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ciclopirox (Loprox)

synthetic antifungal agent

Also Known As:

Loprox; Penlac; 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone ethanolamine salt; Batrafen; Dafnegin-CSC; HOE 296; HOE-296; ciclopirox olamine; ciclopiroxolamine; cyclopirox; cyclopyroxolamine

Networked: 185 relevant articles (48 outcomes, 52 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Pyridines: 41
    - Pyridones: 10
      - ciclopirox: 185

Experts

1.	Gupta, Aditya K: 14 articles (12/2014 - 05/2002)
2.	Gupta, A K: 11 articles (09/2005 - 01/2000)
3.	Skinner, Alayne R: 5 articles (07/2005 - 01/2003)
4.	Cooper, Elizabeth A: 4 articles (03/2012 - 09/2003)
5.	Baran, R: 4 articles (07/2009 - 10/2000)
6.	Schaller, Martin: 3 articles (10/2015 - 06/2003)
7.	Jäckel, Andreas: 3 articles (10/2015 - 01/2005)
8.	Hanauske-Abel, Hartmut M: 3 articles (01/2014 - 08/2002)
9.	Aly, Raza: 3 articles (03/2005 - 09/2003)
10.	Borelli, Claudia: 2 articles (10/2015 - 11/2009)

Related Diseases

1.	Onychomycosis (Tinea Unguium) 03/01/2006 - "Congenital candidal onychomycoses: effective cure with ciclopirox olamine 8% nail lacquer." 10/01/2000 - "Data from the pivotal US trials have demonstrated that ciclopirox nail lacquer 8% topical solution is significantly more effective than placebo in the treatment of onychomycosis caused by Trichophyton rubrum, and of mild to moderate toe onychomycosis without lunula involvement. " 09/01/1991 - "This study indicates that 8% ciclopirox olamine nail liquor, with its satisfactory efficacy and lack of side effects, is a good remedy for onychomycosis." 08/01/2001 - "We report the case of a 75-year-old man with moderate-to-severe onychomycosis who was treated successfully with ciclopirox nail lacquer solution 8%, the first topical antifungal agent approved by the Food and Drug Administration for the treatment of this disease." 10/01/2000 - "Ciclopirox nail lacquer solution 8% has been shown to be effective in the treatment of dermatophyte onychomycosis of mild to moderate severity Other studies report the effectiveness of ciclopirox nail lacquer in onychomycosis caused by Candida sp and nondermatophyte molds. "
2.	Seborrheic Dermatitis 01/01/2003 - "In a placebo-controlled, double-blind clinical study, we demonstrated that antifungal ciclopiroxolamine (CIC) 1% cream was effective in mild to moderate facial seborrheic dermatitis. " 01/01/2006 - "Varying frequencies and concentrations of ciclopirox shampoo have been shown to be effective and safe in the treatment of seborrheic dermatitis of the scalp." 03/01/2005 - "Ciclopirox olamine is a synthetic hydroxypiridone derived, broad spectrum, antifungal agent which has been used effectively to treat seborrheic dermatitis. " 07/01/2004 - "Ciclopirox shampoo 1% is effective and safe in the treatment of seborrheic dermatitis of the scalp." 09/01/2003 - "Ciclopirox gel is effective and safe in the treatment of seborrheic dermatitis of the scalp."
3.	Infection 05/01/2007 - "Ciclopirox 8% nail lacquer was safe, with treatment-related adverse events limited to infection in one patient, which resolved in 15 days; the patient completed the study. " 07/01/2015 - "Ciclopirox olamine cream 1% is a safe and feasible treatment for superficial cutaneous mycotic infections, especially Candida spp. infection, in children aged between 3 months and 10 years." 09/01/2013 - "Ciclopirox olamine (CPO) is indicated in the treatment of vaginal fungal infections. " 03/01/2012 - "Topicals such as ciclopirox nail lacquer may also be effective (data originating from Scopulariopsis brevicaulis and Acremonium species infections), especially when combined with chemical or surgical avulsion of the nail. " 10/01/2008 - "Ciclopirox is a synthetic antimycotic agent available in a variety of formulations to treat superficial fungal infections. "
4.	Tinea Pedis (Athlete's Foot) 09/01/2003 - "Ciclopirox, a broad-spectrum hydroxypyridone antifungal, has proven efficacy against the organisms commonly implicated in tinea pedis; Trichophyton rubrum, T.mentagrophytes and Epidermophyton floccosum. " 09/01/2003 - "Ciclopirox gel 0.77% applied twice daily for 4 weeks is an effective treatment of moderate interdigital tinea pedis due to T. " 09/01/2003 - "Two multicenter, double-blind, clinical studies compared the efficacy and safety of ciclopirox gel with that of its vehicle base in subjects with moderate interdigital tinea pedis with or without plantar involvement. " 09/01/2003 - "Ciclopirox gel in the treatment of patients with interdigital tinea pedis." 05/01/1989 - "Ciclopirox olamine lotion 1% was found to be significantly more effective than its vehicle in the treatment of patients with common tinea pedis. "
5.	Dermatitis 01/01/2005 - "Ciclopirox was safe and effective in the treatment of diaper dermatitis due to C. " 01/01/2005 - "This open-label study investigated the safety and efficacy of ciclopirox topical suspension 0.77% in the treatment of diaper dermatitis due to Candida albicans (C. " 01/01/2005 - "A multicenter, open-label study to assess the safety and efficacy of ciclopirox topical suspension 0.77% in the treatment of diaper dermatitis due to Candida albicans." 05/01/2001 - "Randomized, placebo-controlled, double-blind study on clinical efficacy of ciclopiroxolamine 1% cream in facial seborrhoeic dermatitis." 01/01/2006 - "Treatment of head and neck dermatitis with ciclopiroxolamine cream--results of a double-blind, placebo-controlled study."

Related Drugs and Biologics

1.	amorolfine
2.	terbinafine (Lamisil)
3.	Ketoconazole (Nizoral)
4.	ciclopirox (Loprox)
5.	Clotrimazole (Lotrimin)
6.	zinc pyrithione (ZPT)
7.	Itraconazole (Sporanox)
8.	Salicylic Acid (2 Hydroxybenzoic Acid)
9.	Antifungal Agents
10.	Econazole

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Transplants (Transplant)
3.	Lasers (Laser)