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protoporphyrinogen (protoporphyrinogen IX)

Also Known As:

protoporphyrinogen IX; 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethenyl-5,10,15,20,22,24-hexahydro-3,8,13,17-tetramethyl-

Networked: 13 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Abe, Masato: 1 article (01/2020)
2.	Adachi, Kazuhide: 1 article (01/2020)
3.	Boockvar, John A: 1 article (01/2020)
4.	Hasegawa, Mitsuhiro: 1 article (01/2020)
5.	Hirose, Yuichi: 1 article (01/2020)
6.	Khatri, Deepak: 1 article (01/2020)
7.	Kuwahara, Kiyonori: 1 article (01/2020)
8.	Langer, David J: 1 article (01/2020)
9.	Mukherjee, Joydeep: 1 article (01/2020)
10.	Murayama, Kazuhiro: 1 article (01/2020)

Related Diseases

1.	Variegate Porphyria (Protoporphyrinogen Oxidase Deficiency) 01/01/2018 - "Variegate porphyria (VP) is an autosomal dominant inherited disease with incomplete penetrance due to decreased activity of the Protoporphyrinogen Oxydase (PPOX) gene; most VP mutations are family specific. " 01/01/1976 - "It is suggested that the enzymic process involved in the conversion of protoporphyrinogen to protoporphyrin may be deficient in variegate porphyria." 07/01/1981 - "In variegate porphyria protoporphyrinogen oxidase, which catalyzes the oxidation of protoporphyrinogen to protoporphyrin, appears to be defective. " 04/03/1980 - "We measured the activities of protoporphyrinogen oxidase, which catalyzes the oxidation of protoporphyrinogen to protoporphyrin, and heme synthase, which catalyzes the chelation of iron to protoporphyrins, in cultured skin fibroblasts from five normal controls and five patients with variegate porphyria. "
2.	Hereditary Coproporphyria (Coproporphyrinogen Oxidase Deficiency) 09/12/2003 - "Coproporphyrinogen-III oxidase (CPO) catalyses the conversion of coproporphyrinogen-III to protoporphyrinogen-IX in the haem biosynthetic pathway, and its deficient activity is associated with human hereditary coproporphyria. " 03/15/2008 - "During heme biosynthesis, coproporphyrinogen III oxidase catalyzes the conversion of two propionate substituents from the highly reactive substrate coproporphyrinogen III into vinyl substituents, yielding protoporphyrinogen IX. Although the crystal structure of this important enzyme has recently been reported, the reaction mechanism of this intriguing enzyme remains the subject of intense speculation, as impairment of this enzyme has been shown to be the molecular cause behind hereditary coproporphyria. "
3.	Glioma (Gliomas) 01/01/2020 - "Commentary: The Correlation of Fluorescence of Protoporphyrinogen IX and Status of Isocitrate Dehydrogenase in Gliomas." 01/01/2020 - "The Correlation of Fluorescence of Protoporphyrinogen IX and Status of Isocitrate Dehydrogenase in Gliomas." 01/01/2020 - "In Vitro assay revealed that mutant IDH indirectly reduced the amount of exogenous 5-ALA-derived protoporphyrinogen IX in glioma cells by increasing activity of ferrochelatase and heme oxygenase 1. Mutant IDH1/2-induced metabolite changes of exogenous 5-ALA were suggested to contribute to the lesser intraoperative fluorescence in gliomas with mutant IDH1/2 than in those without."
4.	Gallstones (Gallstone) 01/01/1991 - "The major haem precursor overproduced in VP is protoporphyrinogen and protoporphyrin was present in the gallstones available for analysis. "
5.	Inborn Genetic Diseases (Disease, Hereditary) 04/12/1994 - "Coproporphyrinogen oxidase (EC 1.3.3.3) catalyzes the sixth step in the heme biosynthetic pathway, the oxidation of coproporphyrinogen III to protoporphyrinogen IX. The activity of this enzyme is deficient in the disease hereditary coproporphyria. "

Related Drugs and Biologics

1.	Heme (Haem)
2.	protoporphyrin IX
3.	coproporphyrinogen III
4.	Protoporphyrinogen Oxidase (Protox)
5.	Oxidoreductases (Dehydrogenase)
6.	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))
7.	Enzymes
8.	Heme Oxygenase-1
9.	Protoporphyrins
10.	Proteins (Proteins, Gene)