HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

beta-glucuronidase inhibitor

glycoprotein with strong anionic charge; non-competitive type inhibitor

Networked: 14 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - beta-glucuronidase inhibitor: 14
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Glycoproteins: 24834
    - beta-glucuronidase inhibitor: 14

Experts

1.	Hagiwara, T: 1 article (10/2006)
2.	Kamataki, T: 1 article (10/2006)
3.	Kumazawa, E: 1 article (10/2006)
4.	Nagai, E: 1 article (10/2006)
5.	Onose, S: 1 article (10/2006)
6.	Takasuna, K: 1 article (10/2006)
7.	Watanabe, K: 1 article (10/2006)
8.	Yoshida, S: 1 article (10/2006)
9.	Gourley, Glenn R: 1 article (08/2005)
10.	Kosorok, Michael R: 1 article (08/2005)

Related Diseases

1.	Carcinogenesis 01/01/1982 - "In this study of the role of microfloral beta-glucuronidase in colonic carcinogenesis, the effect of beta-glucuronidase inhibitor was evaluated. " 06/01/1984 - "Inhibition of 7,12-dimethylbenzanthracene-induced rat mammary tumorigenesis by 2,5-di-O-acetyl-D-glucaro-1,4:6,3-dilactone, an in vivo beta-glucuronidase inhibitor." 01/01/1982 - "Effect of beta-glucuronidase inhibitor on azoxymethane-induced colonic carcinogenesis in rats." 10/01/1986 - "Dietary calcium D-glucarate, an in vivo beta-glucuronidase inhibitor, reduced the steady state level of both beta-glucuronidase and 17-ketosteroid excretion in the highly susceptible A/He and SENCAR strains to that of strains known to be resistant to chemical carcinogenesis. "
2.	Diarrhea 07/01/2004 - "To evaluate the ability of D-saccharic acid 1.4-lactone (SAL), a beta-glucuronidase inhibitor, to prevent irinotecan hydrochloride (CPT-11) from inducing mucosal damage as a cause of diarrhea in rats. " 05/01/2003 - "Kampo medicine Hangeshashin-to (TJ-14) which contains baicalin, a beta-glucuronidase inhibitor, alleviates diarrhea induced by irinotecan (CPT-11). " 10/01/2006 - "We have demonstrated from a rat model that intestinal beta-glucuronidase may play a key role in the development of CPT-11-induced delayed diarrhea by the deconjugation of the luminal SN-38 glucuronide, and the elimination of the intestinal microflora by antibiotics or dosing of TJ-14, a Kampo medicine that contains beta-glucuronidase inhibitor baicalin, exerted a protective effect. "
3.	Urinary Bladder Neoplasms (Bladder Cancer) 12/01/1970 - "[Preventive effect of beta-glucuronidase inhibitor (SLA) on recurrence of the bladder tumor]." 11/01/1970 - "[The effect of added dietary beta-glucuronidase inhibitor on the occurrence of 2-acetyl-aminofluorene induced bladder tumors in rats]." 11/01/1962 - "Effect of a Beta-glucuronidase inhibitor and methylcholanthrene on the induction of bladder tumors in rats."
4.	Experimental Melanoma 08/15/1986 - "Incubation of the solid-phase HS substrates with B16 melanoma cell extracts in the presence of D-saccharic acid 1,4-lactone (a potent exo-beta-glucuronidase inhibitor) resulted in the time- and dose-dependent release of [14C]HS fragments. "
5.	Jaundice (Icterus) 08/01/2005 - "Decreased jaundice in the W/C group, which lacked a beta-glucuronidase inhibitor, suggests a different mechanism."

Related Drugs and Biologics

1.	Glucuronidase
2.	Glucaric Acid
3.	Irinotecan (Camptosar)
4.	baicalin
5.	Phenobarbital (Luminal)
6.	Methylcholanthrene
7.	Cell Extracts
8.	Dietary Calcium
9.	Blood Group Antigens (Blood Groups)
10.	Azoxymethane

Related Therapies and Procedures

1.	Kampo Medicine (Kampo)