benoxaprofen

RN given refers to parent cpd; structure

Also Known As:

LRCL 3794; Oraflex; benoxaprofen, (+)-isomer; benoxaprofen, (+-)-isomer; benoxaprofen, (-)-isomer; benoxaprofen, ammonium salt; benoxaprofen, monosodium salt; 2-(4-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid

Networked: 125 relevant articles (10 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Propionates: 988
      - benoxaprofen: 125
Lipids: 114793
- Fatty Acids: 27405
  - Volatile Fatty Acids: 3052
    - Propionates: 988
      - benoxaprofen: 125

Experts

1.	Chin, Kuen Yeow: 1 article (03/2012)
2.	El-Kayat, Bara: 1 article (03/2012)
3.	Hart, Andrew: 1 article (03/2012)
4.	Milne, Alistair: 1 article (03/2012)

Related Diseases

1.	Rheumatoid Arthritis 01/01/1982 - "Rheumatoid arthritis patients showed significant improvement in most measurements with both drugs, but overall results favored benoxaprofen, particularly in erythrocyte sedimentation rate and physician's global assessment. " 01/01/1980 - "Dose-range studies of benoxaprofen compared with placebo in patients with active rheumatoid arthritis." 11/01/1978 - "A double-blind cross-over trial showed that benoxaprofen was effective and well tolerated in rheumatoid arthritis. " 01/01/1980 - "The new nonsteroidal antiinflammatory drug benoxaprofen was compared with placebo in separate double-blind crossover studies in patients with active rheumatoid arthritis given 400 mg, 600 mg, or 800 mg a day. " 05/01/1979 - "Treatment of rheumatoid arthritis with a single daily dose of benoxaprofen."
2.	Osteoarthritis 08/13/1982 - "[Treatment of severe activated arthrosis with Benoxaprofen]." 01/01/1982 - "A multicentre comparative crossover study of benoxaprofen in the treatment of osteoarthritis was undertaken by general practitioners in the United Kingdom. " 01/01/1982 - "Benoxaprofen plasma profiles were obtained in 10 elderly patients (mean age 77 years) suffering from osteoarthritis and various underlying diseases. " 01/01/1980 - "Long-term treatment of symptomatic osteoarthritis with benoxaprofen. " 01/01/1982 - "Studies with benoxaprofen in rheumatoid arthritis and osteoarthritis, conducted in more than 2000 patients, continue to demonstrate its safety and effectiveness. "
3.	Pain (Aches) 06/11/1983 - "The results showed that benoxaprofen improved clinical parameters of disease activity, including morning stiffness, walking time, tenderness and swelling of joints and pain rating, in 7 of the 10 patients studied. " 01/01/1980 - "Statistically significant differences in favor of benoxaprofen were found for knee flexion and pain relief. " 01/01/1982 - "Both indomethacin and benoxaprofen led to a statistically significant improvement (alpha less than or equal to 0.05) of the subjective (measured by a pain score) and the objective joint status (range of motion evaluation) as compared to the pretreatment status. " 01/01/1980 - "Both benoxaprofen (600 mg once daily) and ibuprofen (400 mg qid) improved measurements of pain, stiffness, range of movement, mobility, patient preference, and overall assessment. " 01/01/1983 - "Comparison of the results of first treatments showed that 'Osmosin' was significantly better than placebo and at least as effective as benoxaprofen in reducing pain scores, particularly day and weight-bearing pain. "
4.	Psoriasis (Pustulosis Palmaris et Plantaris) 07/01/1983 - "Twenty-four patients with psoriasis completed a double-blind trial of benoxaprofen for their cutaneous lesions. " 01/01/1985 - "These results are compatible with the idea that benoxaprofen may improve psoriasis by interfering with monocyte function." 01/01/1985 - "To assess a potential pathogenic role of enhanced monocyte function in psoriasis, we determined monocyte chemotaxis and monocyte antibody-dependent cell-mediated cytotoxicity (ADCC) at week 0, 2, 4 and 8 in psoriatics being treated with benoxaprofen. " 01/01/1985 - "Enhanced monocyte activity is present in psoriasis, and benoxaprofen is a drug that inhibits several aspects of monocyte function. " 01/01/1985 - "Normalization of monocyte chemotaxis precedes clinical resolution of psoriasis treated with benoxaprofen."
5.	Arthritis (Polyarthritis) 08/12/1982 - "Food and Drug Administration (FDA) internal documents released this month by a House subcommittee allege that Eli Lilly and Company, which recently suspended sales of the anti-arthritis drug benoxaprofen, has repeatedly failed to report adverse effects of drugs it was testing or marketing. " 07/01/1982 - "The effect of benoxaprofen was examined on adjuvant-induced arthritis in rats by radiographic assessment of bone damage. " 01/01/1982 - "The ability of benoxaprofen to suppress bone damage associated with adjuvant-induced arthritis in rats was studied radiographically over a 49-day period. " 11/01/1982 - "Benoxaprofen: a new arthritis medication that causes phototoxicity." 01/01/1980 - "Benoxaprofen was also moderately active in inhibiting developing adjuvant-induced arthritis; however, it exhibited a potent response in established adjuvant arthritis, and it was the only compound tested which showed marked inhibition of the directional movement of mononuclear cells. "

Related Drugs and Biologics

1.	Indomethacin (Indometacin)
2.	benoxaprofen
3.	Ibuprofen (Motrin)
4.	Lipoxygenase (Lipoxygenase-1)
5.	Lipoxygenase Inhibitors
6.	Analgesics (Analgesic Drugs)
7.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
8.	Arachidonic Acid (Vitamin F)
9.	5,8,11,14-Eicosatetraynoic Acid (5,8,11,14 Eicosatetraynoic Acid)
10.	Masoprocol (Actinex)

Related Therapies and Procedures

1.	Therapeutics
2.	Intra-Articular Injections
3.	Renal Dialysis (Hemodialysis)