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nabilone (Cesamet)

cannabinol deriv; RN given refers to cpd without isomeric designation; structure

Also Known As:

Cesamet; LY 109514; Lilly 109514; Lilly Brand of Nabilone; nabilone, (6aR-trans)-isomer; nabilone, (6aS-trans)-isomer; nabilone, (cis-(+-))-isomer; nabilone, (trans-(+-))-isomer; 3-(1,1-dimethylheptyl)-6,6a,7,8,10,10a- hexahydro-1-hydroxy-6,6-dimethyl-9H-dibenzo(b,d)pyran-9-one

Networked: 118 relevant articles (20 outcomes, 34 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Hydrocarbons: 412
  - Terpenes: 260
    - Cannabinoids: 1257
      - Tetrahydrocannabinol: 997
        nabilone: 118

Experts

1.	Ware, Mark A: 5 articles (04/2015 - 01/2006)
2.	Ethans, Karen: 3 articles (01/2015 - 02/2008)
3.	Maida, Vincent: 3 articles (03/2008 - 01/2007)
4.	Hill, Kevin P: 2 articles (06/2015 - 09/2014)
5.	Gomori, Andrew: 2 articles (01/2015 - 12/2009)
6.	Esfahani, Farid: 2 articles (01/2015 - 12/2009)
7.	Turcotte, Dana: 2 articles (01/2015 - 12/2009)
8.	Bedi, Gillinder: 2 articles (09/2013 - 07/2013)
9.	Haney, Margaret: 2 articles (09/2013 - 07/2013)
10.	Cooper, Ziva D: 2 articles (09/2013 - 07/2013)

Related Diseases

1.	Pain (Aches) 01/01/2006 - "Fifteen patients reported subjective overall improvement with nabilone, and nine reported reduced pain intensity. " 10/01/2006 - "To evaluate the safety and efficacy of low dose treatment with the synthetic cannabinoid Nabilone (1 mg per day) on spasticity-related pain a placebo-controlled double-blind crossover trial was performed.11 out of 13 included patients completed the study. " 01/01/2013 - "Following the starting of nabilone (a synthetic cannabinoid) his pain control was greatly improved and this had a huge impact on his quality of life. " 12/01/2000 - "Patients taking the synthetic derivative nabilone for neurogenic pain actually preferred cannabis herb and reported that it relieved not only pain but the associated depression and anxiety. " 01/01/2015 - "After adjustment for key patient-level covariates (e.g., age, sex, Expanded Disability Status Scale, duration of MS, baseline pain), a significant group × time(2) interaction term was reported for both the VASpain (P < 0.01) and VASimpact score (P < 0.01), demonstrating the adjusted rate of decrease for both outcomes was statistically greater in nabilone vs placebo study group. "
2.	Vomiting 08/01/1985 - "The pharmacological profile of nabilone suggests that it acts primarily by preventing emesis controlled by the medulla oblongata, although its secondary mild anxiolytic activity may contribute to the overall efficacy. " 11/01/1983 - "Fewer subjects vomited with nabilone (P = 0.05) and the number of vomiting episodes was lower (P less than 0.05); no patients on nabilone required additional parenteral anti-emetic. " 01/01/2003 - "The cannabinoid nabilone is currently licensed for use as an antiemetic agent in chemotherapy-induced emesis. " 07/01/1984 - "Nabilone is a cannabinoid anti-emetic which has been extensively evaluated in control of chemotherapy-induced vomiting. " 12/01/1982 - "Use of nabilone in the treatment of chemotherapy-induced vomiting in an outpatient setting."
3.	Nausea 03/01/2008 - "Other ESAS parameters that improved significantly in patients receiving nabilone were nausea (P < 0.0001), anxiety (P = 0.0284) and overall distress (total ESAS score; P = 0.0208). " 03/01/2009 - "Nabilone, a synthetic derivative of Delta9-tetrahydrocannabinol (Delta9-THC), which is the main natural psychotropic constituent of C sativa, was approved by the US FDA for the treatment of nausea and as an anti-emetic for patients undergoing chemotherapy. " 01/01/2014 - "In this case report, we present 20-year-old woman who developed protracted nausea and vomiting secondary to cannabis withdrawal and was successfully treated with nabilone. " 01/01/2014 - "Nabilone therapy for cannabis withdrawal presenting as protracted nausea and vomiting." 02/01/2010 - "The most common AEs for nabilone were dizziness, nausea, and dry mouth. "
4.	Neoplasms (Cancer) 02/01/2008 - "Clinical trials have demonstrated the benefits of nabilone in cancer chemotherapy patients. " 12/01/1982 - "Double-blind, randomized, crossover trial of nabilone vs. placebo in cancer chemotherapy." 06/01/1987 - "Nabilone appears to be a safe, effective, and well-tolerated antiemetic drug for children receiving cancer chemotherapy. " 05/01/1986 - "Nabilone: an alternative antiemetic for cancer chemotherapy." 08/01/1985 - "Thus, nabilone offers an effective alternative to the treatment options available in a difficult therapeutic area - those patients with severe gastrointestinal side effects from cancer chemotherapy who are refractory to conventional therapy."
5.	Post-Traumatic Stress Disorders (PTSD) 01/01/2015 - "The efficacy of nabilone, a synthetic cannabinoid, in the treatment of PTSD-associated nightmares: A preliminary randomized, double-blind, placebo-controlled cross-over design study." 01/01/2015 - "Investigate the efficacy of nabilone capsules (NAB) in reducing the frequency and intensity of nightmares in subjects with PTSD. " 01/01/2015 - "However, several failed clinical trials have diminished enthusiasm for the continued development of eCB-targeted therapeutics for psychiatric disorders, despite the encouraging preclinical data and promising preliminary results obtained with the synthetic cannabinoid nabilone for treating post-traumatic stress disorder. " 01/01/2009 - "The results of this study indicate the potential benefits of nabilone, a synthetic cannabinoid, in patients with PTSD experiencing poor control of nightmares with standard pharmacotherapy. " 01/01/2015 - "There is a need for further exploration of the effect of nabilone on other symptoms of PTSD such as re-experiencing, hyper vigilance and insomnia."

Related Drugs and Biologics

1.	Tetrahydrocannabinol (THC)
2.	Cisplatin (Platino)
3.	Metoclopramide (Reglan)
4.	Dexamethasone (Maxidex)
5.	Cannabinoids
6.	Cannabinoid Receptors (Cannabinoid Receptor)
7.	Levodopa (L Dopa)
8.	Amitriptyline (Elavil)
9.	gabapentin (Neurontin)
10.	oleoylethanolamide

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Therapeutics
4.	Off-Label Use
5.	Patient-Controlled Analgesia (Analgesia, Patient Controlled)