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benoxaprofen

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RN given refers to parent cpd; structure

Also Known As:

LRCL 3794; Oraflex; benoxaprofen, (+)-isomer; benoxaprofen, (+-)-isomer; benoxaprofen, (-)-isomer; benoxaprofen, ammonium salt; benoxaprofen, monosodium salt; 2-(4-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid

Networked: 121 relevant articles (10 outcomes, 24 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	El-Kayat, Bara: 1 article (03/2012)
2.	Chin, Kuen Yeow: 1 article (03/2012)
3.	Hart, Andrew: 1 article (03/2012)
4.	Milne, Alistair: 1 article (03/2012)

Related Diseases

1.	Rheumatoid Arthritis 01/01/1982 - "Rheumatoid arthritis patients showed significant improvement in most measurements with both drugs, but overall results favored benoxaprofen, particularly in erythrocyte sedimentation rate and physician's global assessment. " 01/01/1982 - "Our study of 39 patients with rheumatoid arthritis suggests a trend for benoxaprofen therapy given over a prolonged period to retard the rheumatologic process when measured radiologically by both osseous defect and joint space narrowing rates. " 01/01/1980 - "Dose-range studies of benoxaprofen compared with placebo in patients with active rheumatoid arthritis." 11/01/1978 - "A double-blind cross-over trial showed that benoxaprofen was effective and well tolerated in rheumatoid arthritis. " 01/01/1982 - "Radiologic assessment of benoxaprofen therapy in rheumatoid arthritis."
2.	Osteoarthritis 01/01/1982 - "Benoxaprofen plasma profiles were obtained in 10 elderly patients (mean age 77 years) suffering from osteoarthritis and various underlying diseases. " 01/01/1982 - "A multicentre comparative crossover study of benoxaprofen in the treatment of osteoarthritis was undertaken by general practitioners in the United Kingdom. " 01/01/1980 - "Long-term treatment of symptomatic osteoarthritis with benoxaprofen. " 01/01/1982 - "Significant clinical improvement was apparent after one week of benoxaprofen therapy in rheumatoid arthritis and osteoarthritis. " 11/01/1982 - "Benoxaprofen undergoes hepatic metabolism via glucuronidation as the primary route of elimination and has a half-life of 28-35 hr. Clinical trials have demonstrated that its analgesic and anti-inflammatory properties are useful in the management of the signs and symptoms of rheumatoid arthritis and osteoarthritis. "
3.	Pain (Aches) 06/11/1983 - "The results showed that benoxaprofen improved clinical parameters of disease activity, including morning stiffness, walking time, tenderness and swelling of joints and pain rating, in 7 of the 10 patients studied. " 01/01/1980 - "Assessments of pain, function, and analgesic consumption showed that benoxaprofen had analgesic activity at all dose levels. " 01/01/1980 - "Statistically significant differences in favor of benoxaprofen were found for knee flexion and pain relief. " 02/01/1987 - "Most were taking benoxaprofen for osteoarthritis (53%) or non-specific musculoskeletal pain (39.9%). " 06/01/1977 - "Benoxaprofen has analgesic activity in tests where pain is accompanied by inflammation but not in other experimental models of pain. "
4.	Psoriasis (Pustulosis Palmaris et Plantaris) 07/01/1983 - "Twenty-four patients with psoriasis completed a double-blind trial of benoxaprofen for their cutaneous lesions. " 01/01/1985 - "These results are compatible with the idea that benoxaprofen may improve psoriasis by interfering with monocyte function." 01/01/1985 - "To assess a potential pathogenic role of enhanced monocyte function in psoriasis, we determined monocyte chemotaxis and monocyte antibody-dependent cell-mediated cytotoxicity (ADCC) at week 0, 2, 4 and 8 in psoriatics being treated with benoxaprofen. " 01/01/1985 - "Enhanced monocyte activity is present in psoriasis, and benoxaprofen is a drug that inhibits several aspects of monocyte function. " 01/01/1985 - "Normalization of monocyte chemotaxis precedes clinical resolution of psoriasis treated with benoxaprofen."
5.	Arthritis (Polyarthritis) 11/01/1982 - "Benoxaprofen (Opren) is a nonsteroidal anti-inflammatory agent used in the treatment of arthritis. " 07/01/1982 - "The effect of benoxaprofen was examined on adjuvant-induced arthritis in rats by radiographic assessment of bone damage. " 01/01/1982 - "The ability of benoxaprofen to suppress bone damage associated with adjuvant-induced arthritis in rats was studied radiographically over a 49-day period. " 11/01/1982 - "Benoxaprofen: a new arthritis medication that causes phototoxicity." 01/01/1980 - "Benoxaprofen was also moderately active in inhibiting developing adjuvant-induced arthritis; however, it exhibited a potent response in established adjuvant arthritis, and it was the only compound tested which showed marked inhibition of the directional movement of mononuclear cells. "

Related Drugs and Biologics

1.	Indomethacin (Indometacin)
2.	benoxaprofen
3.	Ibuprofen (Motrin)
4.	Lipoxygenase (Lipoxygenase-1)
5.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
6.	Lipoxygenase Inhibitors
7.	Arachidonic Acid (Vitamin F)
8.	5,8,11,14-Eicosatetraynoic Acid (5,8,11,14 Eicosatetraynoic Acid)
9.	Nordihydroguaiaretic Acid (Masoprocol)
10.	12,20- dihydroxy- 5,8,10,14- eicosatetraenoic acid

Related Therapies and Procedures

1.	Intra-Articular Injections
2.	Renal Dialysis (Hemodialysis)