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helvolic acid

structure

Also Known As:

16-(acetyloxy)-3,7-dioxo29-nordammara-1,17(20, 24-trien-21-oic acid)

Networked: 6 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cholestanes
      - Sterols: 2245
        Fusidic Acid: 545
        helvolic acid: 6
      - Cholestenes
        Cholestadienes
        Cholestadienols
        Fusidic Acid: 545
        helvolic acid: 6
Lipids: 114793
- Membrane Lipids: 1591
  - Sterols: 2245
    - Fusidic Acid: 545
      - helvolic acid: 6

Experts

1.	Ameye, M: 1 article (11/2020)
2.	Audenaert, K: 1 article (11/2020)
3.	Demeestere, K: 1 article (11/2020)
4.	Höfte, M: 1 article (11/2020)
5.	Peeters, K J: 1 article (11/2020)
6.	Bayram, Ozgur: 1 article (12/2017)
7.	Brakhage, Axel A: 1 article (12/2017)
8.	Dolan, Stephen: 1 article (12/2017)
9.	Dos Reis, Thaila Fernanda: 1 article (12/2017)
10.	Doyle, Sean: 1 article (12/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "In the present study, the in vivo antitumor effect of helvolic acid was investigated in murine sarcoma S180 tumor-bearing mice. " 01/01/2017 - "Synergistic antitumor efficacy of antibacterial helvolic acid from Cordyceps taii and cyclophosphamide in a tumor mouse model." 01/01/2017 - "The antibacterial agent helvolic acid, which was isolated from the active antitumor fraction of Cordyceps taii, showed potent cytotoxicity against different human cancer cells. "
2.	Sarcoma (Soft Tissue Sarcoma) 01/01/2017 - "In the present study, the in vivo antitumor effect of helvolic acid was investigated in murine sarcoma S180 tumor-bearing mice. "
3.	Mycoses (Diseases, Fungus) 10/26/2022 - "Production of Helvolic Acid in Metarhizium Contributes to Fungal Infection of Insects by Bacteriostatic Inhibition of the Host Cuticular Microbiomes." 10/26/2022 - "In this study, we found that the potent antibiotic helvolic acid (HA) produced by the insect pathogen Metarhizium robertsii contributes to natural fungal infection of insect hosts. "
4.	Tuberculosis (Tuberculoses) 08/01/2017 - "Gliotoxin (3), 12,13-dihydroxy-fumitremorgin C (11) and helvolic acid (12) exhibited very strong anti-tuberculosis activity towards Mycobacterium tuberculosis with the prominent MIC50 values of <0.03, 2.41 and 0.894 μM, respectively, which was here reported for the first time. "
5.	Starvation 12/01/2017 - "Liquid chromatography-mass spectrometry under standard and iron starvation conditions confirmed that the ΔppzA mutant had reduced production of pyripyropene A, fumagillin, fumiquinazoline A, triacetyl-fusarinine C, and helvolic acid. "

Related Drugs and Biologics

1.	Cyclophosphamide (Cytoxan)
2.	Anti-Bacterial Agents (Antibiotics)
3.	Cerulenin
4.	Salicylic Acid (2 Hydroxybenzoic Acid)
5.	Plant Growth Regulators (Plant Hormones)
6.	Iron
7.	Indoleacetic Acids (Auxin)
8.	Gliotoxin
9.	Abscisic Acid
10.	fumiquinazoline A