2- crotonyloxymethyl- (4R,5R,6R)- 4,5,6- trihydroxycyclohex- 2-enone (COTC)

01/01/2014 - "The National Cancer Institute's Comparative Oncology Trials Consortium (http://ccr.cancer.gov/resources/cop/COTC.asp) is a cooperative effort that provides infrastructure and resources to support this effort. "
01/01/2014 - "A proof-of-concept study was conducted by the Comparative Oncology Trials Consortium (COTC) to determine if tumor collection, prospective molecular profiling, and PMed report generation within 1 week was feasible in dogs. "
07/01/2010 - "The National Cancer Institute-Comparative Oncology Trials Consortium (NCI-COTC) aims to inform the development path of novel drugs and biologicals for human cancer patients through their evaluation in dogs with neoplasia. "
01/01/2009 - "The first study of the COTC has demonstrated the utility and efficiency of the established infrastructure to inform the development of new cancer drugs within large animal naturally occurring cancer models. "
01/01/2009 - "The COTC is a novel infrastructure to integrate cancers that naturally develop in pet dogs into the development path of new human drugs. "

01/01/2018 - "Intragastric and intraperitoneal immunization of B.s-CotC-CsPmy spores in mice resulted in egg reduction rates of 48.3 and 51.2% after challenge infection, respectively. "
04/01/2023 - "This study indicated that oral administration of CotC-LMBV recombinant spores could stimulate an effective immune response and enhance fish immunity against LMBV infection. "

02/01/1998 - "During the study period, 15 patients visited the COTC 446 times for the treatment of acute migraine, 80 patients visited the UCC 233 times, and 182 patients visited the ETU 238 times. "
02/01/1998 - "For a 7-month period in 1995, all patient visits for acute migraine headache to the COTC, UCC, and ETU were reviewed. "
02/01/1998 - "We compared treatment of patients with episodic, severe, migraine-vascular headaches in three outpatient settings associated with a major medical center: the Charlton Outpatient Therapy Center (COTC), a dedicated transfusion and injection facility which provides treatment based on physician orders written in advance of the patient's visit; a walk-in Urgent Care Center (UCC); and a traditional hospital emergency trauma unit (ETU). "

01/01/2015 - "A rapid dose-escalation study of NHS-IL12 administered subcutaneously to dogs with melanoma was conducted through the Comparative Oncology Trials Consortium (COTC). "

01/01/2018 - "Liver fibrosis degree in B.s-CotC-CsPmy spores treated groups was also significantly reduced. "
12/19/2016 - "The degree of liver fibrosis was significantly reduced after oral immunization with B.s-CotC-CsCP spores. "