schizandrin

08/01/2020 - "Exploring the protective effects of schizandrol A in acute myocardial ischemia mice by comprehensive metabolomics profiling integrated with molecular mechanism studies."
01/01/1999 - "Methylenedioxy group and cyclooctadiene ring as structural determinants of schisandrin in protecting against myocardial ischemia-reperfusion injury in rats."
01/01/2018 - "On the basis of preliminary studies and references of relevant literature about Sheng-Mai-San for myocardial ischemia, we chose three representative components (ginsenoside Rb1 (G), ruscogenin (R) and schisandrin (S)) for the optimization design studies. "
01/10/2021 - "Recently, a new drug combination GRS comprising ginsenoside Rb1 (G-Rb1), ruscogenin (R-Rus) and schisandrin (S-SA) was screened based on ShengMai preparations, which exhibited a prominent cardioprotective effects against myocardial ischemia/reperfusion (MI/R) injury. "
03/14/2014 - "Pharmacokinetic and nitric oxide (NO) release pharmacodynamic drug-drug interactions of ginsenoside Rg1, ginsenoside Rb1 and schisandrin were studied after intravenous administration of each compound with the dose of 10 mg/kg and their mixture with the total dose of 10 mg/kg to isoproterenol (ISO)-induced myocardial ischemia rats. "

01/01/2022 - "The results indicated that schisandrin improved cognitive impairment and hippocampal cell loss in rats. "
02/06/2023 - "Researches showed that schisandrin can improve the cognitive impairment and memory of AD mice, but the specific mechanism has not been fully elucidated. "
08/05/2020 - "However, the mechanism by which schisandrin regulates the cognitive decline is still unclear. "
04/01/2018 - "In Morris Water Maze test; untreated APP/PS1 mice displayed significant cognitive impairment compared with normal mice; schisandrin administration ameliorated the cognitive impairment and significantly decreased Aβ deposition in the hippocampus. "
01/01/2022 - "Schisandrin alleviates the cognitive impairment in rats with Alzheimer's disease by altering the gut microbiota composition to modulate the levels of endogenous metabolites in the plasma, brain, and feces."

04/01/2021 - "Schizandrin ameliorates behavioral disorders in hepatic injury mice via regulation of oxidative stress and neuroinflammation."
04/01/2021 - ": The present data revealed that hyperammonemia produced due to liver injury-induced oxidative stress and neuroinflammation in the hippocampus and prefrontal cortex resulting in anxiety and depression were improved by schizandrin."
04/01/2021 - "Furthermore, schizandrin could dramatically inhibit the neuroinflammation in mice by reducing pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) through regulating NF-κB/NLRP3/Iba-1 signaling. "
08/05/2020 - "Schisandrin ameliorates cognitive deficits, endoplasmic reticulum stress and neuroinflammation in streptozotocin (STZ)-induced Alzheimer's disease rats."
08/05/2020 - "In conclusion, schisandrin ameliorated STZ-induced cognitive dysfunction, ER stress and neuroinflammation which may be associated with up-regulation of SIRT1. "

02/06/2023 - "Combined with UPLC-Triple-TOF/MS-based plasma lipidomics and molecular pharmacology reveals the mechanisms of schisandrin against Alzheimer's disease."
01/01/2022 - "Schisandrin is one of the main active compounds isolated from the fruit of Schisandrae chinensis Fructus, which is scientifically proven to have beneficial effects on Alzheimer's disease (AD) treatment at the cellular and whole organism level. "
01/01/2021 - "Schisandrin which is derived from Schisandra chinensis has shown multiple pharmacological effects on various diseases including Alzheimer's disease (AD). "
01/01/2021 - "In recent years, schisandrin (SCH) was proved to improve Alzheimer's Disease (AD). "
01/01/2019 - "The protective underlying mechanisms of Schisandrin on SH-SY5Y cell model of Alzheimer's disease."

09/29/2021 - "Schisandrin has been shown to be effective against different cancers because of its ability to inhibit/prevent cancer via modulation of different cell signaling pathways. "
09/29/2021 - "Regulation of cell signaling pathways by Schisandrin in different cancers: Opting for "Swiss Army Knife" instead of "Blunderbuss"."
04/10/2018 - "Synthesis and biological evaluation of Schizandrin derivatives as potential anti-cancer agents."
02/01/2010 - "However, the antiproliferative effect of schizandrin against human cancer cells has been poorly determined to date. "
10/05/2012 - "Schizandrin has various effects such as anti-asthmatic, anti-cancer and anti-inflammatory effects. "