oridonin

Antineoplastic Agents, Phytogenic from Isodon; structure; RN given refers to (alpha,6beta,7alpha,14R)-isomer; RN for parent cpd not available 10;90

Also Known As:

lasidonin; oridonin, (1alpha,5alpha,6alpha,7beta,8beta,9alpha,10beta,13beta,14S)-isomer; oridonin, (1alpha,6beta,7alpha,11alpha)-isomer; oridonin, (1alpha,6beta,7alpha,11beta)-isomer

Networked: 418 relevant articles (40 outcomes, 127 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Kaurane Diterpenes: 93
        oridonin: 418

Experts

1.	Ikejima, Takashi: 31 articles (12/2015 - 06/2004)
2.	Onodera, Satoshi: 30 articles (12/2015 - 06/2004)
3.	Tashiro, Shin-Ichi: 18 articles (12/2015 - 06/2004)
4.	Xu, Jinyi: 13 articles (01/2020 - 08/2008)
5.	Zhou, Jia: 12 articles (07/2021 - 06/2013)
6.	Tashiro, Shin-ichi: 12 articles (01/2012 - 10/2004)
7.	Li, Dahong: 11 articles (01/2020 - 06/2012)
8.	Liu, Ying: 10 articles (06/2021 - 07/2008)
9.	Xu, Shengtao: 10 articles (01/2020 - 06/2012)
10.	Ke, Yu: 9 articles (02/2022 - 11/2016)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2014 - "The anti-tumor efficacy of oridonin was dose-dependent and showed strong inhibition of c-Met phosphorylation. " 06/01/2013 - "All target compounds showed improved anti-proliferative activities against four human cancer cell lines compared with natural oridonin and parent compound 10. " 09/01/2023 - "Recent studies have found that Oridonin (Ori) has anti-tumor effects by regulating pyroptosis through various pathways. " 01/01/2023 - "Studies have demonstrated that oridonin, by inhibiting AKT signaling that regulates Mcl-1 expression, can effectively suppress tumor cell growth. " 11/14/2018 - "The present study demonstrated that oridonin exhibited an anti-tumor effect on GC SNU-216 cells through regulating p53 expression and function."
2.	Breast Neoplasms (Breast Cancer) 11/14/2013 - "Oridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis." 08/01/2018 - "The results of the present study suggest that oridonin may be a promising anti-metastatic agent in breast cancer treatment." 08/01/2018 - "In the present study, oridonin significantly suppressed the migration, invasion and adhesion of MDA-MB-231 and 4T1 breast cancer cells, and inhibited tube formation of human umbilical vein endothelial cells in a dose-dependent manner. " 01/01/2013 - "To study the mechanisms of inhibition of cell growth and induction of DNA damage in oridonin-treated MCF-7 human breast cancer cells. " 01/01/2013 - "In this study, we investigated the effects of oridonin on growth, migration and invasion of highly-metastatic human breast cancer cells. "
3.	Ischemic Stroke 10/01/2021 - "The aim of the present study was to investigate the protective effects of oridonin on oxidative stress-induced endothelial injury in ischaemic stroke. " 04/01/2023 - "Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy." 10/01/2021 - "Oridonin prevents oxidative stress-induced endothelial injury via promoting Nrf-2 pathway in ischaemic stroke." 10/01/2021 - "Our findings revealed the therapeutic effect and mechanism of oridonin in ischaemic stroke, which provided fundamental evidence for developing the extracted compound of Chinese herbal medicine into an innovative drug for ischaemic stroke treatment." 10/01/2021 - "We found oridonin repaired blood-brain barrier (BBB) integrity presented with upregulation of tight junction proteins (TJ proteins) expression, inhibited the infiltration of periphery inflammatory cells and neuroinflammation and thereby reduced infarct volume in ischaemic stroke mice. "
4.	Inflammation (Inflammations) 05/01/2021 - "Oridonin ameliorates inflammation-induced bone loss in mice via suppressing DC-STAMP expression." 05/04/2020 - "This study aimed to assess the kidney-protective role of Oridonin in AKI and the underlying mechanism by which Oridonin improves AKI in vivo and inhibits inflammation in LPS-induced bone marrow-derived macrophages (BMDM) in vitro. " 05/05/2018 - "In the present study, we explore the role of oridonin in regulating endothelial inflammation and its underlying mechanism. " 08/01/2023 - "Oridonin could significantly inhibit inflammation associated with NLRP3 activation. " 01/01/2023 - "0.1-2 μM of oridonin had no significant cytotoxicity on the growth of hPDLSCs, while 2 μM of oridonin could not only greatly reduce the inhibitory effect of LPS on the proliferation and osteogenic differentiation of hPDLSCs cells, but also inhibit LPS-induced inflammation and ER stress in hPDLSCs cells. "
5.	Leukemia 01/01/2017 - "Collectively, our results identify a novel mechanism by which oridonin induces rapid degradation of BCR-ABL as well as a novel pharmaceutical activator of HSF1 that represents a promising treatment for leukemia." 04/10/2015 - "In addition, primary leukemia cells were treated with oridonin and analyzed by western blot in this study. " 01/01/2005 - "In this study, we investigated the apoptotic inducing effect of oridonin in leukemia K562 cells and its mechanism. " 01/01/2023 - "Interestingly, JOA possessed stronger anti-leukemia activity than its analogues such as OGP46 and Oridonin, which has been investigated extensively. " 10/18/2021 - "Overall, oridonin is a potential and promising drug candidate or lead compound targeting DNMT3A R882 mutation-driven clonal hematopoiesis and leukemia."

Related Drugs and Biologics

1.	Diterpenes
2.	Doxorubicin (Adriamycin)
3.	Inflammasomes
4.	Proteins (Proteins, Gene)
5.	Cisplatin (Platino)
6.	Kaurane Diterpenes
7.	Reactive Oxygen Species (Oxygen Radicals)
8.	Lipopolysaccharides
9.	Catenins
10.	Antioxidants

Related Therapies and Procedures

1.	Punctures
2.	Ligation
3.	Therapeutics
4.	Chinese Traditional Medicine (Traditional Chinese Medicine)
5.	Drug Therapy (Chemotherapy)