kojic acid

04/01/1999 - "In 2 patients, there was complete clearance of melasma, and this was on the side where kojic acid was used. "
04/01/1999 - "More than half of the melasma cleared in 24/40 (60%) patients receiving kojic acid compared to 19/40 (47.5%) patients receiving the gel without kojic acid. "
07/01/2020 - "Kojic acid has been shown to be effective in reducing melasma severity and is now increasingly used in cosmetic treatments. "
01/01/2020 - "We discuss the background of kojic acid, its suggested mechanism, and the available studies evaluating its utility in treating melasma."
01/01/2020 - "Kojic Acid for Melasma: Popular Ingredient in Skincare Products."

04/04/2023 - "Aim: The aim of this study was to demonstrate the effects of using a preparation containing kojic acid on skin hyperpigmentation using hyperspectral imaging, which enables a quantitative assessment of the effect of the preparation used on the reduction of skin discoloration. "
04/04/2023 - "Evaluation of the Reduction of Skin Hyperpigmentation Changes under the Influence of a Preparation Containing Kojic Acid Using Hyperspectral Imaging-Preliminary Study."
04/04/2023 - "A hyperspectral camera with a spectral range of 400-1000 nm was used to image skin hyperpigmentation before and after the application of 3% kojic acid. "
12/01/2022 - "Whitening effect of kojic acid dipalmitate loaded nanosized ethosomal gel for the treatment of hyperpigmentation: In vitro and in vivo characterization."
10/01/2023 - "The observations of this study revealed that the produced kojisome might be used as a potential nano-vehicle for kojic acid dermal administration, thereby opening up innovative options for the treatment of hyperpigmentation problems."

06/01/2012 - "Although in human clinical studies kojic acid has been shown to be effective in the treatment of hyper-pigmentation disorders such as melasma, the reasons for its apparent lack of anti-melanogenic activity in cultured mammalian melanocytes are unclear. "

10/01/2021 - "Moreover, the total phenolic content (31.18 - 54.51 mg gallic acid equivalents/g extract) and antioxidant and enzyme inhibitory activities of the seeds have been evaluated and showed strong antioxidant properties (44.42 - 516.81 mg gallic acid equivalents/g extract) as well as satisfactory bleaching (enzyme tyrosinase, 16.95 - 23.80 mg kojic acid equivalents/g extract), antidiabetic (enzymes a-amylase, a-glucosidase, 0.14 - 1.75 mmol acarbose equivalents/g extract), and protective against neurodegenerative disease (cholinesterase enzymes, 0.49 - 1.22 mg galanthamine equivalents/g extract) activities. "

12/15/2017 - "7C and 5,7C decreased the body pigmentation at 5 µg/mL, while did not affect the embryos development and survival at doses ≤50 µg/mL and ≤25 µg/mL. Unlike hydroquinone and kojic acid, 4-phenyl hydroxycoumarins were no melanocytotoxic, showed no cardiotoxic side effects, neither caused neutropenia in zebrafish embryos, suggesting these compounds may present novel skin-whitening agents with improved pharmacological properties. "