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benoxaprofen
RN given refers to parent cpd; structure
Also Known As:
LRCL 3794; Oraflex; benoxaprofen, (+)-isomer; benoxaprofen, (+-)-isomer; benoxaprofen, (-)-isomer; benoxaprofen, ammonium salt; benoxaprofen, monosodium salt; 2-(4-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid
Networked:
125
relevant articles (
10
outcomes,
24
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Carboxylic Acids: 973
Acyclic Acids
Propionates: 988
benoxaprofen: 125
Lipids: 114793
Fatty Acids: 27405
Volatile Fatty Acids: 3052
Propionates: 988
benoxaprofen: 125
Experts
1.
Chin, Kuen Yeow
: 1 article (03/2012)
2.
El-Kayat, Bara
: 1 article (03/2012)
3.
Hart, Andrew
: 1 article (03/2012)
4.
Milne, Alistair
: 1 article (03/2012)
Related Diseases
1.
Rheumatoid Arthritis
01/01/1982 - "
Rheumatoid arthritis patients showed significant improvement in most measurements with both drugs, but overall results favored benoxaprofen, particularly in erythrocyte sedimentation rate and physician's global assessment.
"
01/01/1980 - "
Dose-range studies of benoxaprofen compared with placebo in patients with active rheumatoid arthritis.
"
11/01/1978 - "
A double-blind cross-over trial showed that benoxaprofen was effective and well tolerated in rheumatoid arthritis.
"
01/01/1980 - "
The new nonsteroidal antiinflammatory drug benoxaprofen was compared with placebo in separate double-blind crossover studies in patients with active rheumatoid arthritis given 400 mg, 600 mg, or 800 mg a day.
"
05/01/1979 - "
Treatment of rheumatoid arthritis with a single daily dose of benoxaprofen.
"
2.
Osteoarthritis
08/13/1982 - "
[Treatment of severe activated arthrosis with Benoxaprofen].
"
01/01/1982 - "
A multicentre comparative crossover study of benoxaprofen in the treatment of osteoarthritis was undertaken by general practitioners in the United Kingdom.
"
01/01/1982 - "
Benoxaprofen plasma profiles were obtained in 10 elderly patients (mean age 77 years) suffering from osteoarthritis and various underlying diseases.
"
01/01/1980 - "
Long-term treatment of symptomatic osteoarthritis with benoxaprofen.
"
01/01/1982 - "
Studies with benoxaprofen in rheumatoid arthritis and osteoarthritis, conducted in more than 2000 patients, continue to demonstrate its safety and effectiveness.
"
3.
Pain (Aches)
06/11/1983 - "
The results showed that benoxaprofen improved clinical parameters of disease activity, including morning stiffness, walking time, tenderness and swelling of joints and pain rating, in 7 of the 10 patients studied.
"
01/01/1980 - "
Statistically significant differences in favor of benoxaprofen were found for knee flexion and pain relief.
"
01/01/1982 - "
Both indomethacin and benoxaprofen led to a statistically significant improvement (alpha less than or equal to 0.05) of the subjective (measured by a pain score) and the objective joint status (range of motion evaluation) as compared to the pretreatment status.
"
01/01/1980 - "
Both benoxaprofen (600 mg once daily) and ibuprofen (400 mg qid) improved measurements of pain, stiffness, range of movement, mobility, patient preference, and overall assessment.
"
01/01/1983 - "
Comparison of the results of first treatments showed that 'Osmosin' was significantly better than placebo and at least as effective as benoxaprofen in reducing pain scores, particularly day and weight-bearing pain.
"
4.
Psoriasis (Pustulosis Palmaris et Plantaris)
07/01/1983 - "
Twenty-four patients with psoriasis completed a double-blind trial of benoxaprofen for their cutaneous lesions.
"
01/01/1985 - "
These results are compatible with the idea that benoxaprofen may improve psoriasis by interfering with monocyte function.
"
01/01/1985 - "
To assess a potential pathogenic role of enhanced monocyte function in psoriasis, we determined monocyte chemotaxis and monocyte antibody-dependent cell-mediated cytotoxicity (ADCC) at week 0, 2, 4 and 8 in psoriatics being treated with benoxaprofen.
"
01/01/1985 - "
Enhanced monocyte activity is present in psoriasis, and benoxaprofen is a drug that inhibits several aspects of monocyte function.
"
01/01/1985 - "
Normalization of monocyte chemotaxis precedes clinical resolution of psoriasis treated with benoxaprofen.
"
5.
Arthritis (Polyarthritis)
08/12/1982 - "
Food and Drug Administration (FDA) internal documents released this month by a House subcommittee allege that Eli Lilly and Company, which recently suspended sales of the anti-arthritis drug benoxaprofen, has repeatedly failed to report adverse effects of drugs it was testing or marketing.
"
07/01/1982 - "
The effect of benoxaprofen was examined on adjuvant-induced arthritis in rats by radiographic assessment of bone damage.
"
01/01/1982 - "
The ability of benoxaprofen to suppress bone damage associated with adjuvant-induced arthritis in rats was studied radiographically over a 49-day period.
"
11/01/1982 - "
Benoxaprofen: a new arthritis medication that causes phototoxicity.
"
01/01/1980 - "
Benoxaprofen was also moderately active in inhibiting developing adjuvant-induced arthritis; however, it exhibited a potent response in established adjuvant arthritis, and it was the only compound tested which showed marked inhibition of the directional movement of mononuclear cells.
"
Related Drugs and Biologics
1.
Indomethacin (Indometacin)
2.
benoxaprofen
3.
Ibuprofen (Motrin)
4.
Lipoxygenase (Lipoxygenase-1)
5.
Lipoxygenase Inhibitors
6.
Analgesics (Analgesic Drugs)
7.
Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
8.
Arachidonic Acid (Vitamin F)
9.
5,8,11,14-Eicosatetraynoic Acid (5,8,11,14 Eicosatetraynoic Acid)
10.
Masoprocol (Actinex)
Related Therapies and Procedures
1.
Therapeutics
2.
Intra-Articular Injections
3.
Renal Dialysis (Hemodialysis)