistance-Associated Proteins
10.	Naproxen (Naprosyn)

Related Therapies and Procedures

1.	Segmental Mastectomy (Lumpectomy)
2.	Thyroidectomy
3.	Bone Transplantation (Bone Grafting)
4.	Chinese Traditional Medicine (Traditional Chinese Medicine)
5.	Debridement