HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

coronardine

RN given refers to parent cpd without isomeric designation; structure

Also Known As:

coronardine monohydrochloride; coronardine monohydrochloride, (+-)-isomer; coronaridine

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Adams, David J: 1 article (01/2020)
2.	Arias, Hugo R: 1 article (01/2020)
3.	Di Cesare Mannelli, Lorenzo: 1 article (01/2020)
4.	Ghelardini, Carla: 1 article (01/2020)
5.	Micheli, Laura: 1 article (01/2020)
6.	Tae, Han-Shen: 1 article (01/2020)
7.	Yousuf, Arsalan: 1 article (01/2020)
8.	Ahmed, Firoj: 1 article (09/2015)
9.	Arai, Midori A: 1 article (09/2015)
10.	Ishibashi, Masami: 1 article (09/2015)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2013 - "The aim of present study was firstly to screen the cytotoxic activity of the indole alkaloids heyneanine, coronaridine and voacangine against HeLa (human cervix tumor), 3T3 (normal mouse embryo fibroblasts), Hep-2 (human laryngeal epithelial carcinoma) and B-16 (murine skin) cell lines by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide); and secondly to analyze the apoptotic activity, cell membrane damage and genotoxicity of the compound that showed the best cytotoxic activity against the tumor cell lines tested. "
2.	Carcinoma (Carcinomatosis) 03/01/2013 - "Cytotoxicity and genotoxicity of coronaridine from Tabernaemontana catharinensis A.DC in a human laryngeal epithelial carcinoma cell line (Hep-2)." 03/01/2013 - "Coronaridine was the one that exhibited greater cytotoxic activity in the laryngeal carcinoma cell line Hep-2 (IC50 = 54.47 μg/mL) than the other alkaloids tested (voacangine IC50 = 159.33 g/mL, and heyneanine IC50 = 689.45 μg/mL). " 03/01/2013 - "The aim of present study was firstly to screen the cytotoxic activity of the indole alkaloids heyneanine, coronaridine and voacangine against HeLa (human cervix tumor), 3T3 (normal mouse embryo fibroblasts), Hep-2 (human laryngeal epithelial carcinoma) and B-16 (murine skin) cell lines by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide); and secondly to analyze the apoptotic activity, cell membrane damage and genotoxicity of the compound that showed the best cytotoxic activity against the tumor cell lines tested. "
3.	Neuralgia (Stump Neuralgia) 01/01/2020 - "Considering the potency of the coronaridine congeners at Cav2.2 channels and α9α10 nAChRs, and the calculated brain concentration of (+)-catharanthine, it is plausible that the observed anti-neuropathic pain effects are mediated by peripheral and central mechanisms involving the inhibition of α9α10 nAChRs and/or CaV2.2 channels." 01/01/2020 - "Coronaridine congeners decrease neuropathic pain in mice and inhibit α9α10 nicotinic acetylcholine receptors and CaV2.2 channels." 01/01/2020 - "The results showed that both coronaridine congeners induce anti-neuropathic pain activity at a dose of 72 mg/kg (per os), whereas a lower dose (36 mg/kg) of (+)-catharanthine decreased the progress of oxaliplatin-induced neuropathic pain. "
4.	Neoplasm Metastasis (Metastasis) 01/01/2022 - "Coronaridine, a Wnt/β-catenin-specific antagonist, blocked SCG cell growth and metastasis induced by WASF2. "
5.	Colonic Neoplasms (Colon Cancer) 09/15/2015 - "Of these, coronaridine (3) decreased β-catenin levels in SW480 colon cancer cells, while this decrease in β-catenin was not suppressed by a co-treatment with 3 and MG132, a proteasome inhibitor. "

Related Drugs and Biologics

1.	Indole Alkaloids
2.	Bromides
3.	voacangine
4.	Catenins
5.	Proteasome Inhibitors
6.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
7.	Alkaloids
8.	Oxaliplatin (Eloxatin)
9.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde
10.	catharanthine